Neural activity of the auditory cortex predicts speech recognition of patients with asymmetric hearing loss after cochlear implantation
Abstract Patients with asymmetric hearing loss show an asymmetry of glucose metabolism of the primary auditory cortex (PAC). We investigated whether this asymmetry could serve as an objective predictor for speech recognition with CI. Nine patients underwent 18FDG PET prior to CI surgery. Average nor...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-12139-y |
| _version_ | 1811341131801165824 |
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| author | Iva Speck Susan Arndt Johannes Thurow Alexander Rau Antje Aschendorff Philipp T. Meyer Lars Frings Ganna Blazhenets |
| author_facet | Iva Speck Susan Arndt Johannes Thurow Alexander Rau Antje Aschendorff Philipp T. Meyer Lars Frings Ganna Blazhenets |
| author_sort | Iva Speck |
| collection | DOAJ |
| description | Abstract Patients with asymmetric hearing loss show an asymmetry of glucose metabolism of the primary auditory cortex (PAC). We investigated whether this asymmetry could serve as an objective predictor for speech recognition with CI. Nine patients underwent 18FDG PET prior to CI surgery. Average normalized 18FDG uptake of 25% of voxels with highest uptake was calculated for the PAC employing a probabilistic atlas and cerebellar cortex as reference. Differences in glucose metabolism of the PAC were assessed by an asymmetry index (AI-PAC). We tested the correlation between outcome of CI surgery (6 months post implantation), AI-PAC and clinical predictors. Pre-operative AI-PAC showed a positive correlation with speech recognition with CI (significant for sentences and numbers; trend for monosyllabic words). With a pre-operative AI-PAC ≥ 4.2%, patients reached good CI outcome in sentence recognition of 59–90% and number recognition of 90–100% and less favorable CI outcome in monosyllabic word recognition of 25–45%. Age at symptom onset was significantly associated with all measures of speech recognition, while deafness duration was only associated with sentence recognition. AI-PAC allows for a reliable and quantitative pre-operative prediction of early improvement in speech recognition after CI. 18FDG PET may be a valuable addition to the objective pre-operative assessment of CI candidates. Further studies in larger cohorts and with longer follow-up times are needed. |
| first_indexed | 2024-04-13T18:52:12Z |
| format | Article |
| id | doaj.art-e201b0427c254edc871a42dae7d1ef44 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T18:52:12Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e201b0427c254edc871a42dae7d1ef442022-12-22T02:34:23ZengNature PortfolioScientific Reports2045-23222022-05-011211810.1038/s41598-022-12139-yNeural activity of the auditory cortex predicts speech recognition of patients with asymmetric hearing loss after cochlear implantationIva Speck0Susan Arndt1Johannes Thurow2Alexander Rau3Antje Aschendorff4Philipp T. Meyer5Lars Frings6Ganna Blazhenets7Department of Otorhinolaryngology - Head and Neck Surgery, Medical Center, Faculty of Medicine, University of FreiburgDepartment of Otorhinolaryngology - Head and Neck Surgery, Medical Center, Faculty of Medicine, University of FreiburgDepartment of Nuclear Medicine, Medical Center, Faculty of Medicine, University of FreiburgDepartment of Neuroradiology, Medical Center, Faculty of Medicine, University of FreiburgDepartment of Otorhinolaryngology - Head and Neck Surgery, Medical Center, Faculty of Medicine, University of FreiburgDepartment of Nuclear Medicine, Medical Center, Faculty of Medicine, University of FreiburgDepartment of Nuclear Medicine, Medical Center, Faculty of Medicine, University of FreiburgDepartment of Nuclear Medicine, Medical Center, Faculty of Medicine, University of FreiburgAbstract Patients with asymmetric hearing loss show an asymmetry of glucose metabolism of the primary auditory cortex (PAC). We investigated whether this asymmetry could serve as an objective predictor for speech recognition with CI. Nine patients underwent 18FDG PET prior to CI surgery. Average normalized 18FDG uptake of 25% of voxels with highest uptake was calculated for the PAC employing a probabilistic atlas and cerebellar cortex as reference. Differences in glucose metabolism of the PAC were assessed by an asymmetry index (AI-PAC). We tested the correlation between outcome of CI surgery (6 months post implantation), AI-PAC and clinical predictors. Pre-operative AI-PAC showed a positive correlation with speech recognition with CI (significant for sentences and numbers; trend for monosyllabic words). With a pre-operative AI-PAC ≥ 4.2%, patients reached good CI outcome in sentence recognition of 59–90% and number recognition of 90–100% and less favorable CI outcome in monosyllabic word recognition of 25–45%. Age at symptom onset was significantly associated with all measures of speech recognition, while deafness duration was only associated with sentence recognition. AI-PAC allows for a reliable and quantitative pre-operative prediction of early improvement in speech recognition after CI. 18FDG PET may be a valuable addition to the objective pre-operative assessment of CI candidates. Further studies in larger cohorts and with longer follow-up times are needed.https://doi.org/10.1038/s41598-022-12139-y |
| spellingShingle | Iva Speck Susan Arndt Johannes Thurow Alexander Rau Antje Aschendorff Philipp T. Meyer Lars Frings Ganna Blazhenets Neural activity of the auditory cortex predicts speech recognition of patients with asymmetric hearing loss after cochlear implantation Scientific Reports |
| title | Neural activity of the auditory cortex predicts speech recognition of patients with asymmetric hearing loss after cochlear implantation |
| title_full | Neural activity of the auditory cortex predicts speech recognition of patients with asymmetric hearing loss after cochlear implantation |
| title_fullStr | Neural activity of the auditory cortex predicts speech recognition of patients with asymmetric hearing loss after cochlear implantation |
| title_full_unstemmed | Neural activity of the auditory cortex predicts speech recognition of patients with asymmetric hearing loss after cochlear implantation |
| title_short | Neural activity of the auditory cortex predicts speech recognition of patients with asymmetric hearing loss after cochlear implantation |
| title_sort | neural activity of the auditory cortex predicts speech recognition of patients with asymmetric hearing loss after cochlear implantation |
| url | https://doi.org/10.1038/s41598-022-12139-y |
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