Detecting age-related changes in skeletal muscle mechanics using ultrasound shear wave elastography
Abstract Aging leads to a decline in muscle mass and force-generating capacity. Ultrasound shear wave elastography (SWE) is a non-invasive method to capture age-related muscular adaptation. This study assessed biceps brachii muscle (BB) mechanics, hypothesizing that shear elastic modulus reflects (i...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-47468-z |
| _version_ | 1797560226421932032 |
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| author | Filiz Ateş Justus Marquetand Manuela Zimmer |
| author_facet | Filiz Ateş Justus Marquetand Manuela Zimmer |
| author_sort | Filiz Ateş |
| collection | DOAJ |
| description | Abstract Aging leads to a decline in muscle mass and force-generating capacity. Ultrasound shear wave elastography (SWE) is a non-invasive method to capture age-related muscular adaptation. This study assessed biceps brachii muscle (BB) mechanics, hypothesizing that shear elastic modulus reflects (i) passive muscle force increase imposed by length change, (ii) activation-dependent mechanical changes, and (iii) differences between older and younger individuals. Fourteen healthy volunteers aged 60–80 participated. Shear elastic modulus, surface electromyography, and elbow torque were measured at five elbow positions in passive and active states. Data collected from young adults aged 20–40 were compared. The BB passive shear elastic modulus increased from flexion to extension, with the older group exhibiting up to 52.58% higher values. Maximum elbow flexion torque decreased in extended positions, with the older group 23.67% weaker. Significant effects of elbow angle, activity level, and age on total and active shear elastic modulus were found during submaximal contractions. The older group had 20.25% lower active shear elastic modulus at 25% maximum voluntary contraction. SWE effectively quantified passive and activation-dependent BB mechanics, detecting age-related alterations at rest and during low-level activities. These findings suggest shear elastic modulus as a promising biomarker for identifying altered muscle mechanics in aging. |
| first_indexed | 2024-03-10T17:57:26Z |
| format | Article |
| id | doaj.art-e211efee06c04889a6a7926c4ec9b6ae |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T17:57:26Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e211efee06c04889a6a7926c4ec9b6ae2023-11-20T09:10:38ZengNature PortfolioScientific Reports2045-23222023-11-0113111110.1038/s41598-023-47468-zDetecting age-related changes in skeletal muscle mechanics using ultrasound shear wave elastographyFiliz Ateş0Justus Marquetand1Manuela Zimmer2Institute of Structural Mechanics and Dynamics in Aerospace Engineering, University of StuttgartDepartment of Epileptology, Hertie-Institute for Clinical Brain Research, University of TübingenInstitute of Structural Mechanics and Dynamics in Aerospace Engineering, University of StuttgartAbstract Aging leads to a decline in muscle mass and force-generating capacity. Ultrasound shear wave elastography (SWE) is a non-invasive method to capture age-related muscular adaptation. This study assessed biceps brachii muscle (BB) mechanics, hypothesizing that shear elastic modulus reflects (i) passive muscle force increase imposed by length change, (ii) activation-dependent mechanical changes, and (iii) differences between older and younger individuals. Fourteen healthy volunteers aged 60–80 participated. Shear elastic modulus, surface electromyography, and elbow torque were measured at five elbow positions in passive and active states. Data collected from young adults aged 20–40 were compared. The BB passive shear elastic modulus increased from flexion to extension, with the older group exhibiting up to 52.58% higher values. Maximum elbow flexion torque decreased in extended positions, with the older group 23.67% weaker. Significant effects of elbow angle, activity level, and age on total and active shear elastic modulus were found during submaximal contractions. The older group had 20.25% lower active shear elastic modulus at 25% maximum voluntary contraction. SWE effectively quantified passive and activation-dependent BB mechanics, detecting age-related alterations at rest and during low-level activities. These findings suggest shear elastic modulus as a promising biomarker for identifying altered muscle mechanics in aging.https://doi.org/10.1038/s41598-023-47468-z |
| spellingShingle | Filiz Ateş Justus Marquetand Manuela Zimmer Detecting age-related changes in skeletal muscle mechanics using ultrasound shear wave elastography Scientific Reports |
| title | Detecting age-related changes in skeletal muscle mechanics using ultrasound shear wave elastography |
| title_full | Detecting age-related changes in skeletal muscle mechanics using ultrasound shear wave elastography |
| title_fullStr | Detecting age-related changes in skeletal muscle mechanics using ultrasound shear wave elastography |
| title_full_unstemmed | Detecting age-related changes in skeletal muscle mechanics using ultrasound shear wave elastography |
| title_short | Detecting age-related changes in skeletal muscle mechanics using ultrasound shear wave elastography |
| title_sort | detecting age related changes in skeletal muscle mechanics using ultrasound shear wave elastography |
| url | https://doi.org/10.1038/s41598-023-47468-z |
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