Umbilical cord-derived mesenchymal stromal cells immunomodulate and restore actin dynamics and phagocytosis of LPS-activated microglia via PI3K/Akt/Rho GTPase pathway

Umbilical cord-derived mesenchymal stromal cells immunomodulate and restore actin dynamics and phagocytosis of LPS-activated microglia via PI3K/Akt/Rho GTPase pathway

Abstract Microglia are the immune cells in the central nervous system surveying environment and reacting to various injuries. Activated microglia may cause impaired synaptic plasticity, therefore modulating and restoring them to neutral phenotype is crucial to counteract a pro-inflammatory, neurotox...

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Bibliographic Details
Main Authors: Takeo Mukai, Elena Di Martino, Shunichiro Tsuji, Klas Blomgren, Tokiko Nagamura-Inoue, Ulrika Ådén
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00436-w

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