Relationship between antibiotic exposure and carbapenem-resistant Klebsiella pneumoniae infection within four types of control patients: A systematic review and meta-analysis
ABSTRACT: Objectives: This study attempted to identify the relationship between antibiotic exposure and risk of carbapenem-resistant Klebsiella pneumoniae (CRKP) infection. Methods: Antibiotic exposure was analysed as a risk factor for CRKP infection, cases of which were extracted from research art...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Journal of Global Antimicrobial Resistance |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716523000334 |
| _version_ | 1797802272868007936 |
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| author | Lin Zhu Le Liang Jiaojiao Hui Jian Lu Rui Yang Qingqing He Nani Tian Ting Bai Xiao Li |
| author_facet | Lin Zhu Le Liang Jiaojiao Hui Jian Lu Rui Yang Qingqing He Nani Tian Ting Bai Xiao Li |
| author_sort | Lin Zhu |
| collection | DOAJ |
| description | ABSTRACT: Objectives: This study attempted to identify the relationship between antibiotic exposure and risk of carbapenem-resistant Klebsiella pneumoniae (CRKP) infection. Methods: Antibiotic exposure was analysed as a risk factor for CRKP infection, cases of which were extracted from research articles indexed in PubMed, EMBASE, and the Cochrane Library. Relevant studies published until January 2023 were reviewed, and a meta-analysis was conducted on antibiotic exposure within four types of control groups, which comprised 52 studies. Results: The four types of control groups included carbapenem-susceptible K. pneumoniae infections (CSKP; comparison 1); other infections, especially without CRKP infection (comparison 2); CRKP colonisation (comparison 3); and no infection (comparison 4). Carbapenems exposure and Aminoglycosides exposure were two risk factors common to the four comparison groups. Compared with the risk of CSKP infection, tigecycline exposure in bloodstream infections and quinolone exposure within 30 days were associated with an increased risk of CRKP infection. However, the risk of CRKP infection associated with tigecycline exposure in mixed (MIX) infections (infections involving two or more different infection sites) and quinolone exposure within 90 days was similar to the risk of CSKP infection. Conclusion: Carbapenems and Aminoglycosides exposure are likely risk factors for CRKP infection. Antibiotic exposure time as a continuous variable was not associated with the risk of CRKP infection, compared with the risk of CSKP infection. Tigecycline exposure in MIX infections and quinolone exposure within 90 days may not increase the risk of CRKP infection. |
| first_indexed | 2024-03-13T05:03:17Z |
| format | Article |
| id | doaj.art-e21469ec6ac2456a9ffa63e958a95295 |
| institution | Directory Open Access Journal |
| issn | 2213-7165 |
| language | English |
| last_indexed | 2024-03-13T05:03:17Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj.art-e21469ec6ac2456a9ffa63e958a952952023-06-17T05:18:26ZengElsevierJournal of Global Antimicrobial Resistance2213-71652023-06-0133137151Relationship between antibiotic exposure and carbapenem-resistant Klebsiella pneumoniae infection within four types of control patients: A systematic review and meta-analysisLin Zhu0Le Liang1Jiaojiao Hui2Jian Lu3Rui Yang4Qingqing He5Nani Tian6Ting Bai7Xiao Li8Corresponding author at: Department of Clinical Pharmacy, The First People's Hospital of Xianyang, 712000, Xianyang, Shaanxi, P.R. China.; Department of Clinical Pharmacy, The First People's Hospital of Xianyang, 712000, Xianyang, Shaanxi, P.R. ChinaDepartment of Clinical Pharmacy, The First People's Hospital of Xianyang, 712000, Xianyang, Shaanxi, P.R. ChinaDepartment of Clinical Pharmacy, The First People's Hospital of Xianyang, 712000, Xianyang, Shaanxi, P.R. ChinaDepartment of Clinical Pharmacy, The First People's Hospital of Xianyang, 712000, Xianyang, Shaanxi, P.R. ChinaDepartment of Clinical Pharmacy, The First People's Hospital of Xianyang, 712000, Xianyang, Shaanxi, P.R. ChinaDepartment of