Clinical Determinants Predicting <i>Clostridioides difficile</i> Infection among Patients with Chronic Kidney Disease
The majority of recently published studies indicate a greater incidence rate and mortality due to Clostridioides difficile infection (CDI) in patients with chronic kidney disease (CKD). The aim of this study was to assess the clinical determinants predicting CDI among hospitalized patients with CKD...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/11/6/785 |
| _version_ | 1797490638996897792 |
|---|---|
| author | Łukasz Lis Andrzej Konieczny Michał Sroka Anna Ciszewska Kornelia Krakowska Tomasz Gołębiowski Zbigniew Hruby |
| author_facet | Łukasz Lis Andrzej Konieczny Michał Sroka Anna Ciszewska Kornelia Krakowska Tomasz Gołębiowski Zbigniew Hruby |
| author_sort | Łukasz Lis |
| collection | DOAJ |
| description | The majority of recently published studies indicate a greater incidence rate and mortality due to Clostridioides difficile infection (CDI) in patients with chronic kidney disease (CKD). The aim of this study was to assess the clinical determinants predicting CDI among hospitalized patients with CKD and refine methods of prevention. We evaluated the medical records of 279 patients treated at a nephrological department with symptoms suggesting CDI, of whom 93 tested positive for CDI. The survey showed that age, poor kidney function, high Padua prediction score (PPS) and patients’ classification of care at admission, treatment with antibiotics, and time of its duration were significantly higher or more frequent among patients who suffered CDI. Whereas BMI, Norton scale (ANSS) and serum albumin concentration were significantly lowered among CDI patients. In a multivariate analysis we proved the stage of CKD and length of antibiotics use increased the risk of CDI, whereas higher serum albumin concentration and ANSS have a protective impact. |
| first_indexed | 2024-03-10T00:35:52Z |
| format | Article |
| id | doaj.art-e1fad02d53de4ac08803de897dab107b |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T00:35:52Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-e1fad02d53de4ac08803de897dab107b2023-11-23T15:17:16ZengMDPI AGAntibiotics2079-63822022-06-0111678510.3390/antibiotics11060785Clinical Determinants Predicting <i>Clostridioides difficile</i> Infection among Patients with Chronic Kidney DiseaseŁukasz Lis0Andrzej Konieczny1Michał Sroka2Anna Ciszewska3Kornelia Krakowska4Tomasz Gołębiowski5Zbigniew Hruby6Research and Development Center, Department of Nephrology, Provincial Specialist Hospital, Kamienskiego 73a, 51-124 Wroclaw, PolandDepartment of Nephrology and Transplantation Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, PolandResearch and Development Center, Department of Nephrology, Provincial Specialist Hospital, Kamienskiego 73a, 51-124 Wroclaw, PolandDepartment of Intensive Care and Anesthesiology, Provincial Specialist Hospital, Kamienskiego 73a, 51-124 Wroclaw, PolandDepartment of Nephrology and Transplantation Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, PolandDepartment of Nephrology and Transplantation Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, PolandResearch and Development Center, Department of Nephrology, Provincial Specialist Hospital, Kamienskiego 73a, 51-124 Wroclaw, PolandThe majority of recently published studies indicate a greater incidence rate and mortality due to Clostridioides difficile infection (CDI) in patients with chronic kidney disease (CKD). The aim of this study was to assess the clinical determinants predicting CDI among hospitalized patients with CKD and refine methods of prevention. We evaluated the medical records of 279 patients treated at a nephrological department with symptoms suggesting CDI, of whom 93 tested positive for CDI. The survey showed that age, poor kidney function, high Padua prediction score (PPS) and patients’ classification of care at admission, treatment with antibiotics, and time of its duration were significantly higher or more frequent among patients who suffered CDI. Whereas BMI, Norton scale (ANSS) and serum albumin concentration were significantly lowered among CDI patients. In a multivariate analysis we proved the stage of CKD and length of antibiotics use increased the risk of CDI, whereas higher serum albumin concentration and ANSS have a protective impact.https://www.mdpi.com/2079-6382/11/6/785<i>Clostridioides difficile</i>chronic kidney diseasemalnutritionpseudomembranous enterocolitis |
| spellingShingle | Łukasz Lis Andrzej Konieczny Michał Sroka Anna Ciszewska Kornelia Krakowska Tomasz Gołębiowski Zbigniew Hruby Clinical Determinants Predicting <i>Clostridioides difficile</i> Infection among Patients with Chronic Kidney Disease Antibiotics <i>Clostridioides difficile</i> chronic kidney disease malnutrition pseudomembranous enterocolitis |
| title | Clinical Determinants Predicting <i>Clostridioides difficile</i> Infection among Patients with Chronic Kidney Disease |
| title_full | Clinical Determinants Predicting <i>Clostridioides difficile</i> Infection among Patients with Chronic Kidney Disease |
| title_fullStr | Clinical Determinants Predicting <i>Clostridioides difficile</i> Infection among Patients with Chronic Kidney Disease |
| title_full_unstemmed | Clinical Determinants Predicting <i>Clostridioides difficile</i> Infection among Patients with Chronic Kidney Disease |
| title_short | Clinical Determinants Predicting <i>Clostridioides difficile</i> Infection among Patients with Chronic Kidney Disease |
| title_sort | clinical determinants predicting i clostridioides difficile i infection among patients with chronic kidney disease |
| topic | <i>Clostridioides difficile</i> chronic kidney disease malnutrition pseudomembranous enterocolitis |
| url | https://www.mdpi.com/2079-6382/11/6/785 |
| work_keys_str_mv | AT łukaszlis clinicaldeterminantspredictingiclostridioidesdifficileiinfectionamongpatientswithchronickidneydisease AT andrzejkonieczny clinicaldeterminantspredictingiclostridioidesdifficileiinfectionamongpatientswithchronickidneydisease AT michałsroka clinicaldeterminantspredictingiclostridioidesdifficileiinfectionamongpatientswithchronickidneydisease AT annaciszewska clinicaldeterminantspredictingiclostridioidesdifficileiinfectionamongpatientswithchronickidneydisease AT korneliakrakowska clinicaldeterminantspredictingiclostridioidesdifficileiinfectionamongpatientswithchronickidneydisease AT tomaszgołebiowski clinicaldeterminantspredictingiclostridioidesdifficileiinfectionamongpatientswithchronickidneydisease AT zbigniewhruby clinicaldeterminantspredictingiclostridioidesdifficileiinfectionamongpatientswithchronickidneydisease |