The association between iliac vein compression degree and characteristics of first diagnosed left lower extremity deep vein thrombosis
ObjectiveThis study aimed to investigate the association between the left common iliac vein (CIV) compression degree and characteristics of first diagnosed left lower extremity deep vein thrombosis (DVT).Patients and methodsThis was a single-center retrospective observational study. Between January...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1073586/full |
| _version_ | 1811289844692811776 |
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| author | Yadong Shi Yuan Yuan Maofeng Gong Haobo Su Liang Chen Hao Huang Zhaoxuan Lu Yangyi Zhou Jianping Gu |
| author_facet | Yadong Shi Yuan Yuan Maofeng Gong Haobo Su Liang Chen Hao Huang Zhaoxuan Lu Yangyi Zhou Jianping Gu |
| author_sort | Yadong Shi |
| collection | DOAJ |
| description | ObjectiveThis study aimed to investigate the association between the left common iliac vein (CIV) compression degree and characteristics of first diagnosed left lower extremity deep vein thrombosis (DVT).Patients and methodsThis was a single-center retrospective observational study. Between January 2015 and June 2022, first diagnosed left lower extremity DVT patients with enhanced computed tomography of lower extremities were included. Patient demographics, comorbidities, risk factors, DVT characteristics, and CIV compression degree were collected and analyzed. Logistic regressions were performed to evaluate the odds ratio (OR) with a 95% confidence interval (CI) of iliofemoral or mixed DVT vs. compression percentage. The association between compression percentage and iliofemoral or mixed DVT was evaluated on a continuous scale with restricted cubic splines (RCS). The association between compression percentage and thrombus burden was evaluated using the Spearman test.ResultsA total of 196 (mean age, 61.8 ± 16.1 years; 86 males) patients were included. The median CIV compression percentage in iliofemoral or mixed DVT patients was significantly greater than in non-iliofemoral or non-mixed DVT, respectively (64.4 vs. 46.6%, p < 0.001; 67.8 vs. 54.8%, p = 0.004). CIV compression >50% was associated with significantly increased morbidity of iliofemoral DVT (adjusted OR, 2.96; 95% CI, 1.58–5.52; p = 0.001) or mixed DVT (adjusted OR, 2.39; 95% CI, 1.19–4.81; p = 0.014). RCS showed that a greater compression percentage was associated with a continuously increased OR of iliofemoral DVT (overall p = 0.003, non-linear p = 0.577) or mixed DVT (overall p = 0.020, non-linear p = 0.771). CIV compression percentage had a positive correlation with thrombus burden (rs = 0.284, p < 0.001).ConclusionA greater left CIV compression percentage may be associated with increasing likelihood of more proximal location and severe clot extent in first diagnosed left lower extremity DVT. |
| first_indexed | 2024-04-13T04:01:34Z |
| format | Article |
| id | doaj.art-e20ec9bd3a244783837dd97f81c1c8e2 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-13T04:01:34Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-e20ec9bd3a244783837dd97f81c1c8e22022-12-22T03:03:28ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-12-01910.3389/fcvm.2022.10735861073586The association between iliac vein compression degree and characteristics of first diagnosed left lower extremity deep vein thrombosisYadong ShiYuan YuanMaofeng GongHaobo SuLiang ChenHao HuangZhaoxuan LuYangyi ZhouJianping GuObjectiveThis study aimed to investigate the association between the left common iliac vein (CIV) compression degree and characteristics of first diagnosed left lower extremity deep vein thrombosis (DVT).Patients and methodsThis was a single-center retrospective observational study. Between January 2015 and June 2022, first diagnosed left lower extremity DVT patients with enhanced computed tomography of lower extremities were included. Patient demographics, comorbidities, risk factors, DVT characteristics, and CIV compression degree were collected and analyzed. Logistic regressions were performed to evaluate the odds ratio (OR) with a 95% confidence interval (CI) of iliofemoral or mixed DVT vs. compression percentage. The association between compression percentage and iliofemoral or mixed DVT was evaluated on a continuous scale with restricted cubic splines (RCS). The association between compression percentage and thrombus burden was evaluated using the Spearman test.ResultsA total of 196 (mean age, 61.8 ± 16.1 years; 86 males) patients were included. The median CIV compression percentage in iliofemoral or mixed DVT patients was significantly greater than in non-iliofemoral or non-mixed DVT, respectively (64.4 vs. 46.6%, p < 0.001; 67.8 vs. 54.8%, p = 0.004). CIV compression >50% was associated with significantly increased morbidity of iliofemoral DVT (adjusted OR, 2.96; 95% CI, 1.58–5.52; p = 0.001) or mixed DVT (adjusted OR, 2.39; 95% CI, 1.19–4.81; p = 0.014). RCS showed that a greater compression percentage was associated with a continuously increased OR of iliofemoral DVT (overall p = 0.003, non-linear p = 0.577) or mixed DVT (overall p = 0.020, non-linear p = 0.771). CIV compression percentage had a positive correlation with thrombus burden (rs = 0.284, p < 0.001).ConclusionA greater left CIV compression percentage may be associated with increasing likelihood of more proximal location and severe clot extent in first diagnosed left lower extremity DVT.https://www.frontiersin.org/articles/10.3389/fcvm.2022.1073586/fulldeep vein thrombosiscommon iliac vein compressioncompression degreethrombus burdenMay-Thurner syndrome |
| spellingShingle | Yadong Shi Yuan Yuan Maofeng Gong Haobo Su Liang Chen Hao Huang Zhaoxuan Lu Yangyi Zhou Jianping Gu The association between iliac vein compression degree and characteristics of first diagnosed left lower extremity deep vein thrombosis Frontiers in Cardiovascular Medicine deep vein thrombosis common iliac vein compression compression degree thrombus burden May-Thurner syndrome |
| title | The association between iliac vein compression degree and characteristics of first diagnosed left lower extremity deep vein thrombosis |
| title_full | The association between iliac vein compression degree and characteristics of first diagnosed left lower extremity deep vein thrombosis |
| title_fullStr | The association between iliac vein compression degree and characteristics of first diagnosed left lower extremity deep vein thrombosis |
| title_full_unstemmed | The association between iliac vein compression degree and characteristics of first diagnosed left lower extremity deep vein thrombosis |
| title_short | The association between iliac vein compression degree and characteristics of first diagnosed left lower extremity deep vein thrombosis |
| title_sort | association between iliac vein compression degree and characteristics of first diagnosed left lower extremity deep vein thrombosis |
| topic | deep vein thrombosis common iliac vein compression compression degree thrombus burden May-Thurner syndrome |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1073586/full |
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