Molecular Mechanisms of Ferroptosis and Updates of Ferroptosis Studies in Cancers and Leukemia
Ferroptosis is a mode of cell death regulated by iron-dependent lipid peroxidation. Growing evidence suggests ferroptosis induction as a novel anti-cancer modality that could potentially overcome therapy resistance in cancers. The molecular mechanisms involved in the regulation of ferroptosis are co...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/8/1128 |
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| author | Hiroki Akiyama Bing Z. Carter Michael Andreeff Jo Ishizawa |
| author_facet | Hiroki Akiyama Bing Z. Carter Michael Andreeff Jo Ishizawa |
| author_sort | Hiroki Akiyama |
| collection | DOAJ |
| description | Ferroptosis is a mode of cell death regulated by iron-dependent lipid peroxidation. Growing evidence suggests ferroptosis induction as a novel anti-cancer modality that could potentially overcome therapy resistance in cancers. The molecular mechanisms involved in the regulation of ferroptosis are complex and highly dependent on context. Therefore, a comprehensive understanding of its execution and protection machinery in each tumor type is necessary for the implementation of this unique cell death mode to target individual cancers. Since most of the current evidence for ferroptosis regulation mechanisms is based on solid cancer studies, the knowledge of ferroptosis with regard to leukemia is largely lacking. In this review, we summarize the current understanding of ferroptosis-regulating mechanisms with respect to the metabolism of phospholipids and iron as well as major anti-oxidative pathways that protect cells from ferroptosis. We also highlight the diverse impact of p53, a master regulator of cell death and cellular metabolic processes, on the regulation of ferroptosis. Lastly, we discuss recent ferroptosis studies in leukemia and provide a future perspective for the development of promising anti-leukemia therapies implementing ferroptosis induction. |
| first_indexed | 2024-03-11T05:09:33Z |
| format | Article |
| id | doaj.art-e2188f80db644f0eb389fce5a16e4a50 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T05:09:33Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-e2188f80db644f0eb389fce5a16e4a502023-11-17T18:42:55ZengMDPI AGCells2073-44092023-04-01128112810.3390/cells12081128Molecular Mechanisms of Ferroptosis and Updates of Ferroptosis Studies in Cancers and LeukemiaHiroki Akiyama0Bing Z. Carter1Michael Andreeff2Jo Ishizawa3Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USASection of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USASection of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USASection of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAFerroptosis is a mode of cell death regulated by iron-dependent lipid peroxidation. Growing evidence suggests ferroptosis induction as a novel anti-cancer modality that could potentially overcome therapy resistance in cancers. The molecular mechanisms involved in the regulation of ferroptosis are complex and highly dependent on context. Therefore, a comprehensive understanding of its execution and protection machinery in each tumor type is necessary for the implementation of this unique cell death mode to target individual cancers. Since most of the current evidence for ferroptosis regulation mechanisms is based on solid cancer studies, the knowledge of ferroptosis with regard to leukemia is largely lacking. In this review, we summarize the current understanding of ferroptosis-regulating mechanisms with respect to the metabolism of phospholipids and iron as well as major anti-oxidative pathways that protect cells from ferroptosis. We also highlight the diverse impact of p53, a master regulator of cell death and cellular metabolic processes, on the regulation of ferroptosis. Lastly, we discuss recent ferroptosis studies in leukemia and provide a future perspective for the development of promising anti-leukemia therapies implementing ferroptosis induction.https://www.mdpi.com/2073-4409/12/8/1128ferroptosisleukemiaironphospholipidlipid peroxidationp53 |
| spellingShingle | Hiroki Akiyama Bing Z. Carter Michael Andreeff Jo Ishizawa Molecular Mechanisms of Ferroptosis and Updates of Ferroptosis Studies in Cancers and Leukemia Cells ferroptosis leukemia iron phospholipid lipid peroxidation p53 |
| title | Molecular Mechanisms of Ferroptosis and Updates of Ferroptosis Studies in Cancers and Leukemia |
| title_full | Molecular Mechanisms of Ferroptosis and Updates of Ferroptosis Studies in Cancers and Leukemia |
| title_fullStr | Molecular Mechanisms of Ferroptosis and Updates of Ferroptosis Studies in Cancers and Leukemia |
| title_full_unstemmed | Molecular Mechanisms of Ferroptosis and Updates of Ferroptosis Studies in Cancers and Leukemia |
| title_short | Molecular Mechanisms of Ferroptosis and Updates of Ferroptosis Studies in Cancers and Leukemia |
| title_sort | molecular mechanisms of ferroptosis and updates of ferroptosis studies in cancers and leukemia |
| topic | ferroptosis leukemia iron phospholipid lipid peroxidation p53 |
| url | https://www.mdpi.com/2073-4409/12/8/1128 |
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