Adult Stem Cell-Derived Extracellular Vesicles in Cancer Treatment: Opportunities and Challenges
Adult stem cells (SCs) participate in tissue repair and homeostasis regulation. The relative ease of SC handling and their therapeutic effect has made of these cell popular candidates for cellular therapy. However, several problems interfere with their clinical application in cancer treatment, like...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/5/1171 |
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| author | Vadims Parfejevs Krizia Sagini Arturs Buss Kristine Sobolevska Alicia Llorente Una Riekstina Arturs Abols |
| author_facet | Vadims Parfejevs Krizia Sagini Arturs Buss Kristine Sobolevska Alicia Llorente Una Riekstina Arturs Abols |
| author_sort | Vadims Parfejevs |
| collection | DOAJ |
| description | Adult stem cells (SCs) participate in tissue repair and homeostasis regulation. The relative ease of SC handling and their therapeutic effect has made of these cell popular candidates for cellular therapy. However, several problems interfere with their clinical application in cancer treatment, like safety issues, unpredictable pro-tumour effects, and tissue entrapment. Therefore cell-free therapies that exhibit SC properties are being investigated. It is now well known that adult SCs exhibit their therapeutic effect via paracrine mechanisms. In addition to secretory proteins, SCs also release extracellular vesicles (EV) that deliver their contents to the target cells. Cancer treatment is one of the most promising applications of SC-EVs. Moreover, SC-EVs could be modified to improve targeted drug delivery. The aim of the review is to summarise current knowledge of adult SC-EV application in cancer treatment and to emphasise future opportunities and challenges in cancer treatment. |
| first_indexed | 2024-03-10T19:57:55Z |
| format | Article |
| id | doaj.art-e1f469327439429a955925fc9c22f4d2 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T19:57:55Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-e1f469327439429a955925fc9c22f4d22023-11-19T23:49:51ZengMDPI AGCells2073-44092020-05-0195117110.3390/cells9051171Adult Stem Cell-Derived Extracellular Vesicles in Cancer Treatment: Opportunities and ChallengesVadims Parfejevs0Krizia Sagini1Arturs Buss2Kristine Sobolevska3Alicia Llorente4Una Riekstina5Arturs Abols6Faculty of Medicine, University of Latvia, House of Science, Jelgavas Str 3, LV-1004 Riga, LatviaDepartment of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, 0379 Oslo, NorwayLatvian Biomedical Research and Study Centre, Ratsupites Str 1, k-1, LV-1067 Riga, LatviaLatvian Biomedical Research and Study Centre, Ratsupites Str 1, k-1, LV-1067 Riga, LatviaDepartment of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, 0379 Oslo, NorwayFaculty of Medicine, University of Latvia, House of Science, Jelgavas Str 3, LV-1004 Riga, LatviaLatvian Biomedical Research and Study Centre, Ratsupites Str 1, k-1, LV-1067 Riga, LatviaAdult stem cells (SCs) participate in tissue repair and homeostasis regulation. The relative ease of SC handling and their therapeutic effect has made of these cell popular candidates for cellular therapy. However, several problems interfere with their clinical application in cancer treatment, like safety issues, unpredictable pro-tumour effects, and tissue entrapment. Therefore cell-free therapies that exhibit SC properties are being investigated. It is now well known that adult SCs exhibit their therapeutic effect via paracrine mechanisms. In addition to secretory proteins, SCs also release extracellular vesicles (EV) that deliver their contents to the target cells. Cancer treatment is one of the most promising applications of SC-EVs. Moreover, SC-EVs could be modified to improve targeted drug delivery. The aim of the review is to summarise current knowledge of adult SC-EV application in cancer treatment and to emphasise future opportunities and challenges in cancer treatment.https://www.mdpi.com/2073-4409/9/5/1171extracellular vesiclesmesenchymal stromal cellscancer treatment |
| spellingShingle | Vadims Parfejevs Krizia Sagini Arturs Buss Kristine Sobolevska Alicia Llorente Una Riekstina Arturs Abols Adult Stem Cell-Derived Extracellular Vesicles in Cancer Treatment: Opportunities and Challenges Cells extracellular vesicles mesenchymal stromal cells cancer treatment |
| title | Adult Stem Cell-Derived Extracellular Vesicles in Cancer Treatment: Opportunities and Challenges |
| title_full | Adult Stem Cell-Derived Extracellular Vesicles in Cancer Treatment: Opportunities and Challenges |
| title_fullStr | Adult Stem Cell-Derived Extracellular Vesicles in Cancer Treatment: Opportunities and Challenges |
| title_full_unstemmed | Adult Stem Cell-Derived Extracellular Vesicles in Cancer Treatment: Opportunities and Challenges |
| title_short | Adult Stem Cell-Derived Extracellular Vesicles in Cancer Treatment: Opportunities and Challenges |
| title_sort | adult stem cell derived extracellular vesicles in cancer treatment opportunities and challenges |
| topic | extracellular vesicles mesenchymal stromal cells cancer treatment |
| url | https://www.mdpi.com/2073-4409/9/5/1171 |
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