Clinical Pharmacy, The First People's Hospital of Xianyang, 712000, Xianyang, Shaanxi, P.R. ChinaDepartment of Clinical Pharmacy, The First People's Hospital of Xianyang, 712000, Xianyang, Shaanxi, P.R. ChinaDepartment of Clinical Pharmacy, The First People's Hospital of Xianyang, 712000, Xianyang, Shaanxi, P.R. ChinaDepartment of Clinical Pharmacy, The First People's Hospital of Xianyang, 712000, Xianyang, Shaanxi, P.R. ChinaABSTRACT: Objectives: This study attempted to identify the relationship between antibiotic exposure and risk of carbapenem-resistant Klebsiella pneumoniae (CRKP) infection. Methods: Antibiotic exposure was analysed as a risk factor for CRKP infection, cases of which were extracted from research articles indexed in PubMed, EMBASE, and the Cochrane Library. Relevant studies published until January 2023 were reviewed, and a meta-analysis was conducted on antibiotic exposure within four types of control groups, which comprised 52 studies. Results: The four types of control groups included carbapenem-susceptible K. pneumoniae infections (CSKP; comparison 1); other infections, especially without CRKP infection (comparison 2); CRKP colonisation (comparison 3); and no infection (comparison 4). Carbapenems exposure and Aminoglycosides exposure were two risk factors common to the four comparison groups. Compared with the risk of CSKP infection, tigecycline exposure in bloodstream infections and quinolone exposure within 30 days were associated with an increased risk of CRKP infection. However, the risk of CRKP infection associated with tigecycline exposure in mixed (MIX) infections (infections involving two or more different infection sites) and quinolone exposure within 90 days was similar to the risk of CSKP infection. Conclusion: Carbapenems and Aminoglycosides exposure are likely risk factors for CRKP infection. Antibiotic exposure time as a continuous variable was not associated with the risk of CRKP infection, compared with the risk of CSKP infection. Tigecycline exposure in MIX infections and quinolone exposure within 90 days may not increase the risk of CRKP infection.http://www.sciencedirect.com/science/article/pii/S2213716523000334Carbapenem-resistant Klebsiella pneumoniaAntibiotic exposureRisk factorReview and meta-analysis |
| spellingShingle | Lin Zhu Le Liang Jiaojiao Hui Jian Lu Rui Yang Qingqing He Nani Tian Ting Bai Xiao Li Relationship between antibiotic exposure and carbapenem-resistant Klebsiella pneumoniae infection within four types of control patients: A systematic review and meta-analysis Journal of Global Antimicrobial Resistance Carbapenem-resistant Klebsiella pneumonia Antibiotic exposure Risk factor Review and meta-analysis |
| title | Relationship between antibiotic exposure and carbapenem-resistant Klebsiella pneumoniae infection within four types of control patients: A systematic review and meta-analysis |
| title_full | Relationship between antibiotic exposure and carbapenem-resistant Klebsiella pneumoniae infection within four types of control patients: A systematic review and meta-analysis |
| title_fullStr | Relationship between antibiotic exposure and carbapenem-resistant Klebsiella pneumoniae infection within four types of control patients: A systematic review and meta-analysis |
| title_full_unstemmed | Relationship between antibiotic exposure and carbapenem-resistant Klebsiella pneumoniae infection within four types of control patients: A systematic review and meta-analysis |
| title_short | Relationship between antibiotic exposure and carbapenem-resistant Klebsiella pneumoniae infection within four types of control patients: A systematic review and meta-analysis |
| title_sort | relationship between antibiotic exposure and carbapenem resistant klebsiella pneumoniae infection within four types of control patients a systematic review and meta analysis |
| topic | Carbapenem-resistant Klebsiella pneumonia Antibiotic exposure Risk factor Review and meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2213716523000334 |
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