Differential roles of prostaglandin E-type receptors in activation of hypoxia-inducible factor 1 by prostaglandin E1 in vascular-derived cells under non-hypoxic conditions

Differential roles of prostaglandin E-type receptors in activation of hypoxia-inducible factor 1 by prostaglandin E1 in vascular-derived cells under non-hypoxic conditions

Prostaglandin E1 (PGE1), known pharmaceutically as alprostadil, has vasodilatory properties and is used widely in various clinical settings. In addition to acute vasodilatory properties, PGE1 may exert beneficial effects by altering protein expression of vascular cells. PGE1 is reported to be a pote...

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Bibliographic Details
Main Authors: Kengo Suzuki, Kenichiro Nishi, Satoshi Takabuchi, Shinichi Kai, Tomonori Matsuyama, Shin Kurosawa, Takehiko Adachi, Takayuki Maruyama, Kazuhiko Fukuda, Kiichi Hirota
Format: Article
Language:English
Published: PeerJ Inc. 2013-11-01
Series:PeerJ
Subjects:
Prostaglandin E1
Angiogenesis
VEGF
Hypoxia-inducible factor
EP receptor
Human endothelial cells
Online Access:https://peerj.com/articles/220.pdf

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