Mitigating Age-Related Cognitive Decline and Oxidative Status in Rats Treated with Catechin and Polyphenon-60
Aging is a normal physiological process influenced by the combination of multiple mechanisms, primarily oxidative stress and neuroinflammation, which impact general physiology and brain function. Phenolic compounds have demonstrated the ability to slow down the aging process of the brain due to thei...
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MDPI AG
2024-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/16/3/368 |
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| author | Silvia Tejada Fiorella Sarubbo Manuel Jiménez-García Margarida R. Ramis Margalida Monserrat-Mesquida Maria Magdalena Quetglas-Llabrés Xavier Capó Susana Esteban Antoni Sureda David Moranta |
| author_facet | Silvia Tejada Fiorella Sarubbo Manuel Jiménez-García Margarida R. Ramis Margalida Monserrat-Mesquida Maria Magdalena Quetglas-Llabrés Xavier Capó Susana Esteban Antoni Sureda David Moranta |
| author_sort | Silvia Tejada |
| collection | DOAJ |
| description | Aging is a normal physiological process influenced by the combination of multiple mechanisms, primarily oxidative stress and neuroinflammation, which impact general physiology and brain function. Phenolic compounds have demonstrated the ability to slow down the aging process of the brain due to their antioxidant and anti-inflammatory effects. This study assessed the protective properties of catechin and polyphenon-60 in non-pathologically aged rats regarding visuo-spatial learning and the oxidative status of the frontal cortex. Old animals were treated with catechin or green tea extract (polyphenon-60) for 36 days, daily. Healthy old and young rats were used as controls. During the first training phase, treated rats executed the test better, locating the target in less time compared with the controls. Biomarkers of oxidative stress (catalase activities, superoxide dismutase, glutathione reductase, and glutathione S-transferase) were reduced in the brain of old animals, although their activities were partially improved after both antioxidant treatments. Furthermore, the rise in the production of reactive oxygen species and malondialdehyde levels—a marker of lipid peroxidation—in the frontal cortex of aged animals was significantly ameliorated after the interventions. In conclusion, old rats exhibited enhanced cognitive function and reduced stress levels following the administration of catechin and polyphenon-60. |
| first_indexed | 2024-03-08T03:52:12Z |
| format | Article |
| id | doaj.art-e211268e88df44abae17bc709f562c4d |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-08T03:52:12Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-e211268e88df44abae17bc709f562c4d2024-02-09T15:19:44ZengMDPI AGNutrients2072-66432024-01-0116336810.3390/nu16030368Mitigating Age-Related Cognitive Decline and Oxidative Status in Rats Treated with Catechin and Polyphenon-60Silvia Tejada0Fiorella Sarubbo1Manuel Jiménez-García2Margarida R. Ramis3Margalida Monserrat-Mesquida4Maria Magdalena Quetglas-Llabrés5Xavier Capó6Susana Esteban7Antoni Sureda8David Moranta9Laboratory of Neurophysiology, University of the Balearic Islands, 07122 Palma de Mallorca, SpainLaboratory of Neurophysiology, University of the Balearic Islands, 07122 Palma de Mallorca, SpainLaboratory of Neurophysiology, University of the Balearic Islands, 07122 Palma de Mallorca, SpainLaboratory of Neurophysiology, University of the Balearic Islands, 07122 Palma de Mallorca, SpainHealth Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, SpainHealth Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, SpainHealth Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, SpainLaboratory of Neurophysiology, University of the Balearic Islands, 07122 Palma de Mallorca, SpainCIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, SpainLaboratory of Neurophysiology, University of the Balearic Islands, 07122 Palma de Mallorca, SpainAging is a normal physiological process influenced by the combination of multiple mechanisms, primarily oxidative stress and neuroinflammation, which impact general physiology and brain function. Phenolic compounds have demonstrated the ability to slow down the aging process of the brain due to their antioxidant and anti-inflammatory effects. This study assessed the protective properties of catechin and polyphenon-60 in non-pathologically aged rats regarding visuo-spatial learning and the oxidative status of the frontal cortex. Old animals were treated with catechin or green tea extract (polyphenon-60) for 36 days, daily. Healthy old and young rats were used as controls. During the first training phase, treated rats executed the test better, locating the target in less time compared with the controls. Biomarkers of oxidative stress (catalase activities, superoxide dismutase, glutathione reductase, and glutathione S-transferase) were reduced in the brain of old animals, although their activities were partially improved after both antioxidant treatments. Furthermore, the rise in the production of reactive oxygen species and malondialdehyde levels—a marker of lipid peroxidation—in the frontal cortex of aged animals was significantly ameliorated after the interventions. In conclusion, old rats exhibited enhanced cognitive function and reduced stress levels following the administration of catechin and polyphenon-60.https://www.mdpi.com/2072-6643/16/3/368antioxidant enzymesBarnes maze testcognitive declinelipidic damagepolyphenols |
| spellingShingle | Silvia Tejada Fiorella Sarubbo Manuel Jiménez-García Margarida R. Ramis Margalida Monserrat-Mesquida Maria Magdalena Quetglas-Llabrés Xavier Capó Susana Esteban Antoni Sureda David Moranta Mitigating Age-Related Cognitive Decline and Oxidative Status in Rats Treated with Catechin and Polyphenon-60 Nutrients antioxidant enzymes Barnes maze test cognitive decline lipidic damage polyphenols |
| title | Mitigating Age-Related Cognitive Decline and Oxidative Status in Rats Treated with Catechin and Polyphenon-60 |
| title_full | Mitigating Age-Related Cognitive Decline and Oxidative Status in Rats Treated with Catechin and Polyphenon-60 |
| title_fullStr | Mitigating Age-Related Cognitive Decline and Oxidative Status in Rats Treated with Catechin and Polyphenon-60 |
| title_full_unstemmed | Mitigating Age-Related Cognitive Decline and Oxidative Status in Rats Treated with Catechin and Polyphenon-60 |
| title_short | Mitigating Age-Related Cognitive Decline and Oxidative Status in Rats Treated with Catechin and Polyphenon-60 |
| title_sort | mitigating age related cognitive decline and oxidative status in rats treated with catechin and polyphenon 60 |
| topic | antioxidant enzymes Barnes maze test cognitive decline lipidic damage polyphenols |
| url | https://www.mdpi.com/2072-6643/16/3/368 |
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