Trends in the multiple prescriptions of hypnotic drugs in a university outpatient in Japan
Abstract Aims In Japan, the daily dosage of hypnotic drugs for insomnia treatment is increasing year by year, and over‐dependence on treatment with hypnotic drugs is a major problem. This study aimed to examine the factors related to the elimination of prescriptions of three or more hypnotic drugs w...
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| Format: | Article |
| Language: | English |
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Wiley
2024-03-01
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| Series: | Neuropsychopharmacology Reports |
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| Online Access: | https://doi.org/10.1002/npr2.12386 |
| _version_ | 1827319280446734336 |
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| author | Takao Kato Nozomu Kotorii Motohiro Ozone Kenta Murotani Hayato Ohshima Hiroyuki Mori Kenjirou Wasano Hiroshi Hiejima Mitsunari Habukawa Naohisa Uchimura |
| author_facet | Takao Kato Nozomu Kotorii Motohiro Ozone Kenta Murotani Hayato Ohshima Hiroyuki Mori Kenjirou Wasano Hiroshi Hiejima Mitsunari Habukawa Naohisa Uchimura |
| author_sort | Takao Kato |
| collection | DOAJ |
| description | Abstract Aims In Japan, the daily dosage of hypnotic drugs for insomnia treatment is increasing year by year, and over‐dependence on treatment with hypnotic drugs is a major problem. This study aimed to examine the factors related to the elimination of prescriptions of three or more hypnotic drugs within 1 year in our clinic. Methods We conducted two surveys. Survey ① assessed the frequency of prescriptions of three or more hypnotic drugs by retrospectively reviewing the medical records of all patients who visited general and psychiatric outpatient clinics from January 2013 to March 2019. Survey ② assessed changes in prescriptions of hypnotic and psychotropic drugs within the subsequent year by retrospectively reviewing the medical records of all patients prescribed three or more hypnotic drugs who visited neuropsychiatric outpatient clinics multiple times between April 2013 and March 2019. Results The frequency of prescribing three or more hypnotic drugs was six to nine times higher in psychiatry than in other departments. Flunitrazepam and brotizolam were the most common drugs prescribed and had the second lowest discontinuation rate after zolpidem. Conversely, eszopiclone, zopiclone, and suvorexant had the highest discontinuation rates. The success factors for drug reduction were age (odds ratio [OR]: 0.97, p < 0.0037), trazodone addition (OR: 12.86, p < 0.0194) and number of years of psychiatric experience. Conclusions The characteristics and success factors in relation to drug reduction in patients with multiple prescriptions of hypnotic drugs identified in this study may contribute to solving the problem of multiple prescriptions of hypnotic drugs. |
| first_indexed | 2024-04-25T00:17:10Z |
| format | Article |
| id | doaj.art-e2035cb1a7274e358101b57075df11a2 |
| institution | Directory Open Access Journal |
| issn | 2574-173X |
| language | English |
| last_indexed | 2024-04-25T00:17:10Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neuropsychopharmacology Reports |
| spelling | doaj.art-e2035cb1a7274e358101b57075df11a22024-03-13T03:12:13ZengWileyNeuropsychopharmacology Reports2574-173X2024-03-01441808910.1002/npr2.12386Trends in the multiple prescriptions of hypnotic drugs in a university outpatient in JapanTakao Kato0Nozomu Kotorii1Motohiro Ozone2Kenta Murotani3Hayato Ohshima4Hiroyuki Mori5Kenjirou Wasano6Hiroshi Hiejima7Mitsunari Habukawa8Naohisa Uchimura9Department of Neuropsychiatry Kurume University School of Medicine Fukuoka JapanDepartment of Neuropsychiatry Kurume University School of Medicine Fukuoka JapanDepartment of Neuropsychiatry Kurume University School of Medicine Fukuoka JapanBiostatistics Center Kurume University Fukuoka JapanDepartment of Neuropsychiatry Kurume University School of Medicine Fukuoka JapanDepartment of Neuropsychiatry Kurume University School of Medicine Fukuoka JapanDepartment of Neuropsychiatry Kurume University School of Medicine Fukuoka JapanDepartment of Neuropsychiatry Kurume University School of Medicine Fukuoka JapanDepartment of Neuropsychiatry Kurume University School of Medicine Fukuoka JapanDepartment of Neuropsychiatry Kurume University School of Medicine Fukuoka JapanAbstract Aims In Japan, the daily dosage of hypnotic drugs for insomnia treatment is increasing year by year, and over‐dependence on treatment with hypnotic drugs is a major problem. This study aimed to examine the factors related to the elimination of prescriptions of three or more hypnotic drugs within 1 year in our clinic. Methods We conducted two surveys. Survey ① assessed the frequency of prescriptions of three or more hypnotic drugs by retrospectively reviewing the medical records of all patients who visited general and psychiatric outpatient clinics from January 2013 to March 2019. Survey ② assessed changes in prescriptions of hypnotic and psychotropic drugs within the subsequent year by retrospectively reviewing the medical records of all patients prescribed three or more hypnotic drugs who visited neuropsychiatric outpatient clinics multiple times between April 2013 and March 2019. Results The frequency of prescribing three or more hypnotic drugs was six to nine times higher in psychiatry than in other departments. Flunitrazepam and brotizolam were the most common drugs prescribed and had the second lowest discontinuation rate after zolpidem. Conversely, eszopiclone, zopiclone, and suvorexant had the highest discontinuation rates. The success factors for drug reduction were age (odds ratio [OR]: 0.97, p < 0.0037), trazodone addition (OR: 12.86, p < 0.0194) and number of years of psychiatric experience. Conclusions The characteristics and success factors in relation to drug reduction in patients with multiple prescriptions of hypnotic drugs identified in this study may contribute to solving the problem of multiple prescriptions of hypnotic drugs.https://doi.org/10.1002/npr2.12386antidepressantsantipsychoticsanxiolyticshypnoticsinsomniapolypharmacy |
| spellingShingle | Takao Kato Nozomu Kotorii Motohiro Ozone Kenta Murotani Hayato Ohshima Hiroyuki Mori Kenjirou Wasano Hiroshi Hiejima Mitsunari Habukawa Naohisa Uchimura Trends in the multiple prescriptions of hypnotic drugs in a university outpatient in Japan Neuropsychopharmacology Reports antidepressants antipsychotics anxiolytics hypnotics insomnia polypharmacy |
| title | Trends in the multiple prescriptions of hypnotic drugs in a university outpatient in Japan |
| title_full | Trends in the multiple prescriptions of hypnotic drugs in a university outpatient in Japan |
| title_fullStr | Trends in the multiple prescriptions of hypnotic drugs in a university outpatient in Japan |
| title_full_unstemmed | Trends in the multiple prescriptions of hypnotic drugs in a university outpatient in Japan |
| title_short | Trends in the multiple prescriptions of hypnotic drugs in a university outpatient in Japan |
| title_sort | trends in the multiple prescriptions of hypnotic drugs in a university outpatient in japan |
| topic | antidepressants antipsychotics anxiolytics hypnotics insomnia polypharmacy |
| url | https://doi.org/10.1002/npr2.12386 |
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