Role of gut microbiota derived short chain fatty acid metabolites in modulating female reproductive health
Short chain fatty acids (SCFA) have been linked to women's reproductive health, though to a lesser extent, alteration in the production of SCFA and SCFA-producing bacteria has been associated significantly with pregnancy-related complications, unfavourable pregnancy outcomes, menstrual anomalie...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Human Nutrition & Metabolism |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666149724000185 |
| _version_ | 1797259745416970240 |
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| author | Ashwitha Acharya Shilpa S. Shetty Suchetha Kumari N |
| author_facet | Ashwitha Acharya Shilpa S. Shetty Suchetha Kumari N |
| author_sort | Ashwitha Acharya |
| collection | DOAJ |
| description | Short chain fatty acids (SCFA) have been linked to women's reproductive health, though to a lesser extent, alteration in the production of SCFA and SCFA-producing bacteria has been associated significantly with pregnancy-related complications, unfavourable pregnancy outcomes, menstrual anomalies, and gynaecological cancer.The female reproductive system is a delicate, intricate, hormone-dependent group of tissues required for the continuity of life and the species' survival. Reproductive health impacts the ovarian function to implantation and foetal development. Several environmental and physiological factors contribute to mammalian infertility concerns caused by a change in reproductive health status. Several lifestyle factors have been demonstrated to affect reproductive health, including age, body weight, smoking, alcohol consumption, work stress, exercise, diet, and nutrition. Nutrition influences puberty, the menstrual cycle, ovulation, conception, implantation and early foetal development. This review provides an overview of how intestinal derived SCFAs maintains female reproductive health summarizing the current knowledge and future perspectives. Microbial SCFAs improve human metabolism by interfering with, glucose homeostasis, appetite regulation and lipid metabolism. Also affect host immunity and intestinal barrier integrity via primary by inhibition of Histone deacetylases (HDAC) mechanism. Therefore, SCFAs exhibit anti-inflammatory, anti-obesity, immunoregulatory, anti-diabetes, anti-cancer, hepatoprotective, cardiovascular protective and neuroprotective properties.This review highlights recent findings on SCFA and gynaecological pathologies such as preeclampsia, gestational diabetes, pregnancy complications, polycystic ovary syndrome, bacterial vaginosis, and endometriosis to describe current knowledge of the relationship between SCFA and reproductive health and disease in women. |
| first_indexed | 2024-04-24T23:14:19Z |
| format | Article |
| id | doaj.art-e21ada5585de4c07b1e45fff105560c3 |
| institution | Directory Open Access Journal |
| issn | 2666-1497 |
| language | English |
| last_indexed | 2024-04-24T23:14:19Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Human Nutrition & Metabolism |
| spelling | doaj.art-e21ada5585de4c07b1e45fff105560c32024-03-17T07:58:47ZengElsevierHuman Nutrition & Metabolism2666-14972024-06-0136200256Role of gut microbiota derived short chain fatty acid metabolites in modulating female reproductive healthAshwitha Acharya0Shilpa S. Shetty1Suchetha Kumari N2Cellomics, Lipidomics and Molecular Genetics Division, Central Research Laboratory, KS Hegde Medical Academy, Nitte (Deemed to be University), Mangalore, Karnataka, IndiaCellomics, Lipidomics and Molecular Genetics Division, Central Research Laboratory, KS Hegde Medical Academy, Nitte (Deemed to be University), Mangalore, Karnataka, India; Corresponding author. Central Research Laboratory, KS Hegde Medical Academy, Nitte (Deemed to be University), Mangalore, Karnataka, India.Cellomics, Lipidomics and Molecular Genetics Division, Central Research Laboratory, KS Hegde Medical Academy, Nitte (Deemed to be University), Mangalore, Karnataka, India; Department of Biochemistry, KS Hegde Medical Academy, Nitte (Deemed to be University), Mangalore, Karnataka, India; Corresponding author. Department of Biochemistry, KS Hegde Medical Academy, Nitte (Deemed to be University), Mangalore, Karnataka, India.Short chain fatty acids (SCFA) have been linked to women's reproductive health, though to a lesser extent, alteration in the production of SCFA and SCFA-producing bacteria has been associated significantly with pregnancy-related complications, unfavourable pregnancy outcomes, menstrual anomalies, and gynaecological cancer.The female reproductive system is a delicate, intricate, hormone-dependent group of tissues required for the continuity of life and the species' survival. Reproductive health impacts the ovarian function to implantation and foetal development. Several environmental and physiological factors contribute to mammalian infertility concerns caused by a change in reproductive health status. Several lifestyle factors have been demonstrated to affect reproductive health, including age, body weight, smoking, alcohol consumption, work stress, exercise, diet, and nutrition. Nutrition influences puberty, the menstrual cycle, ovulation, conception, implantation and early foetal development. This review provides an overview of how intestinal derived SCFAs maintains female reproductive health summarizing the current knowledge and future perspectives. Microbial SCFAs improve human metabolism by interfering with, glucose homeostasis, appetite regulation and lipid metabolism. Also affect host immunity and intestinal barrier integrity via primary by inhibition of Histone deacetylases (HDAC) mechanism. Therefore, SCFAs exhibit anti-inflammatory, anti-obesity, immunoregulatory, anti-diabetes, anti-cancer, hepatoprotective, cardiovascular protective and neuroprotective properties.This review highlights recent findings on SCFA and gynaecological pathologies such as preeclampsia, gestational diabetes, pregnancy complications, polycystic ovary syndrome, bacterial vaginosis, and endometriosis to describe current knowledge of the relationship between SCFA and reproductive health and disease in women.http://www.sciencedirect.com/science/article/pii/S2666149724000185Short chain fatty acidsGPR41/43Glucagon-like peptide 1Peptide YYGonadotropins |
| spellingShingle | Ashwitha Acharya Shilpa S. Shetty Suchetha Kumari N Role of gut microbiota derived short chain fatty acid metabolites in modulating female reproductive health Human Nutrition & Metabolism Short chain fatty acids GPR41/43 Glucagon-like peptide 1 Peptide YY Gonadotropins |
| title | Role of gut microbiota derived short chain fatty acid metabolites in modulating female reproductive health |
| title_full | Role of gut microbiota derived short chain fatty acid metabolites in modulating female reproductive health |
| title_fullStr | Role of gut microbiota derived short chain fatty acid metabolites in modulating female reproductive health |
| title_full_unstemmed | Role of gut microbiota derived short chain fatty acid metabolites in modulating female reproductive health |
| title_short | Role of gut microbiota derived short chain fatty acid metabolites in modulating female reproductive health |
| title_sort | role of gut microbiota derived short chain fatty acid metabolites in modulating female reproductive health |
| topic | Short chain fatty acids GPR41/43 Glucagon-like peptide 1 Peptide YY Gonadotropins |
| url | http://www.sciencedirect.com/science/article/pii/S2666149724000185 |
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