Acute TMS/fMRI response explains offline TMS network effects – An interleaved TMS-fMRI study
Background: Transcranial magnetic stimulation (TMS) is an FDA-approved therapeutic option for treatment resistant depression. However, exact mechanisms-of-action are not fully understood and individual responses are variable. Moreover, although previously suggested, the exact network effects underly...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811922009545 |
| _version_ | 1811177309884907520 |
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| author | M. Tik M. Woletz A.-L. Schuler M. Vasileiadi R.F.H. Cash A. Zalesky C. Lamm C. Windischberger |
| author_facet | M. Tik M. Woletz A.-L. Schuler M. Vasileiadi R.F.H. Cash A. Zalesky C. Lamm C. Windischberger |
| author_sort | M. Tik |
| collection | DOAJ |
| description | Background: Transcranial magnetic stimulation (TMS) is an FDA-approved therapeutic option for treatment resistant depression. However, exact mechanisms-of-action are not fully understood and individual responses are variable. Moreover, although previously suggested, the exact network effects underlying TMS’ efficacy are poorly understood as of today. Although, it is supposed that DLPFC stimulation indirectly modulates the sgACC, recent evidence is sparse. Methods: Here, we used concurrent interleaved TMS/fMRI and state-of-the-science purpose-designed MRI head coils to delineate networks and downstream regions activated by DLPFC-TMS. Results: We show that regions of increased acute BOLD signal activation during TMS resemble a resting-state brain network previously shown to be modulated by offline TMS. There was a topographical overlap in wide spread cortical and sub-cortical areas within this specific RSN#17 derived from the 1000 functional connectomes project. Conclusion: These data imply a causal relation between DLPFC-TMS and activation of the ACC and a broader network that has been implicated in MDD. In the broader context of our recent work, these data imply a direct relation between initial changes in BOLD activity mediated by connectivity to the DLPFC target site, and later consolidation of connectivity between these regions. These insights advance our understanding of the mechanistic targets of DLPFC-TMS and may provide novel opportunities to characterize and optimize TMS therapy in other neurological and psychiatric disorders. |
| first_indexed | 2024-04-10T22:59:38Z |
| format | Article |
| id | doaj.art-e1f3e2b93e4d44008d3ae128e7daf48e |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-04-10T22:59:38Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-e1f3e2b93e4d44008d3ae128e7daf48e2023-01-14T04:26:17ZengElsevierNeuroImage1095-95722023-02-01267119833Acute TMS/fMRI response explains offline TMS network effects – An interleaved TMS-fMRI studyM. Tik0M. Woletz1A.-L. Schuler2M. Vasileiadi3R.F.H. Cash4A. Zalesky5C. Lamm6C. Windischberger7High-Field MR Center, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, AustriaHigh-Field MR Center, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, AustriaHigh-Field MR Center, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, AustriaHigh-Field MR Center, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, AustriaMelbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, Victoria, Australia; Department of Biomedical Engineering, University of Melbourne, Melbourne, Victoria, AustraliaMelbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, Victoria, Australia; Department of Biomedical Engineering, University of Melbourne, Melbourne, Victoria, AustraliaSocial Cognitive and Affective Neuroscience Unit, Department of Cognition, Emotion, and Methods in Psychology, Faculty of Psychology, University of Vienna, AustriaHigh-Field MR Center, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria; Corresponding author.Background: Transcranial magnetic stimulation (TMS) is an FDA-approved therapeutic option for treatment resistant depression. However, exact mechanisms-of-action are not fully understood and individual responses are variable. Moreover, although previously suggested, the exact network effects underlying TMS’ efficacy are poorly understood as of today. Although, it is supposed that DLPFC stimulation indirectly modulates the sgACC, recent evidence is sparse. Methods: Here, we used concurrent interleaved TMS/fMRI and state-of-the-science purpose-designed MRI head coils to delineate networks and downstream regions activated by DLPFC-TMS. Results: We show that regions of increased acute BOLD signal activation during TMS resemble a resting-state brain network previously shown to be modulated by offline TMS. There was a topographical overlap in wide spread cortical and sub-cortical areas within this specific RSN#17 derived from the 1000 functional connectomes project. Conclusion: These data imply a causal relation between DLPFC-TMS and activation of the ACC and a broader network that has been implicated in MDD. In the broader context of our recent work, these data imply a direct relation between initial changes in BOLD activity mediated by connectivity to the DLPFC target site, and later consolidation of connectivity between these regions. These insights advance our understanding of the mechanistic targets of DLPFC-TMS and may provide novel opportunities to characterize and optimize TMS therapy in other neurological and psychiatric disorders.http://www.sciencedirect.com/science/article/pii/S1053811922009545TMS/fMRIAcute TMS effectsACC1000 functional connectomes projectClinical application |
| spellingShingle | M. Tik M. Woletz A.-L. Schuler M. Vasileiadi R.F.H. Cash A. Zalesky C. Lamm C. Windischberger Acute TMS/fMRI response explains offline TMS network effects – An interleaved TMS-fMRI study NeuroImage TMS/fMRI Acute TMS effects ACC 1000 functional connectomes project Clinical application |
| title | Acute TMS/fMRI response explains offline TMS network effects – An interleaved TMS-fMRI study |
| title_full | Acute TMS/fMRI response explains offline TMS network effects – An interleaved TMS-fMRI study |
| title_fullStr | Acute TMS/fMRI response explains offline TMS network effects – An interleaved TMS-fMRI study |
| title_full_unstemmed | Acute TMS/fMRI response explains offline TMS network effects – An interleaved TMS-fMRI study |
| title_short | Acute TMS/fMRI response explains offline TMS network effects – An interleaved TMS-fMRI study |
| title_sort | acute tms fmri response explains offline tms network effects an interleaved tms fmri study |
| topic | TMS/fMRI Acute TMS effects ACC 1000 functional connectomes project Clinical application |
| url | http://www.sciencedirect.com/science/article/pii/S1053811922009545 |
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