Characteristics, Structure, and Biological Role of Stefins (type-1 cystatins) of Human, Mammal, and Parasite Origin
The majority of lysosomal cysteine cathepsins are ubiquitously expressed enzymes. However, some of them differ in their specific cell or tissue distribution and substrate specificity, suggesting their involvement in determining normal cellular processes, as well as pathologies. Their proteolytic act...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Slovenian Chemical Society
2019-02-01
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| Series: | Acta Chimica Slovenica |
| Subjects: | |
| Online Access: | https://journals.matheo.si/index.php/ACSi/article/view/4639 |
| _version_ | 1818047163251294208 |
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| author | Vito Turk Dušan Turk Iztok Dolenc Veronika Stoka |
| author_facet | Vito Turk Dušan Turk Iztok Dolenc Veronika Stoka |
| author_sort | Vito Turk |
| collection | DOAJ |
| description | The majority of lysosomal cysteine cathepsins are ubiquitously expressed enzymes. However, some of them differ in their specific cell or tissue distribution and substrate specificity, suggesting their involvement in determining normal cellular processes, as well as pathologies. Their proteolytic activities are potentially harmful if uncontrolled. Therefore, living organisms have developed several regulatory mechanisms such as endogenous protein inhibitors of the cystatin family, including the group of small cytosolic proteins, the stefins. The main focus of this review is stefins of various origins and their properties, structure, and mechanism of interaction with their target enzymes. Furthermore, oligomerization and fibrillogenesis in stefins and/or cystatins provide insights into conformational diseases. The present status of the knowledge in this field and current trends might contribute to identifying novel therapeutic targets and approaches to treat various diseases. |
| first_indexed | 2024-12-10T10:01:25Z |
| format | Article |
| id | doaj.art-e211c4f4b1264a649a13a9ac248234a5 |
| institution | Directory Open Access Journal |
| issn | 1318-0207 1580-3155 |
| language | English |
| last_indexed | 2024-12-10T10:01:25Z |
| publishDate | 2019-02-01 |
| publisher | Slovenian Chemical Society |
| record_format | Article |
| series | Acta Chimica Slovenica |
| spelling | doaj.art-e211c4f4b1264a649a13a9ac248234a52022-12-22T01:53:20ZengSlovenian Chemical SocietyActa Chimica Slovenica1318-02071580-31552019-02-0166151710.17344/acsi.2018.4639630Characteristics, Structure, and Biological Role of Stefins (type-1 cystatins) of Human, Mammal, and Parasite OriginVito Turk0Dušan Turk1Iztok Dolenc2Veronika Stoka3Jožef Stefan Institute Jožef Stefan International Postgraduate SchoolJožef Stefan Institute Centre of Excellence CIPKEBIPJožef Stefan InstituteJožef Stefan Institute Jožef Stefan International Postgraduate SchoolThe majority of lysosomal cysteine cathepsins are ubiquitously expressed enzymes. However, some of them differ in their specific cell or tissue distribution and substrate specificity, suggesting their involvement in determining normal cellular processes, as well as pathologies. Their proteolytic activities are potentially harmful if uncontrolled. Therefore, living organisms have developed several regulatory mechanisms such as endogenous protein inhibitors of the cystatin family, including the group of small cytosolic proteins, the stefins. The main focus of this review is stefins of various origins and their properties, structure, and mechanism of interaction with their target enzymes. Furthermore, oligomerization and fibrillogenesis in stefins and/or cystatins provide insights into conformational diseases. The present status of the knowledge in this field and current trends might contribute to identifying novel therapeutic targets and approaches to treat various diseases.https://journals.matheo.si/index.php/ACSi/article/view/4639mammalian stefinsparasite stefinscystatinscysteine cathepsinsmechanism of interactionoligomerization |
| spellingShingle | Vito Turk Dušan Turk Iztok Dolenc Veronika Stoka Characteristics, Structure, and Biological Role of Stefins (type-1 cystatins) of Human, Mammal, and Parasite Origin Acta Chimica Slovenica mammalian stefins parasite stefins cystatins cysteine cathepsins mechanism of interaction oligomerization |
| title | Characteristics, Structure, and Biological Role of Stefins (type-1 cystatins) of Human, Mammal, and Parasite Origin |
| title_full | Characteristics, Structure, and Biological Role of Stefins (type-1 cystatins) of Human, Mammal, and Parasite Origin |
| title_fullStr | Characteristics, Structure, and Biological Role of Stefins (type-1 cystatins) of Human, Mammal, and Parasite Origin |
| title_full_unstemmed | Characteristics, Structure, and Biological Role of Stefins (type-1 cystatins) of Human, Mammal, and Parasite Origin |
| title_short | Characteristics, Structure, and Biological Role of Stefins (type-1 cystatins) of Human, Mammal, and Parasite Origin |
| title_sort | characteristics structure and biological role of stefins type 1 cystatins of human mammal and parasite origin |
| topic | mammalian stefins parasite stefins cystatins cysteine cathepsins mechanism of interaction oligomerization |
| url | https://journals.matheo.si/index.php/ACSi/article/view/4639 |
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