Sepsis-Induced Gut Dysbiosis Mediates the Susceptibility to Sepsis-Associated Encephalopathy in Mice

Sepsis-Induced Gut Dysbiosis Mediates the Susceptibility to Sepsis-Associated Encephalopathy in Mice

ABSTRACT Sepsis-associated encephalopathy (SAE) is common in septic patients and is associated with adverse outcomes. The gut microbiota has been recognized as a key mediator of neurological disease development. However, the exact role of the gut microbiota in regulating SAE remains elusive. Here, w...

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Bibliographic Details
Main Authors: Heng Fang, Yirong Wang, Jia Deng, Huidan Zhang, Qingrui Wu, Linling He, Jing Xu, Xin Shao, Xin Ouyang, Zhimei He, Qiuping Zhou, Huifang Wang, Yiyu Deng, Chunbo Chen
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:mSystems
Subjects:
gut microbiota
sepsis-associated encephalopathy
indole-3-propionic acid
microglia
Online Access:https://journals.asm.org/doi/10.1128/msystems.01399-21

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