Is Age a Limitation for Organ Donation? A Comparison of Elderly and Non-elderly Donors in a Deceased Donor Organ Transplantation Program from South India
To bridge the gap between demand and supply of organs, deceased donors with extreme ages can be utilized. The object of this study was to compare elderly with non-elderly donors and to assess the predictors of organ utilization or wastage. This was a retrospective chart analysis. Univariate and mult...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Saudi Journal of Kidney Diseases and Transplantation |
| Online Access: | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2022;volume=33;issue=8;spage=231;epage=240;aulast=Kiran |
| _version_ | 1797645400356683776 |
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| author | Banigallapati Vijay Kiran Kalidindi Raja Karthik Guditi Swarnalatha Tanduri Gangadhar Sree Bhushan Raju Bhrugumalla Sukanya Nagari Beerappa |
| author_facet | Banigallapati Vijay Kiran Kalidindi Raja Karthik Guditi Swarnalatha Tanduri Gangadhar Sree Bhushan Raju Bhrugumalla Sukanya Nagari Beerappa |
| author_sort | Banigallapati Vijay Kiran |
| collection | DOAJ |
| description | To bridge the gap between demand and supply of organs, deceased donors with extreme ages can be utilized. The object of this study was to compare elderly with non-elderly donors and to assess the predictors of organ utilization or wastage. This was a retrospective chart analysis. Univariate and multivariate logistic regression analysis of cohorts was carried out to predict organ utilization or wastage. Of the 716 deceased donors, 16.2% were elderly (≥60 years) and 83.8% were not elderly (≤59 years). Donors in the elderly cohort were more likely to be diabetic, hypertensive, overweight, and smokers compared with non-elderly donors. They had deranged terminal creatinine and succumbed to cerebrovascular accident or intracerebral hemorrhage. They had a high kidney donor risk index (KDRI) of 1.83 ± 0.46. Those in the younger donor cohort, were more likely to have succumbed to road traffic accident-associated traumatic brain injury, were subjected to more efforts to revive them in the intensive care unit via cardiopulmonary resuscitation, had deranged liver function tests, and had a KDRI of 0.93 ± 0.28. The kidney discard rate (KDR) and liver discard rate (LDR) in the elderly donors was 50% and 8.6%, respectively (vis-a-vis the non-elderly at 13.3 % and 7.5%). The KDR was significantly higher than the LDR in elderly donors. The main reason for this was the high number of “marginal kidneys”. We revealed that elderly donors formed a significant proportion of deceased donors. The utilization of the liver from deceased donors was more frequent compared with the kidney. |
| first_indexed | 2024-03-11T14:45:47Z |
| format | Article |
| id | doaj.art-e2145df4d496456a9c78d54298cb8202 |
| institution | Directory Open Access Journal |
| issn | 1319-2442 |
| language | English |
| last_indexed | 2024-03-11T14:45:47Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Kidney Diseases and Transplantation |
| spelling | doaj.art-e2145df4d496456a9c78d54298cb82022023-10-30T11:57:50ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422022-01-0133823124010.4103/1319-2442.384192Is Age a Limitation for Organ Donation? A Comparison of Elderly and Non-elderly Donors in a Deceased Donor Organ Transplantation Program from South IndiaBanigallapati Vijay KiranKalidindi Raja KarthikGuditi SwarnalathaTanduri GangadharSree Bhushan RajuBhrugumalla SukanyaNagari BeerappaTo bridge the gap between demand and supply of organs, deceased donors with extreme ages can be utilized. The object of this study was to compare elderly with non-elderly donors and to assess the predictors of organ utilization or wastage. This was a retrospective chart analysis. Univariate and multivariate logistic regression analysis of cohorts was carried out to predict organ utilization or wastage. Of the 716 deceased donors, 16.2% were elderly (≥60 years) and 83.8% were not elderly (≤59 years). Donors in the elderly cohort were more likely to be diabetic, hypertensive, overweight, and smokers compared with non-elderly donors. They had deranged terminal creatinine and succumbed to cerebrovascular accident or intracerebral hemorrhage. They had a high kidney donor risk index (KDRI) of 1.83 ± 0.46. Those in the younger donor cohort, were more likely to have succumbed to road traffic accident-associated traumatic brain injury, were subjected to more efforts to revive them in the intensive care unit via cardiopulmonary resuscitation, had deranged liver function tests, and had a KDRI of 0.93 ± 0.28. The kidney discard rate (KDR) and liver discard rate (LDR) in the elderly donors was 50% and 8.6%, respectively (vis-a-vis the non-elderly at 13.3 % and 7.5%). The KDR was significantly higher than the LDR in elderly donors. The main reason for this was the high number of “marginal kidneys”. We revealed that elderly donors formed a significant proportion of deceased donors. The utilization of the liver from deceased donors was more frequent compared with the kidney.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2022;volume=33;issue=8;spage=231;epage=240;aulast=Kiran |
| spellingShingle | Banigallapati Vijay Kiran Kalidindi Raja Karthik Guditi Swarnalatha Tanduri Gangadhar Sree Bhushan Raju Bhrugumalla Sukanya Nagari Beerappa Is Age a Limitation for Organ Donation? A Comparison of Elderly and Non-elderly Donors in a Deceased Donor Organ Transplantation Program from South India Saudi Journal of Kidney Diseases and Transplantation |
| title | Is Age a Limitation for Organ Donation? A Comparison of Elderly and Non-elderly Donors in a Deceased Donor Organ Transplantation Program from South India |
| title_full | Is Age a Limitation for Organ Donation? A Comparison of Elderly and Non-elderly Donors in a Deceased Donor Organ Transplantation Program from South India |
| title_fullStr | Is Age a Limitation for Organ Donation? A Comparison of Elderly and Non-elderly Donors in a Deceased Donor Organ Transplantation Program from South India |
| title_full_unstemmed | Is Age a Limitation for Organ Donation? A Comparison of Elderly and Non-elderly Donors in a Deceased Donor Organ Transplantation Program from South India |
| title_short | Is Age a Limitation for Organ Donation? A Comparison of Elderly and Non-elderly Donors in a Deceased Donor Organ Transplantation Program from South India |
| title_sort | is age a limitation for organ donation a comparison of elderly and non elderly donors in a deceased donor organ transplantation program from south india |
| url | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2022;volume=33;issue=8;spage=231;epage=240;aulast=Kiran |
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