Tumour Size and T-Stage in Pancreatic Cancer Resection Specimens Depend on the Pathology Examination Approach
In the eighth edition of the TNM classification for pancreatic ductal adenocarcinoma (PDAC), stages T1 to T3 are defined by tumour size, size measurement being deemed objective and accurate. This study investigated whether various, currently used approaches to tumour measurement result in different...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/10/2471 |
| _version_ | 1797501073155424256 |
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| author | My Linh Tran Maia Blomhoff Holm Caroline Sophie Verbeke |
| author_facet | My Linh Tran Maia Blomhoff Holm Caroline Sophie Verbeke |
| author_sort | My Linh Tran |
| collection | DOAJ |
| description | In the eighth edition of the TNM classification for pancreatic ductal adenocarcinoma (PDAC), stages T1 to T3 are defined by tumour size, size measurement being deemed objective and accurate. This study investigated whether various, currently used approaches to tumour measurement result in different tumour sizes and differences in T-stage assignment. In a series of 315 resected PDAC, tumour sizes were measured as follows: macroscopically in a single or in two perpendicular planes and with or without microscopic corroboration. Comparison of the resulting tumour sizes showed that both macroscopic measurement in two planes and microscopic corroboration gave significantly different results (<i>p</i> < 0.001). Compared to the most simple approach (macroscopic measurement in one plane), the comprehensive approach (macroscopic measurement in two planes with microscopic corroboration) resulted in a larger tumour size in 263 (83%) cases (mean absolute size difference: 10 mm; mean relative size change: 36%). T-stage assignment differed in 142 (45%) cases between the simple and comprehensive approach and affected 87%, 38% and 48% of the cases deemed to be stage T1, T2 and T3, respectively. In conclusion, tumour size and T-stage are highly approach-dependent. Consensus on an accurate method is required to ensure comparability of these basic data. |
| first_indexed | 2024-03-10T03:13:05Z |
| format | Article |
| id | doaj.art-e217036834964ec7b5f857dacde246b8 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T03:13:05Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-e217036834964ec7b5f857dacde246b82023-11-23T10:23:40ZengMDPI AGCancers2072-66942022-05-011410247110.3390/cancers14102471Tumour Size and T-Stage in Pancreatic Cancer Resection Specimens Depend on the Pathology Examination ApproachMy Linh Tran0Maia Blomhoff Holm1Caroline Sophie Verbeke2Department of Pathology, Faculty of Medicine, University of Oslo, 0318 Oslo, NorwayDepartment of Pathology, Faculty of Medicine, University of Oslo, 0318 Oslo, NorwayDepartment of Pathology, Faculty of Medicine, University of Oslo, 0318 Oslo, NorwayIn the eighth edition of the TNM classification for pancreatic ductal adenocarcinoma (PDAC), stages T1 to T3 are defined by tumour size, size measurement being deemed objective and accurate. This study investigated whether various, currently used approaches to tumour measurement result in different tumour sizes and differences in T-stage assignment. In a series of 315 resected PDAC, tumour sizes were measured as follows: macroscopically in a single or in two perpendicular planes and with or without microscopic corroboration. Comparison of the resulting tumour sizes showed that both macroscopic measurement in two planes and microscopic corroboration gave significantly different results (<i>p</i> < 0.001). Compared to the most simple approach (macroscopic measurement in one plane), the comprehensive approach (macroscopic measurement in two planes with microscopic corroboration) resulted in a larger tumour size in 263 (83%) cases (mean absolute size difference: 10 mm; mean relative size change: 36%). T-stage assignment differed in 142 (45%) cases between the simple and comprehensive approach and affected 87%, 38% and 48% of the cases deemed to be stage T1, T2 and T3, respectively. In conclusion, tumour size and T-stage are highly approach-dependent. Consensus on an accurate method is required to ensure comparability of these basic data.https://www.mdpi.com/2072-6694/14/10/2471pancreatic cancerpathologytumour sizeT-stage |
| spellingShingle | My Linh Tran Maia Blomhoff Holm Caroline Sophie Verbeke Tumour Size and T-Stage in Pancreatic Cancer Resection Specimens Depend on the Pathology Examination Approach Cancers pancreatic cancer pathology tumour size T-stage |
| title | Tumour Size and T-Stage in Pancreatic Cancer Resection Specimens Depend on the Pathology Examination Approach |
| title_full | Tumour Size and T-Stage in Pancreatic Cancer Resection Specimens Depend on the Pathology Examination Approach |
| title_fullStr | Tumour Size and T-Stage in Pancreatic Cancer Resection Specimens Depend on the Pathology Examination Approach |
| title_full_unstemmed | Tumour Size and T-Stage in Pancreatic Cancer Resection Specimens Depend on the Pathology Examination Approach |
| title_short | Tumour Size and T-Stage in Pancreatic Cancer Resection Specimens Depend on the Pathology Examination Approach |
| title_sort | tumour size and t stage in pancreatic cancer resection specimens depend on the pathology examination approach |
| topic | pancreatic cancer pathology tumour size T-stage |
| url | https://www.mdpi.com/2072-6694/14/10/2471 |
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