Role of Amine Neurotransmitters and Their Receptors in Skin Pigmentation: Therapeutic Implication
Skin pigmentation can occur due to increased melanin, including melanocyte proliferation, melanin biosynthesis, or melanocyte migration. There are many factors that influence the melanin production process, but the role of neurotransmitters in this process is still unclear. We found that histamine a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/15/8071 |
| _version_ | 1797525548280315904 |
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| author | Enkhmend Enkhtaivan Chang Hoon Lee |
| author_facet | Enkhmend Enkhtaivan Chang Hoon Lee |
| author_sort | Enkhmend Enkhtaivan |
| collection | DOAJ |
| description | Skin pigmentation can occur due to increased melanin, including melanocyte proliferation, melanin biosynthesis, or melanocyte migration. There are many factors that influence the melanin production process, but the role of neurotransmitters in this process is still unclear. We found that histamine and serotonin influence the different stages of melanogenesis and melanogenesis, which increase melanogenesis. Since then, several related papers have been published, and from these papers, it has been recognised that the role of neurotransmitters in skin-pigment-related diseases needs to be summarised. By introducing the role of neurotransmitters in the regulation of various pigment disorders, including vitiligo and melasma, through this review, many researchers can be expected to try to apply neurotransmitter-related agonists and antagonists as treatments for skin pigment disorders. |
| first_indexed | 2024-03-10T09:15:25Z |
| format | Article |
| id | doaj.art-e211ec9e7dff4c7285a1fbd57d68ae59 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T09:15:25Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e211ec9e7dff4c7285a1fbd57d68ae592023-11-22T05:42:48ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-07-012215807110.3390/ijms22158071Role of Amine Neurotransmitters and Their Receptors in Skin Pigmentation: Therapeutic ImplicationEnkhmend Enkhtaivan0Chang Hoon Lee1College of Pharmacy, Dongguk University, Seoul 04620, KoreaCollege of Pharmacy, Dongguk University, Seoul 04620, KoreaSkin pigmentation can occur due to increased melanin, including melanocyte proliferation, melanin biosynthesis, or melanocyte migration. There are many factors that influence the melanin production process, but the role of neurotransmitters in this process is still unclear. We found that histamine and serotonin influence the different stages of melanogenesis and melanogenesis, which increase melanogenesis. Since then, several related papers have been published, and from these papers, it has been recognised that the role of neurotransmitters in skin-pigment-related diseases needs to be summarised. By introducing the role of neurotransmitters in the regulation of various pigment disorders, including vitiligo and melasma, through this review, many researchers can be expected to try to apply neurotransmitter-related agonists and antagonists as treatments for skin pigment disorders.https://www.mdpi.com/1422-0067/22/15/8071serotoninhistamimeacetylcholinedopaminevitiligomelanogenesis |
| spellingShingle | Enkhmend Enkhtaivan Chang Hoon Lee Role of Amine Neurotransmitters and Their Receptors in Skin Pigmentation: Therapeutic Implication International Journal of Molecular Sciences serotonin histamime acetylcholine dopamine vitiligo melanogenesis |
| title | Role of Amine Neurotransmitters and Their Receptors in Skin Pigmentation: Therapeutic Implication |
| title_full | Role of Amine Neurotransmitters and Their Receptors in Skin Pigmentation: Therapeutic Implication |
| title_fullStr | Role of Amine Neurotransmitters and Their Receptors in Skin Pigmentation: Therapeutic Implication |
| title_full_unstemmed | Role of Amine Neurotransmitters and Their Receptors in Skin Pigmentation: Therapeutic Implication |
| title_short | Role of Amine Neurotransmitters and Their Receptors in Skin Pigmentation: Therapeutic Implication |
| title_sort | role of amine neurotransmitters and their receptors in skin pigmentation therapeutic implication |
| topic | serotonin histamime acetylcholine dopamine vitiligo melanogenesis |
| url | https://www.mdpi.com/1422-0067/22/15/8071 |
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