Facts and Perspectives: Implications of tumor glycolysis on immunotherapy response in triple negative breast cancer
Triple negative breast cancer (TNBC) is an aggressive disease that is difficult to treat and portends a poor prognosis in many patients. Recent efforts to implement immune checkpoint inhibitors into the treatment landscape of TNBC have led to improved outcomes in a subset of patients both in the ear...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1061789/full |
| _version_ | 1797956411388329984 |
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| author | Ashley Schreier Roberta Zappasodi Roberta Zappasodi Roberta Zappasodi Inna Serganova Inna Serganova Kristy A. Brown Sandra Demaria Eleni Andreopoulou |
| author_facet | Ashley Schreier Roberta Zappasodi Roberta Zappasodi Roberta Zappasodi Inna Serganova Inna Serganova Kristy A. Brown Sandra Demaria Eleni Andreopoulou |
| author_sort | Ashley Schreier |
| collection | DOAJ |
| description | Triple negative breast cancer (TNBC) is an aggressive disease that is difficult to treat and portends a poor prognosis in many patients. Recent efforts to implement immune checkpoint inhibitors into the treatment landscape of TNBC have led to improved outcomes in a subset of patients both in the early stage and metastatic settings. However, a large portion of patients with TNBC remain resistant to immune checkpoint inhibitors and have limited treatment options beyond cytotoxic chemotherapy. The interplay between the anti-tumor immune response and tumor metabolism contributes to immunotherapy response in the preclinical setting, and likely in the clinical setting as well. Specifically, tumor glycolysis and lactate production influence the tumor immune microenvironment through creation of metabolic competition with infiltrating immune cells, which impacts response to immune checkpoint blockade. In this review, we will focus on how glucose metabolism within TNBC tumors influences the response to immune checkpoint blockade and potential ways of harnessing this information to improve clinical outcomes. |
| first_indexed | 2024-04-10T23:48:36Z |
| format | Article |
| id | doaj.art-e216546cd79e4e67a3b6d08b973554a0 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T23:48:36Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-e216546cd79e4e67a3b6d08b973554a02023-01-10T21:49:15ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-01-011210.3389/fonc.2022.10617891061789Facts and Perspectives: Implications of tumor glycolysis on immunotherapy response in triple negative breast cancerAshley Schreier0Roberta Zappasodi1Roberta Zappasodi2Roberta Zappasodi3Inna Serganova4Inna Serganova5Kristy A. Brown6Sandra Demaria7Eleni Andreopoulou8Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York Presbyterian Hospital, New York, NY, United StatesDivision of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, United StatesImmunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, United StatesParker Institute for Cancer Immunotherapy, San Francisco, CA, United StatesDivision of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, United StatesHuman Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, United StatesDepartment of Medicine, Weill Cornell Medicine, New York, NY, United StatesDepartment of Radiation Oncology and Department of Pathology, Weill Cornell Medicine, New York, NY, United StatesDivision of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York Presbyterian Hospital, New York, NY, United StatesTriple negative breast cancer (TNBC) is an aggressive disease that is difficult to treat and portends a poor prognosis in many patients. Recent efforts to implement immune checkpoint inhibitors into the treatment landscape of TNBC have led to improved outcomes in a subset of patients both in the early stage and metastatic settings. However, a large portion of patients with TNBC remain resistant to immune checkpoint inhibitors and have limited treatment options beyond cytotoxic chemotherapy. The interplay between the anti-tumor immune response and tumor metabolism contributes to immunotherapy response in the preclinical setting, and likely in the clinical setting as well. Specifically, tumor glycolysis and lactate production influence the tumor immune microenvironment through creation of metabolic competition with infiltrating immune cells, which impacts response to immune checkpoint blockade. In this review, we will focus on how glucose metabolism within TNBC tumors influences the response to immune checkpoint blockade and potential ways of harnessing this information to improve clinical outcomes.https://www.frontiersin.org/articles/10.3389/fonc.2022.1061789/fulltriple negative breast cancer (TNBC)immune microenviromenttumor glycolysisregulatory T (Treg) cellimmune checkpoint inhibitor (ICI) |
| spellingShingle | Ashley Schreier Roberta Zappasodi Roberta Zappasodi Roberta Zappasodi Inna Serganova Inna Serganova Kristy A. Brown Sandra Demaria Eleni Andreopoulou Facts and Perspectives: Implications of tumor glycolysis on immunotherapy response in triple negative breast cancer Frontiers in Oncology triple negative breast cancer (TNBC) immune microenviroment tumor glycolysis regulatory T (Treg) cell immune checkpoint inhibitor (ICI) |
| title | Facts and Perspectives: Implications of tumor glycolysis on immunotherapy response in triple negative breast cancer |
| title_full | Facts and Perspectives: Implications of tumor glycolysis on immunotherapy response in triple negative breast cancer |
| title_fullStr | Facts and Perspectives: Implications of tumor glycolysis on immunotherapy response in triple negative breast cancer |
| title_full_unstemmed | Facts and Perspectives: Implications of tumor glycolysis on immunotherapy response in triple negative breast cancer |
| title_short | Facts and Perspectives: Implications of tumor glycolysis on immunotherapy response in triple negative breast cancer |
| title_sort | facts and perspectives implications of tumor glycolysis on immunotherapy response in triple negative breast cancer |
| topic | triple negative breast cancer (TNBC) immune microenviroment tumor glycolysis regulatory T (Treg) cell immune checkpoint inhibitor (ICI) |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1061789/full |
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