Safety and feasibility of transcatheter renal sympathetic denervation using different types of catheter and various radiofrequency settings
Background: To evaluate in vivo the feasibility and safety of renal sympathetic denervation (RSD) with different catheters and various radiofrequency protocols. Methods and results: Twenty-two pigs were included. First 2 pigs were enrolled in a feasibility protocol using one catheter and power from...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-06-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906716300124 |
| _version_ | 1828330020263690240 |
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| author | Bruno Rustum Andrea Jacob Atié Steffen Desh Phillip Lurz Gerhard Hindricks |
| author_facet | Bruno Rustum Andrea Jacob Atié Steffen Desh Phillip Lurz Gerhard Hindricks |
| author_sort | Bruno Rustum Andrea |
| collection | DOAJ |
| description | Background: To evaluate in vivo the feasibility and safety of renal sympathetic denervation (RSD) with different catheters and various radiofrequency protocols.
Methods and results: Twenty-two pigs were included. First 2 pigs were enrolled in a feasibility protocol using one catheter and power from 5 W to 20 W. The next 10 pigs underwent RSD with three different catheters and four different RF-power settings of 5 W, 8 W, 10 W and 12 W in one minute per lesion (Protocol 1). The following 10 (Pigs 13 to 22) underwent RSD with five types of catheters (including the Symplicity® catheter), powers of 8 W and 10 W and two minutes RF-application (Protocol 2). Angiographic data were obtained at baseline, during and after RSD. At last, renal arteries were excised and analyzed macroscopically. The first pig developed severe renal stenoses with lesions of 15 to 20 W correlated with macroscopic alterations. The second feasibility pig did not develop renal stenosis with 5 and 8 W. In Protocol 1 from 60 RF-lesions, we observed 7 stenoses (≥30%). Three were severe (one of 80% with 10 W and two of 80% with 12 W). In Protocol 2 from 57 lesions we observed only 1 stenosis of 50% with 8 W with Symplicity® catheter. Severe stenosis was not observed.
Conclusion: In this study, renal sympathetic denervation showed safety using five types of catheters when applying RF-energy less than 10 W, within main stems of arteries larger than 3.0 mm diameter and a distance between lesions of at least 1 time catheter tip length. |
| first_indexed | 2024-04-13T20:34:42Z |
| format | Article |
| id | doaj.art-e1f1f0942477466f93a22b96cf376182 |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-04-13T20:34:42Z |
| publishDate | 2016-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-e1f1f0942477466f93a22b96cf3761822022-12-22T02:31:05ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672016-06-0111C354210.1016/j.ijcha.2016.03.008Safety and feasibility of transcatheter renal sympathetic denervation using different types of catheter and various radiofrequency settingsBruno Rustum Andrea0Jacob Atié1Steffen Desh2Phillip Lurz3Gerhard Hindricks4Electrophysiology Department, Heart Center Leipzig, Leipzig, Sachsen, GermanyElectrophysiology Department, Clementino Fraga Filho University Hospital — UFRJ, Rio de Janeiro, RJ, BrazilCardiology Department, Heart Center Leipzig, Leipzig, Sachsen, GermanyCardiology Department, Heart Center Leipzig, Leipzig, Sachsen, GermanyElectrophysiology Department, Heart Center Leipzig, Leipzig, Sachsen, GermanyBackground: To evaluate in vivo the feasibility and safety of renal sympathetic denervation (RSD) with different catheters and various radiofrequency protocols. Methods and results: Twenty-two pigs were included. First 2 pigs were enrolled in a feasibility protocol using one catheter and power from 5 W to 20 W. The next 10 pigs underwent RSD with three different catheters and four different RF-power settings of 5 W, 8 W, 10 W and 12 W in one minute per lesion (Protocol 1). The following 10 (Pigs 13 to 22) underwent RSD with five types of catheters (including the Symplicity® catheter), powers of 8 W and 10 W and two minutes RF-application (Protocol 2). Angiographic data were obtained at baseline, during and after RSD. At last, renal arteries were excised and analyzed macroscopically. The first pig developed severe renal stenoses with lesions of 15 to 20 W correlated with macroscopic alterations. The second feasibility pig did not develop renal stenosis with 5 and 8 W. In Protocol 1 from 60 RF-lesions, we observed 7 stenoses (≥30%). Three were severe (one of 80% with 10 W and two of 80% with 12 W). In Protocol 2 from 57 lesions we observed only 1 stenosis of 50% with 8 W with Symplicity® catheter. Severe stenosis was not observed. Conclusion: In this study, renal sympathetic denervation showed safety using five types of catheters when applying RF-energy less than 10 W, within main stems of arteries larger than 3.0 mm diameter and a distance between lesions of at least 1 time catheter tip length.http://www.sciencedirect.com/science/article/pii/S2352906716300124Radiofrequency renal sympathetic denervationVarious ablation cathetersRadiofrequency protocolsSafety of renal denervation |
| spellingShingle | Bruno Rustum Andrea Jacob Atié Steffen Desh Phillip Lurz Gerhard Hindricks Safety and feasibility of transcatheter renal sympathetic denervation using different types of catheter and various radiofrequency settings International Journal of Cardiology: Heart & Vasculature Radiofrequency renal sympathetic denervation Various ablation catheters Radiofrequency protocols Safety of renal denervation |
| title | Safety and feasibility of transcatheter renal sympathetic denervation using different types of catheter and various radiofrequency settings |
| title_full | Safety and feasibility of transcatheter renal sympathetic denervation using different types of catheter and various radiofrequency settings |
| title_fullStr | Safety and feasibility of transcatheter renal sympathetic denervation using different types of catheter and various radiofrequency settings |
| title_full_unstemmed | Safety and feasibility of transcatheter renal sympathetic denervation using different types of catheter and various radiofrequency settings |
| title_short | Safety and feasibility of transcatheter renal sympathetic denervation using different types of catheter and various radiofrequency settings |
| title_sort | safety and feasibility of transcatheter renal sympathetic denervation using different types of catheter and various radiofrequency settings |
| topic | Radiofrequency renal sympathetic denervation Various ablation catheters Radiofrequency protocols Safety of renal denervation |
| url | http://www.sciencedirect.com/science/article/pii/S2352906716300124 |
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