MiRNA regulated therapeutic potential of the stromal vascular fraction: Current clinical applications - A systematic review
Introduction: The stromal vascular fraction (SVF) is a heterogeneous population of cells that, interacting with each other, can affect the processes of regeneration, angiogenesis, and immunomodulation. Over the past 20 years, there has been a trend towards an increase in the number of clinical studi...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-06-01
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| Series: | Non-coding RNA Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054022000804 |
| _version_ | 1827267051711889408 |
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| author | Murad Agaverdiev Bedil Shamsov Sorbon Mirzoev Andranik Vardikyan Manuel Encarnacion Ramirez Renat Nurmukhametov Aferin Beilerli Bohan Zhang Ilgiz Gareev Valentin Pavlov |
| author_facet | Murad Agaverdiev Bedil Shamsov Sorbon Mirzoev Andranik Vardikyan Manuel Encarnacion Ramirez Renat Nurmukhametov Aferin Beilerli Bohan Zhang Ilgiz Gareev Valentin Pavlov |
| author_sort | Murad Agaverdiev |
| collection | DOAJ |
| description | Introduction: The stromal vascular fraction (SVF) is a heterogeneous population of cells that, interacting with each other, can affect the processes of regeneration, angiogenesis, and immunomodulation. Over the past 20 years, there has been a trend towards an increase in the number of clinical studies on the therapeutic use of SVF. MicroRNAs (miRNAs) are also important regulators of cellular function and they have been shown to be involved in SVF cellular component function. The purpose of this study was to analyze existing clinical studies on the therapeutic use of SVF including the role of miRNAs in the regulation of the function of the cellular component of SVF as an anti-inflammatory, pro-angiogenic and cell differentiation activity. Methods: The search strategy was to use material from the clinicaltrials.gov website, which focused on the key term ''Stromal vascular fraction'', and the inclusion and exclusion criteria were divided into two stages. Results: By August 2022, there were 149 registered clinical trials. Most studies belong to either Phase 1–2 (49.37%), Phase 1 (25.32%) or Phase 2 (22.78%). Most of them focused in the fields of traumatology, neurology/neurosurgery, endocrinology, vascular surgery, and immunology. However, only 8 clinical trials had published results. All of clinical trials have similar preparation methods and 8 clinical trials have positive results with no serious adverse effects Conclusions: There appears to be a wide potential for the clinical use of SVF without reports of serious side effects. Many preclinical and clinical studies are currently underway on the use of SVF, and their future results will help to further explore their therapeutic potential. Nevertheless, there are not many studies on the role of miRNAs in the SVF microenvironment; however, this topic is very important for further study of the clinical application of SVF, including safety, in various human diseases. |
| first_indexed | 2024-04-09T23:55:13Z |
| format | Article |
| id | doaj.art-e218ac4a41b34dcdad45820ff60f93ab |
| institution | Directory Open Access Journal |
| issn | 2468-0540 |
| language | English |
| last_indexed | 2025-03-22T04:27:36Z |
| publishDate | 2023-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Non-coding RNA Research |
| spelling | doaj.art-e218ac4a41b34dcdad45820ff60f93ab2024-04-28T05:16:01ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402023-06-0182146154MiRNA regulated therapeutic potential of the stromal vascular fraction: Current clinical applications - A systematic reviewMurad Agaverdiev0Bedil Shamsov1Sorbon Mirzoev2Andranik Vardikyan3Manuel Encarnacion Ramirez4Renat Nurmukhametov5Aferin Beilerli6Bohan Zhang7Ilgiz Gareev8Valentin Pavlov9Department of Urology, Bashkir State Medical University, 450008, Ufa, Russian FederationDepartment of Urology, Bashkir State Medical University, 450008, Ufa, Russian FederationDepartment of Urology, City Clinical Hospital, №21, 450071, Ufa, Russian FederationDepartment of Urology, Bashkir State Medical University, 450008, Ufa, Russian FederationDepartment of Neurosurgery, Рeoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow, 117198, Russian FederationDivision of Spine Surgery, Central Clinical Hospital of the Russian Academy of Sciences, Moscow, Russian FederationDepartment of Obstetrics and Gynecology, Tyumen State Medical University, 54 Odesskaya Street, 625023, Tyumen, RussiaDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, No. 23, Youzheng Street, Harbin, 150001, ChinaCentral Research Laboratory, Bashkir State Medical University, 450008, Ufa, Russian Federation; Corresponding author.Department of Urology, Bashkir State Medical University, 450008, Ufa, Russian FederationIntroduction: The stromal vascular fraction (SVF) is a heterogeneous population of cells that, interacting with each other, can affect the processes of regeneration, angiogenesis, and immunomodulation. Over the past 20 years, there has been a trend towards an increase in the number of clinical studies on the therapeutic use of SVF. MicroRNAs (miRNAs) are also important regulators of cellular function and they have been shown to be involved in SVF cellular component function. The purpose of this study was to analyze existing clinical studies on the therapeutic use of SVF including the role of miRNAs in the regulation of the function of the cellular component of SVF as an anti-inflammatory, pro-angiogenic and cell differentiation activity. Methods: The search strategy was to use material from the clinicaltrials.gov website, which focused on the key term ''Stromal vascular fraction'', and the inclusion and exclusion criteria were divided into two stages. Results: By August 2022, there were 149 registered clinical trials. Most studies belong to either Phase 1–2 (49.37%), Phase 1 (25.32%) or Phase 2 (22.78%). Most of them focused in the fields of traumatology, neurology/neurosurgery, endocrinology, vascular surgery, and immunology. However, only 8 clinical trials had published results. All of clinical trials have similar preparation methods and 8 clinical trials have positive results with no serious adverse effects Conclusions: There appears to be a wide potential for the clinical use of SVF without reports of serious side effects. Many preclinical and clinical studies are currently underway on the use of SVF, and their future results will help to further explore their therapeutic potential. Nevertheless, there are not many studies on the role of miRNAs in the SVF microenvironment; however, this topic is very important for further study of the clinical application of SVF, including safety, in various human diseases.http://www.sciencedirect.com/science/article/pii/S2468054022000804miRNAStromal vascular fractionClinical trialTherapyEpidemiology |
| spellingShingle | Murad Agaverdiev Bedil Shamsov Sorbon Mirzoev Andranik Vardikyan Manuel Encarnacion Ramirez Renat Nurmukhametov Aferin Beilerli Bohan Zhang Ilgiz Gareev Valentin Pavlov MiRNA regulated therapeutic potential of the stromal vascular fraction: Current clinical applications - A systematic review Non-coding RNA Research miRNA Stromal vascular fraction Clinical trial Therapy Epidemiology |
| title | MiRNA regulated therapeutic potential of the stromal vascular fraction: Current clinical applications - A systematic review |
| title_full | MiRNA regulated therapeutic potential of the stromal vascular fraction: Current clinical applications - A systematic review |
| title_fullStr | MiRNA regulated therapeutic potential of the stromal vascular fraction: Current clinical applications - A systematic review |
| title_full_unstemmed | MiRNA regulated therapeutic potential of the stromal vascular fraction: Current clinical applications - A systematic review |
| title_short | MiRNA regulated therapeutic potential of the stromal vascular fraction: Current clinical applications - A systematic review |
| title_sort | mirna regulated therapeutic potential of the stromal vascular fraction current clinical applications a systematic review |
| topic | miRNA Stromal vascular fraction Clinical trial Therapy Epidemiology |
| url | http://www.sciencedirect.com/science/article/pii/S2468054022000804 |
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