Selective If-channel inhibitor ivabradine in the treatment of sinus tachycardia in coronary heart disease patients with acute heart failure and inferior myocardial infarction
Aim. To assess the effectiveness of ivabradine therapy in heart rate (HR) reduction among patients with acute heart failure (AHF). Material and methods. ОIn total, 40 dopamine-treated patients with inferior myocardial infarction (MI) were examined. All participants were randomised into Groups A (n=2...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2010-06-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/2085 |
| _version_ | 1797882631279345664 |
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| author | S. A. Sayganov Yu. N. Grishkin |
| author_facet | S. A. Sayganov Yu. N. Grishkin |
| author_sort | S. A. Sayganov |
| collection | DOAJ |
| description | Aim. To assess the effectiveness of ivabradine therapy in heart rate (HR) reduction among patients with acute heart failure (AHF). Material and methods. ОIn total, 40 dopamine-treated patients with inferior myocardial infarction (MI) were examined. All participants were randomised into Groups A (n=21; ivabradine dose 10-20 mg/d) and B (n=19; controls). In all patients, HR was measured, and echocardiography was performed. Results. In Group A, HR decreased as early as 12 hours after the start of ivabradine therapy, from 106,4±2,7 to 98,5±2,8 bpm (p<0,05), while in Group B, no HR reduction was observed in the first 24 hours. By Day 14, HR was reduced in both groups. In Group A, however, it was significantly lower — 81,5±1,8 vs. 91,6±2,5 bpm (p<0,001), despite similar baseline HR levels. According to the echocardiography results, Group A demonstrated an increase in left ventricular ejection fraction (LV EF), from 29,4±1,7 to 34,9±1,8 % (р<0,05), without LV dilatation. In Group B, no LV EF increase was observed by Day 14, and LV size increased from 56,8±1,1 to 60,5±1,2 mm (p<0,005). Conclusion. Ivabradine reduced HR in AHF, which was associated with improved LV contractility and prevented further LV dilatation. |
| first_indexed | 2024-04-10T03:38:53Z |
| format | Article |
| id | doaj.art-e21184fa30ee49f7b23602a049c8b6eb |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:38:53Z |
| publishDate | 2010-06-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-e21184fa30ee49f7b23602a049c8b6eb2023-03-13T07:23:18Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252010-06-019352561796Selective If-channel inhibitor ivabradine in the treatment of sinus tachycardia in coronary heart disease patients with acute heart failure and inferior myocardial infarctionS. A. Sayganov0Yu. N. Grishkin1ГОУ ДПО Санкт-Петербургская медицинская академия последипломного образования Росздрава. Санкт-ПетербургГОУ ДПО Санкт-Петербургская медицинская академия последипломного образования Росздрава. Санкт-ПетербургAim. To assess the effectiveness of ivabradine therapy in heart rate (HR) reduction among patients with acute heart failure (AHF). Material and methods. ОIn total, 40 dopamine-treated patients with inferior myocardial infarction (MI) were examined. All participants were randomised into Groups A (n=21; ivabradine dose 10-20 mg/d) and B (n=19; controls). In all patients, HR was measured, and echocardiography was performed. Results. In Group A, HR decreased as early as 12 hours after the start of ivabradine therapy, from 106,4±2,7 to 98,5±2,8 bpm (p<0,05), while in Group B, no HR reduction was observed in the first 24 hours. By Day 14, HR was reduced in both groups. In Group A, however, it was significantly lower — 81,5±1,8 vs. 91,6±2,5 bpm (p<0,001), despite similar baseline HR levels. According to the echocardiography results, Group A demonstrated an increase in left ventricular ejection fraction (LV EF), from 29,4±1,7 to 34,9±1,8 % (р<0,05), without LV dilatation. In Group B, no LV EF increase was observed by Day 14, and LV size increased from 56,8±1,1 to 60,5±1,2 mm (p<0,005). Conclusion. Ivabradine reduced HR in AHF, which was associated with improved LV contractility and prevented further LV dilatation.https://cardiovascular.elpub.ru/jour/article/view/2085острая сердечная недостаточностьинфаркт миокардаивабрадинсинусовая тахикардия |
| spellingShingle | S. A. Sayganov Yu. N. Grishkin Selective If-channel inhibitor ivabradine in the treatment of sinus tachycardia in coronary heart disease patients with acute heart failure and inferior myocardial infarction Кардиоваскулярная терапия и профилактика острая сердечная недостаточность инфаркт миокарда ивабрадин синусовая тахикардия |
| title | Selective If-channel inhibitor ivabradine in the treatment of sinus tachycardia in coronary heart disease patients with acute heart failure and inferior myocardial infarction |
| title_full | Selective If-channel inhibitor ivabradine in the treatment of sinus tachycardia in coronary heart disease patients with acute heart failure and inferior myocardial infarction |
| title_fullStr | Selective If-channel inhibitor ivabradine in the treatment of sinus tachycardia in coronary heart disease patients with acute heart failure and inferior myocardial infarction |
| title_full_unstemmed | Selective If-channel inhibitor ivabradine in the treatment of sinus tachycardia in coronary heart disease patients with acute heart failure and inferior myocardial infarction |
| title_short | Selective If-channel inhibitor ivabradine in the treatment of sinus tachycardia in coronary heart disease patients with acute heart failure and inferior myocardial infarction |
| title_sort | selective if channel inhibitor ivabradine in the treatment of sinus tachycardia in coronary heart disease patients with acute heart failure and inferior myocardial infarction |
| topic | острая сердечная недостаточность инфаркт миокарда ивабрадин синусовая тахикардия |
| url | https://cardiovascular.elpub.ru/jour/article/view/2085 |
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