Synergic effect of natural deep eutectic solvent and high-intensity ultrasound on obtaining a ready-to-use genipin extract: Crosslinking and anti-neurodegenerative properties
In this paper, genipin, an important natural crosslinker and anti-neurodegenerative compound, was extracted from unripe Genipa americana L., combining high-intensity ultrasound (HIUS) and natural deep eutectic solvents (NADESs). The extraction process conditions were evaluated step-by-step to reach...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Food Chemistry: X |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590157522002875 |
| _version_ | 1811192847029764096 |
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| author | Maria Isabel Landim Neves Bárbara Socas-Rodríguez Alberto Valdés Eric Keven Silva Alejandro Cifuentes Maria Angela A. Meireles Elena Ibáñez |
| author_facet | Maria Isabel Landim Neves Bárbara Socas-Rodríguez Alberto Valdés Eric Keven Silva Alejandro Cifuentes Maria Angela A. Meireles Elena Ibáñez |
| author_sort | Maria Isabel Landim Neves |
| collection | DOAJ |
| description | In this paper, genipin, an important natural crosslinker and anti-neurodegenerative compound, was extracted from unripe Genipa americana L., combining high-intensity ultrasound (HIUS) and natural deep eutectic solvents (NADESs). The extraction process conditions were evaluated step-by-step to reach the best genipin recovery. The obtained ready-to-use genipin-NADES extract was examined regarding its crosslinking properties and anti-neurodegenerative capacity. For the condictions tested, the highest genipin recovery was obtained using 40 % water and 60 % betaine:lactic acid NADES in molar ratio 1:3 (n/n) as the solvent, a solvent:feed ratio of 19 (w/w), and HIUS acoustic power of 14 ± 1 W. The HIUS-assisted extraction using NADES as solvent showed to be a promising and efficient green extraction technique to obtain genipin. The ready-to-use genipin-NADES extract presented crosslinking capacity and anticholinergic activity. These results indicate that genipin-NADES extract can be directly applied in hydrogels for drug delivery, films, tissue engineering, and others. Moreover, it can be used in food, supplements, and medicine to enhance their neuroprotective effect. |
| first_indexed | 2024-04-11T23:58:56Z |
| format | Article |
| id | doaj.art-e200356f80164cf2bba11abeefe20449 |
| institution | Directory Open Access Journal |
| issn | 2590-1575 |
| language | English |
| last_indexed | 2024-04-11T23:58:56Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Food Chemistry: X |
| spelling | doaj.art-e200356f80164cf2bba11abeefe204492022-12-22T03:56:18ZengElsevierFood Chemistry: X2590-15752022-12-0116100489Synergic effect of natural deep eutectic solvent and high-intensity ultrasound on obtaining a ready-to-use genipin extract: Crosslinking and anti-neurodegenerative propertiesMaria Isabel Landim Neves0Bárbara Socas-Rodríguez1Alberto Valdés2Eric Keven Silva3Alejandro Cifuentes4Maria Angela A. Meireles5Elena Ibáñez6Foodomics Laboratory, Department of Bioactivity and Food Analysis, CIAL, CSIC-UAM, Nicolas Cabrera 9, 28049 Madrid, Spain; School of Food Engineering, University of Campinas, Rua Monteiro Lobato, 80, Campinas-SP, CEP 13083-862, BrazilFoodomics Laboratory, Department of Bioactivity and Food Analysis, CIAL, CSIC-UAM, Nicolas Cabrera 9, 28049 Madrid, SpainFoodomics Laboratory, Department of Bioactivity and Food Analysis, CIAL, CSIC-UAM, Nicolas Cabrera 9, 28049 Madrid, SpainSchool of Food Engineering, University of Campinas, Rua Monteiro Lobato, 80, Campinas-SP, CEP 13083-862, BrazilFoodomics Laboratory, Department of Bioactivity and Food Analysis, CIAL, CSIC-UAM, Nicolas Cabrera 9, 28049 Madrid, SpainSchool of Food Engineering, University of Campinas, Rua Monteiro Lobato, 80, Campinas-SP, CEP 13083-862, BrazilFoodomics Laboratory, Department of Bioactivity and Food Analysis, CIAL, CSIC-UAM, Nicolas Cabrera 9, 28049 Madrid, Spain; Corresponding author.In this paper, genipin, an important natural crosslinker and anti-neurodegenerative compound, was extracted from unripe Genipa americana L., combining high-intensity ultrasound (HIUS) and natural deep eutectic solvents (NADESs). The extraction process conditions were evaluated step-by-step to reach the best genipin recovery. The obtained ready-to-use genipin-NADES extract was examined regarding its crosslinking properties and anti-neurodegenerative capacity. For the condictions tested, the highest genipin recovery was obtained using 40 % water and 60 % betaine:lactic acid NADES in molar ratio 1:3 (n/n) as the solvent, a solvent:feed ratio of 19 (w/w), and HIUS acoustic power of 14 ± 1 W. The HIUS-assisted extraction using NADES as solvent showed to be a promising and efficient green extraction technique to obtain genipin. The ready-to-use genipin-NADES extract presented crosslinking capacity and anticholinergic activity. These results indicate that genipin-NADES extract can be directly applied in hydrogels for drug delivery, films, tissue engineering, and others. Moreover, it can be used in food, supplements, and medicine to enhance their neuroprotective effect.http://www.sciencedirect.com/science/article/pii/S2590157522002875Genipa americana LGreen solventAlzheimer’s diseaseSonicationBetaineLactic acid |
| spellingShingle | Maria Isabel Landim Neves Bárbara Socas-Rodríguez Alberto Valdés Eric Keven Silva Alejandro Cifuentes Maria Angela A. Meireles Elena Ibáñez Synergic effect of natural deep eutectic solvent and high-intensity ultrasound on obtaining a ready-to-use genipin extract: Crosslinking and anti-neurodegenerative properties Food Chemistry: X Genipa americana L Green solvent Alzheimer’s disease Sonication Betaine Lactic acid |
| title | Synergic effect of natural deep eutectic solvent and high-intensity ultrasound on obtaining a ready-to-use genipin extract: Crosslinking and anti-neurodegenerative properties |
| title_full | Synergic effect of natural deep eutectic solvent and high-intensity ultrasound on obtaining a ready-to-use genipin extract: Crosslinking and anti-neurodegenerative properties |
| title_fullStr | Synergic effect of natural deep eutectic solvent and high-intensity ultrasound on obtaining a ready-to-use genipin extract: Crosslinking and anti-neurodegenerative properties |
| title_full_unstemmed | Synergic effect of natural deep eutectic solvent and high-intensity ultrasound on obtaining a ready-to-use genipin extract: Crosslinking and anti-neurodegenerative properties |
| title_short | Synergic effect of natural deep eutectic solvent and high-intensity ultrasound on obtaining a ready-to-use genipin extract: Crosslinking and anti-neurodegenerative properties |
| title_sort | synergic effect of natural deep eutectic solvent and high intensity ultrasound on obtaining a ready to use genipin extract crosslinking and anti neurodegenerative properties |
| topic | Genipa americana L Green solvent Alzheimer’s disease Sonication Betaine Lactic acid |
| url | http://www.sciencedirect.com/science/article/pii/S2590157522002875 |
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