A retrospective analysis of postoperative hypokalemia in pituitary adenomas after transsphenoidal surgery
Background Pituitary adenoma is one of the most common intracranial neoplasms, and its primary treatment is endoscopic endonasal transsphenoidal tumorectomy. Postoperative hypokalemia in these patients is a common complication, and is associated with morbidity and mortality. This study aimed to anal...
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PeerJ Inc.
2017-05-01
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| Online Access: | https://peerj.com/articles/3337.pdf |
| _version_ | 1827607310378205184 |
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| author | Lili You Wenpeng Li Tang Chen Dongfang Tang Jinliang You Xianfeng Zhang |
| author_facet | Lili You Wenpeng Li Tang Chen Dongfang Tang Jinliang You Xianfeng Zhang |
| author_sort | Lili You |
| collection | DOAJ |
| description | Background Pituitary adenoma is one of the most common intracranial neoplasms, and its primary treatment is endoscopic endonasal transsphenoidal tumorectomy. Postoperative hypokalemia in these patients is a common complication, and is associated with morbidity and mortality. This study aimed to analyze the etiopathology of postoperative hypokalemia in pituitary adenomas after endoscopic transsphenoidal surgery. Methods and Materials This retrospective study included 181 pituitary adenomas confirmed by histopathology. Unconditional logistic regression analysis was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Repeated measures ANOVA was used to analyze change in serum potassium levels at different time points. Results Multiple Logistic regression analysis revealed that only ACTH-pituitary adenoma (OR = 4.92, 95% CI [1.18–20.48], P = 0.029) had a significant association with postoperative hypokalemia. Moreover, the overall mean serum potassium concentration was significantly lower in the ACTH versus the non-ACTH group (3.34 mmol/L vs. 3.79 mmol/L, P = 0.001). Postoperative hypokalemia was predominantly found in patients with ACTH-pituitary adenoma (P = 0.033). Conclusions ACTH-pituitary adenomas may be an independent factor related postoperative hypokalemia in patients despite conventional potassium supplementation in the immediate postoperative period. |
| first_indexed | 2024-03-09T06:52:39Z |
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| id | doaj.art-e1f39fba8a4646498a5294aee8a1c6ca |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:52:39Z |
| publishDate | 2017-05-01 |
| publisher | PeerJ Inc. |
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| spelling | doaj.art-e1f39fba8a4646498a5294aee8a1c6ca2023-12-03T10:22:37ZengPeerJ Inc.PeerJ2167-83592017-05-015e333710.7717/peerj.3337A retrospective analysis of postoperative hypokalemia in pituitary adenomas after transsphenoidal surgeryLili You0Wenpeng Li1Tang Chen2Dongfang Tang3Jinliang You4Xianfeng Zhang5Department of Clinical Epidemiology, First Hospital of Jilin University, Changchun, ChinaDepartment of Neurosurgery, First Hospital of Jilin University, Changchun, ChinaDepartment of Neurosurgery, First Hospital of Jilin University, Changchun, ChinaDepartment of Neurosurgery, First Hospital of Jilin University, Changchun, ChinaDepartment of Neurosurgery, First Hospital of Jilin University, Changchun, ChinaDepartment of Neurosurgery, First Hospital of Jilin University, Changchun, ChinaBackground Pituitary adenoma is one of the most common intracranial neoplasms, and its primary treatment is endoscopic endonasal transsphenoidal tumorectomy. Postoperative hypokalemia in these patients is a common complication, and is associated with morbidity and mortality. This study aimed to analyze the etiopathology of postoperative hypokalemia in pituitary adenomas after endoscopic transsphenoidal surgery. Methods and Materials This retrospective study included 181 pituitary adenomas confirmed by histopathology. Unconditional logistic regression analysis was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Repeated measures ANOVA was used to analyze change in serum potassium levels at different time points. Results Multiple Logistic regression analysis revealed that only ACTH-pituitary adenoma (OR = 4.92, 95% CI [1.18–20.48], P = 0.029) had a significant association with postoperative hypokalemia. Moreover, the overall mean serum potassium concentration was significantly lower in the ACTH versus the non-ACTH group (3.34 mmol/L vs. 3.79 mmol/L, P = 0.001). Postoperative hypokalemia was predominantly found in patients with ACTH-pituitary adenoma (P = 0.033). Conclusions ACTH-pituitary adenomas may be an independent factor related postoperative hypokalemia in patients despite conventional potassium supplementation in the immediate postoperative period.https://peerj.com/articles/3337.pdfPituitary adenomasPostoperative hypokalemiaACTH-pituitary adenomas |
| spellingShingle | Lili You Wenpeng Li Tang Chen Dongfang Tang Jinliang You Xianfeng Zhang A retrospective analysis of postoperative hypokalemia in pituitary adenomas after transsphenoidal surgery PeerJ Pituitary adenomas Postoperative hypokalemia ACTH-pituitary adenomas |
| title | A retrospective analysis of postoperative hypokalemia in pituitary adenomas after transsphenoidal surgery |
| title_full | A retrospective analysis of postoperative hypokalemia in pituitary adenomas after transsphenoidal surgery |
| title_fullStr | A retrospective analysis of postoperative hypokalemia in pituitary adenomas after transsphenoidal surgery |
| title_full_unstemmed | A retrospective analysis of postoperative hypokalemia in pituitary adenomas after transsphenoidal surgery |
| title_short | A retrospective analysis of postoperative hypokalemia in pituitary adenomas after transsphenoidal surgery |
| title_sort | retrospective analysis of postoperative hypokalemia in pituitary adenomas after transsphenoidal surgery |
| topic | Pituitary adenomas Postoperative hypokalemia ACTH-pituitary adenomas |
| url | https://peerj.com/articles/3337.pdf |
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