Current status and outlook of biodegradable metals in neuroscience and their potential applications as cerebral vascular stent materials
Over the past two decades, biodegradable metals (BMs) have emerged as promising materials to fabricate temporary biomedical devices, with the purpose of avoiding potential side effects of permanent implants. In this review, we first surveyed the current status of BMs in neuroscience, and briefly sum...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2022-05-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X21004436 |
| _version_ | 1797205324587859968 |
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| author | Ming Li Miaowen Jiang Yuan Gao Yufeng Zheng Zhi Liu Chen Zhou Tao Huang Xuenan Gu Ang Li Jiancheng Fang Xunming Ji |
| author_facet | Ming Li Miaowen Jiang Yuan Gao Yufeng Zheng Zhi Liu Chen Zhou Tao Huang Xuenan Gu Ang Li Jiancheng Fang Xunming Ji |
| author_sort | Ming Li |
| collection | DOAJ |
| description | Over the past two decades, biodegradable metals (BMs) have emerged as promising materials to fabricate temporary biomedical devices, with the purpose of avoiding potential side effects of permanent implants. In this review, we first surveyed the current status of BMs in neuroscience, and briefly summarized the representative stents for treating vascular stenosis. Then, inspired by the convincing clinical evidence on the in vivo safety of Mg alloys as cardiovascular stents, we analyzed the possibility of producing biodegradable cerebrovascular Mg alloy stents for treating ischemic stroke. For these novel applications, some key factors should also be considered in designing BM brain stents, including the anatomic features of the cerebral vasculature, hemodynamic influences, neuro-cytocompatibility and selection of alloying elements. This work may provide insights into the future design and fabrication of BM neurological devices, especially for brain stents. |
| first_indexed | 2024-04-24T08:49:19Z |
| format | Article |
| id | doaj.art-e217ac844c354f3aafc8e9870ea8f37a |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:49:19Z |
| publishDate | 2022-05-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-e217ac844c354f3aafc8e9870ea8f37a2024-04-16T12:45:39ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2022-05-0111140153Current status and outlook of biodegradable metals in neuroscience and their potential applications as cerebral vascular stent materialsMing Li0Miaowen Jiang1Yuan Gao2Yufeng Zheng3Zhi Liu4Chen Zhou5Tao Huang6Xuenan Gu7Ang Li8Jiancheng Fang9Xunming Ji10School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing, 100191, China; China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, 100053, ChinaSchool of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing, 100191, ChinaSchool of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing, 100191, ChinaSchool of Materials Science and Engineering, Peking University, Beijing, 100871, China; Corresponding author.Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, ChinaDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China; Department of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, 100053, ChinaDepartment of Biomedical Engineering, University of Melbourne, Parkville, VIC, 3010, AustraliaKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, ChinaDepartment of Biomedical Engineering, Columbia University, New York, NY, 10032, USASchool of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing, 100191, ChinaSchool of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing, 100191, China; China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China; Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China; Department of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China; Corresponding author. School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing, 100191, China.Over the past two decades, biodegradable metals (BMs) have emerged as promising materials to fabricate temporary biomedical devices, with the purpose of avoiding potential side effects of permanent implants. In this review, we first surveyed the current status of BMs in neuroscience, and briefly summarized the representative stents for treating vascular stenosis. Then, inspired by the convincing clinical evidence on the in vivo safety of Mg alloys as cardiovascular stents, we analyzed the possibility of producing biodegradable cerebrovascular Mg alloy stents for treating ischemic stroke. For these novel applications, some key factors should also be considered in designing BM brain stents, including the anatomic features of the cerebral vasculature, hemodynamic influences, neuro-cytocompatibility and selection of alloying elements. This work may provide insights into the future design and fabrication of BM neurological devices, especially for brain stents.http://www.sciencedirect.com/science/article/pii/S2452199X21004436Biodegradable metalsNeuroscienceMg alloysBrain stentsIschemic stroke |
| spellingShingle | Ming Li Miaowen Jiang Yuan Gao Yufeng Zheng Zhi Liu Chen Zhou Tao Huang Xuenan Gu Ang Li Jiancheng Fang Xunming Ji Current status and outlook of biodegradable metals in neuroscience and their potential applications as cerebral vascular stent materials Bioactive Materials Biodegradable metals Neuroscience Mg alloys Brain stents Ischemic stroke |
| title | Current status and outlook of biodegradable metals in neuroscience and their potential applications as cerebral vascular stent materials |
| title_full | Current status and outlook of biodegradable metals in neuroscience and their potential applications as cerebral vascular stent materials |
| title_fullStr | Current status and outlook of biodegradable metals in neuroscience and their potential applications as cerebral vascular stent materials |
| title_full_unstemmed | Current status and outlook of biodegradable metals in neuroscience and their potential applications as cerebral vascular stent materials |
| title_short | Current status and outlook of biodegradable metals in neuroscience and their potential applications as cerebral vascular stent materials |
| title_sort | current status and outlook of biodegradable metals in neuroscience and their potential applications as cerebral vascular stent materials |
| topic | Biodegradable metals Neuroscience Mg alloys Brain stents Ischemic stroke |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X21004436 |
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