Behavioral Despair Is Blocked by the Flavonoid Chrysin (5,7-Dihydroxyflavone) in a Rat Model of Surgical Menopause
Women have a high susceptibility to the negative effects of stress. Hormonal changes experienced throughout their reproductive life partially contribute to a higher incidence of anxiety and depression symptoms, particularly, during natural or surgical menopause. In preclinical research, the flavonoi...
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MDPI AG
2023-01-01
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| Online Access: | https://www.mdpi.com/1420-3049/28/2/587 |
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| author | Luis Ángel Flores-Aguilar Jonathan Cueto-Escobedo Abraham Puga-Olguín Oscar Jerónimo Olmos-Vázquez Gilberto Uriel Rosas-Sánchez Blandina Bernal-Morales Juan Francisco Rodríguez-Landa |
| author_facet | Luis Ángel Flores-Aguilar Jonathan Cueto-Escobedo Abraham Puga-Olguín Oscar Jerónimo Olmos-Vázquez Gilberto Uriel Rosas-Sánchez Blandina Bernal-Morales Juan Francisco Rodríguez-Landa |
| author_sort | Luis Ángel Flores-Aguilar |
| collection | DOAJ |
| description | Women have a high susceptibility to the negative effects of stress. Hormonal changes experienced throughout their reproductive life partially contribute to a higher incidence of anxiety and depression symptoms, particularly, during natural or surgical menopause. In preclinical research, the flavonoid chrysin (5,7-dihydroxyflavone) exerts anxiolytic- and anti-despair-like effects; however, it is unknown whether chrysin exerts a protective effect against the behavioral changes produced by acute stress on locomotor activity and behavioral despair in rats at 12-weeks post-ovariectomy. Ovariectomized female Wistar rats were assigned to eight groups: vehicle group (10% DMSO), three groups with chrysin and three groups with the same dose of allopregnanolone (0.5, 1, and 2 mg/kg), and one group with diazepam (2 mg/kg). The treatments were administered for seven consecutive days and the effects were evaluated in the locomotor activity and swimming tests. Chrysin (2 mg/kg) increased the latency to first immobility and decreased the total immobility time in the swimming test as the reference drugs allopregnanolone and diazepam (2 mg/kg); while locomotor activity prevented the behavioral changes produced by swimming. In conclusion, chrysin exerts a protective effect against the behavioral changes induced by acute stress, similarly to the neurosteroid allopregnanolone and the benzodiazepine diazepam in rats subjected to a surgical menopause model. |
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| language | English |
| last_indexed | 2024-03-09T11:36:31Z |
| publishDate | 2023-01-01 |
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| series | Molecules |
| spelling | doaj.art-e1f3bc89f8694159adbfa880e5bf6c502023-11-30T23:41:55ZengMDPI AGMolecules1420-30492023-01-0128258710.3390/molecules28020587Behavioral Despair Is Blocked by the Flavonoid Chrysin (5,7-Dihydroxyflavone) in a Rat Model of Surgical MenopauseLuis Ángel Flores-Aguilar0Jonathan Cueto-Escobedo1Abraham Puga-Olguín2Oscar Jerónimo Olmos-Vázquez3Gilberto Uriel Rosas-Sánchez4Blandina Bernal-Morales5Juan Francisco Rodríguez-Landa6Programa de Doctorado en Neuroetología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa 91190, MexicoDepartamento de Investigación Clínica y Traslacional, Instituto de Ciencias de la Salud, Universidad Veracruzana, Xalapa 91190, MexicoUnidad de Salud Integrativa, Centro de EcoAlfabetización y Diálogo de Saberes, Universidad Veracruzana, Xalapa 91060, MexicoLaboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa 91190, MexicoLaboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa 91190, MexicoLaboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa 91190, MexicoLaboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa 91190, MexicoWomen have a high susceptibility to the negative effects of stress. Hormonal changes experienced throughout their reproductive life partially contribute to a higher incidence of anxiety and depression symptoms, particularly, during natural or surgical menopause. In preclinical research, the flavonoid chrysin (5,7-dihydroxyflavone) exerts anxiolytic- and anti-despair-like effects; however, it is unknown whether chrysin exerts a protective effect against the behavioral changes produced by acute stress on locomotor activity and behavioral despair in rats at 12-weeks post-ovariectomy. Ovariectomized female Wistar rats were assigned to eight groups: vehicle group (10% DMSO), three groups with chrysin and three groups with the same dose of allopregnanolone (0.5, 1, and 2 mg/kg), and one group with diazepam (2 mg/kg). The treatments were administered for seven consecutive days and the effects were evaluated in the locomotor activity and swimming tests. Chrysin (2 mg/kg) increased the latency to first immobility and decreased the total immobility time in the swimming test as the reference drugs allopregnanolone and diazepam (2 mg/kg); while locomotor activity prevented the behavioral changes produced by swimming. In conclusion, chrysin exerts a protective effect against the behavioral changes induced by acute stress, similarly to the neurosteroid allopregnanolone and the benzodiazepine diazepam in rats subjected to a surgical menopause model.https://www.mdpi.com/1420-3049/28/2/587anti-stressbenzodiazepinedespairflavonoidneurosteroidsurgical menopause |
| spellingShingle | Luis Ángel Flores-Aguilar Jonathan Cueto-Escobedo Abraham Puga-Olguín Oscar Jerónimo Olmos-Vázquez Gilberto Uriel Rosas-Sánchez Blandina Bernal-Morales Juan Francisco Rodríguez-Landa Behavioral Despair Is Blocked by the Flavonoid Chrysin (5,7-Dihydroxyflavone) in a Rat Model of Surgical Menopause Molecules anti-stress benzodiazepine despair flavonoid neurosteroid surgical menopause |
| title | Behavioral Despair Is Blocked by the Flavonoid Chrysin (5,7-Dihydroxyflavone) in a Rat Model of Surgical Menopause |
| title_full | Behavioral Despair Is Blocked by the Flavonoid Chrysin (5,7-Dihydroxyflavone) in a Rat Model of Surgical Menopause |
| title_fullStr | Behavioral Despair Is Blocked by the Flavonoid Chrysin (5,7-Dihydroxyflavone) in a Rat Model of Surgical Menopause |
| title_full_unstemmed | Behavioral Despair Is Blocked by the Flavonoid Chrysin (5,7-Dihydroxyflavone) in a Rat Model of Surgical Menopause |
| title_short | Behavioral Despair Is Blocked by the Flavonoid Chrysin (5,7-Dihydroxyflavone) in a Rat Model of Surgical Menopause |
| title_sort | behavioral despair is blocked by the flavonoid chrysin 5 7 dihydroxyflavone in a rat model of surgical menopause |
| topic | anti-stress benzodiazepine despair flavonoid neurosteroid surgical menopause |
| url | https://www.mdpi.com/1420-3049/28/2/587 |
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