Mucosa-associated lymphoid tissue lymphoma-induced hemophagocytic lymphohistiocytosis: A case report
Mucosa-associated lymphoid tissue (MALT) lymphoma-induced hemophagocytic lymphohistiocytosis (HLH) has rarely been reported. Herein, we report the diagnosis and treatment process of a patient with MALT lymphoma-induced HLH who received chemotherapy after diagnosis and finally achieved partial remiss...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-10-01
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| Series: | European Journal of Inflammation |
| Online Access: | https://doi.org/10.1177/1721727X221137488 |
| _version_ | 1811257585681039360 |
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| author | Dan Wu Fang Bao Yong Huang |
| author_facet | Dan Wu Fang Bao Yong Huang |
| author_sort | Dan Wu |
| collection | DOAJ |
| description | Mucosa-associated lymphoid tissue (MALT) lymphoma-induced hemophagocytic lymphohistiocytosis (HLH) has rarely been reported. Herein, we report the diagnosis and treatment process of a patient with MALT lymphoma-induced HLH who received chemotherapy after diagnosis and finally achieved partial remission. In this case, blood cells were only reduced to grade II at the time of diagnosis, and the patient was then treated with the R-CHOP regimen (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone). HLH responded well to treatment. Laboratory data indicative of HLH and blood chemistry results were steadily normalized, and hepatosplenomegaly resolved. One month after chemotherapy, the patient achieved partial remission. The results also showed that the treatment was successful. In conclusion, treatment of lymphoma-triggered HLH needs to balance HLH-specific and lymphoma-specific treatment. Once HLH is initially controlled or the decrease in blood cells is better than grade II, it should actively transition to lymphoma treatment. |
| first_indexed | 2024-04-12T17:58:53Z |
| format | Article |
| id | doaj.art-e2150167cb784f888dee9921d6aa7ab6 |
| institution | Directory Open Access Journal |
| issn | 2058-7392 |
| language | English |
| last_indexed | 2024-04-12T17:58:53Z |
| publishDate | 2022-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | European Journal of Inflammation |
| spelling | doaj.art-e2150167cb784f888dee9921d6aa7ab62022-12-22T03:22:14ZengSAGE PublishingEuropean Journal of Inflammation2058-73922022-10-012010.1177/1721727X221137488Mucosa-associated lymphoid tissue lymphoma-induced hemophagocytic lymphohistiocytosis: A case reportDan WuFang BaoYong HuangMucosa-associated lymphoid tissue (MALT) lymphoma-induced hemophagocytic lymphohistiocytosis (HLH) has rarely been reported. Herein, we report the diagnosis and treatment process of a patient with MALT lymphoma-induced HLH who received chemotherapy after diagnosis and finally achieved partial remission. In this case, blood cells were only reduced to grade II at the time of diagnosis, and the patient was then treated with the R-CHOP regimen (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone). HLH responded well to treatment. Laboratory data indicative of HLH and blood chemistry results were steadily normalized, and hepatosplenomegaly resolved. One month after chemotherapy, the patient achieved partial remission. The results also showed that the treatment was successful. In conclusion, treatment of lymphoma-triggered HLH needs to balance HLH-specific and lymphoma-specific treatment. Once HLH is initially controlled or the decrease in blood cells is better than grade II, it should actively transition to lymphoma treatment.https://doi.org/10.1177/1721727X221137488 |
| spellingShingle | Dan Wu Fang Bao Yong Huang Mucosa-associated lymphoid tissue lymphoma-induced hemophagocytic lymphohistiocytosis: A case report European Journal of Inflammation |
| title | Mucosa-associated lymphoid tissue lymphoma-induced hemophagocytic lymphohistiocytosis: A case report |
| title_full | Mucosa-associated lymphoid tissue lymphoma-induced hemophagocytic lymphohistiocytosis: A case report |
| title_fullStr | Mucosa-associated lymphoid tissue lymphoma-induced hemophagocytic lymphohistiocytosis: A case report |
| title_full_unstemmed | Mucosa-associated lymphoid tissue lymphoma-induced hemophagocytic lymphohistiocytosis: A case report |
| title_short | Mucosa-associated lymphoid tissue lymphoma-induced hemophagocytic lymphohistiocytosis: A case report |
| title_sort | mucosa associated lymphoid tissue lymphoma induced hemophagocytic lymphohistiocytosis a case report |
| url | https://doi.org/10.1177/1721727X221137488 |
| work_keys_str_mv | AT danwu mucosaassociatedlymphoidtissuelymphomainducedhemophagocyticlymphohistiocytosisacasereport AT fangbao mucosaassociatedlymphoidtissuelymphomainducedhemophagocyticlymphohistiocytosisacasereport AT yonghuang mucosaassociatedlymphoidtissuelymphomainducedhemophagocyticlymphohistiocytosisacasereport |