Defibrotide improved the outcome of monocrotaline induced rat hepatic sinusoidal obstruction syndrome

Defibrotide improved the outcome of monocrotaline induced rat hepatic sinusoidal obstruction syndrome

Abstract Background and aim Pyrrolizidine alkaloids (PA) induced hepatic sinusoidal obstruction syndrome (HSOS) occurred worldwide and the mortality rate remained high because there were no specific therapies. Defibrotide was effective for HSOS following hematopoietic stem cell transplantation. But...

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Bibliographic Details
Main Authors: Zhenli Liu, Shan Liang, Xinhuan Wei, Xiaofei Du, Jing Zhang
Format: Article
Language:English
Published: BMC 2022-12-01
Series:BMC Gastroenterology
Subjects:
Hepatic sinusoidal obstruction syndrome
Monocrotaline
Defibrotide
Low molecular weight heparin
Online Access:https://doi.org/10.1186/s12876-022-02523-3

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