Elevated osteopontin and IFNy serum levels and increased neutrophil-to-lymphocyte ratio are associated with the severity of symptoms in schizophrenia
Introduction Inflammation and immune dysregulation could contribute to the pathogenesis of schizophrenia. Osteopontin (OPN) is a key cytokine-like molecule in cellular immune response and it can directly modulate the cytokine expression and survival of microglia. Furthermore, its mRNA expression is...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-06-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822003029/type/journal_article |
| _version_ | 1797616817990008832 |
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| author | M. Kovács T. Tényi R. Kugyelka L. Prenek R. Herold P. Balogh D. Simon |
| author_facet | M. Kovács T. Tényi R. Kugyelka L. Prenek R. Herold P. Balogh D. Simon |
| author_sort | M. Kovács |
| collection | DOAJ |
| description |
Introduction
Inflammation and immune dysregulation could contribute to the pathogenesis of schizophrenia. Osteopontin (OPN) is a key cytokine-like molecule in cellular immune response and it can directly modulate the cytokine expression and survival of microglia. Furthermore, its mRNA expression is elevated in first episode psychosis. Imbalance of T-helper subtypes could also represent a vulnerability factor for schizophrenia.
Objectives
The aim of this study was to evaluate the relevance of T-helper subtype associated cytokines, OPN and NLR in the assessment of the severity of schizophrenia.
Methods
22 patients with schizophrenia were assessed for the intensity of their symptoms by PANSS and CGI scores. Serum OPN, IFNy, IL-10 and IL-8 concentrations were measured by ELISA kits and NLR was calculated from blood count. Statistical evaluation was performed using Mann-Whitney U test, Student’s t test and Spearman correlation.
Results
We found significant correlation between the level of OPN and PANSS-total, PANSS-general scores. IFNy level and NLR showed significant correlation with PANSS-total, PANSS-positive, PANSS-general and CGI score. Antipsychotic therapy only had significant effects on NLR and OPN levels, both of which were significantly reduced after long-term antipsychotic treatment.
Conclusions
Our results indicate that elevated OPN and IFNy concentrations, and increased NLR are associated with severe symptoms in schizophrenia and suggest the importance of Th1 subtype in patients with high PANSS-positive and PANSS-general score. Antipsychotic treatment had significant effects on the level of OPN and NLR, but not on the level of IFNy. Overall our results strengthen the inflammation hypothesis of schizophrenia.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:45:42Z |
| format | Article |
| id | doaj.art-e1f2f3faa13e4962ae1aa916fc204664 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:45:42Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-e1f2f3faa13e4962ae1aa916fc2046642023-11-17T05:07:39ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S106S10610.1192/j.eurpsy.2022.302Elevated osteopontin and IFNy serum levels and increased neutrophil-to-lymphocyte ratio are associated with the severity of symptoms in schizophreniaM. Kovács0T. Tényi1R. Kugyelka2L. Prenek3R. Herold4P. Balogh5D. Simon6Medical Faculty, University of Pécs, Hungary, Department Of Psychiatry And Psychotherapy, Pécs, HungaryMedical Faculty, University of Pécs, Hungary, Department Of Psychiatry And Psychotherapy, Pécs, HungaryMedical Faculty, University of Pécs, Hungary, Department Of Immunology And Biotechnology, Pécs, HungaryMedical Faculty, University of Pécs, Hungary, Department Of Immunology And Biotechnology, Pécs, HungaryMedical Faculty, University of Pécs, Hungary, Department Of Psychiatry And Psychotherapy, Pécs, HungaryMedical Faculty, University of Pécs, Hungary, Department Of Immunology And Biotechnology, Pécs, HungaryMedical Faculty, University of Pécs, Hungary, Department Of Immunology And Biotechnology, Pécs, Hungary Introduction Inflammation and immune dysregulation could contribute to the pathogenesis of schizophrenia. Osteopontin (OPN) is a key cytokine-like molecule in cellular immune response and it can directly modulate the cytokine expression and survival of microglia. Furthermore, its mRNA expression is elevated in first episode psychosis. Imbalance of T-helper subtypes could also represent a vulnerability factor for schizophrenia. Objectives The aim of this study was to evaluate the relevance of T-helper subtype associated cytokines, OPN and NLR in the assessment of the severity of schizophrenia. Methods 22 patients with schizophrenia were assessed for the intensity of their symptoms by PANSS and CGI scores. Serum OPN, IFNy, IL-10 and IL-8 concentrations were measured by ELISA kits and NLR was calculated from blood count. Statistical evaluation was performed using Mann-Whitney U test, Student’s t test and Spearman correlation. Results We found significant correlation between the level of OPN and PANSS-total, PANSS-general scores. IFNy level and NLR showed significant correlation with PANSS-total, PANSS-positive, PANSS-general and CGI score. Antipsychotic therapy only had significant effects on NLR and OPN levels, both of which were significantly reduced after long-term antipsychotic treatment. Conclusions Our results indicate that elevated OPN and IFNy concentrations, and increased NLR are associated with severe symptoms in schizophrenia and suggest the importance of Th1 subtype in patients with high PANSS-positive and PANSS-general score. Antipsychotic treatment had significant effects on the level of OPN and NLR, but not on the level of IFNy. Overall our results strengthen the inflammation hypothesis of schizophrenia. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933822003029/type/journal_articleosteopontinCytokinesinflammationschizophrénia |
| spellingShingle | M. Kovács T. Tényi R. Kugyelka L. Prenek R. Herold P. Balogh D. Simon Elevated osteopontin and IFNy serum levels and increased neutrophil-to-lymphocyte ratio are associated with the severity of symptoms in schizophrenia European Psychiatry osteopontin Cytokines inflammation schizophrénia |
| title | Elevated osteopontin and IFNy serum levels and increased neutrophil-to-lymphocyte ratio are associated with the severity of symptoms in schizophrenia |
| title_full | Elevated osteopontin and IFNy serum levels and increased neutrophil-to-lymphocyte ratio are associated with the severity of symptoms in schizophrenia |
| title_fullStr | Elevated osteopontin and IFNy serum levels and increased neutrophil-to-lymphocyte ratio are associated with the severity of symptoms in schizophrenia |
| title_full_unstemmed | Elevated osteopontin and IFNy serum levels and increased neutrophil-to-lymphocyte ratio are associated with the severity of symptoms in schizophrenia |
| title_short | Elevated osteopontin and IFNy serum levels and increased neutrophil-to-lymphocyte ratio are associated with the severity of symptoms in schizophrenia |
| title_sort | elevated osteopontin and ifny serum levels and increased neutrophil to lymphocyte ratio are associated with the severity of symptoms in schizophrenia |
| topic | osteopontin Cytokines inflammation schizophrénia |
| url | https://www.cambridge.org/core/product/identifier/S0924933822003029/type/journal_article |
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