MicroRNA-9 Inhibits NLRP3 Inflammasome Activation in Human Atherosclerosis Inflammation Cell Models through the JAK1/STAT Signaling Pathway

MicroRNA-9 Inhibits NLRP3 Inflammasome Activation in Human Atherosclerosis Inflammation Cell Models through the JAK1/STAT Signaling Pathway

Background/Aims: MicroRNA-9 (miR-9) is involved in inflammatory reaction in atherosclerosis; however, its function and regulatory mechanisms remain unclear. We aimed to uncover the exact roles of miR-9 and downstream signaling pathways using in vitro human atherosclerosis models. Methods: We used ox...

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Bibliographic Details
Main Authors: Yue Wang, Zhihua Han, Yuqi Fan, Junfeng Zhang, Kan Chen, Lin Gao, Huasu Zeng, Jiatian Cao, Changqian Wang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
NLRP3 inflammasome
miR-9
JAK1
STAT1
Atherosclerosis
Online Access:http://www.karger.com/Article/FullText/470822

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