MAP3K19 regulatory variation in populations with African ancestry may increase COVID-19 severity
Summary: To identify ancestry-linked genetic risk variants associated with COVID-19 hospitalization, we performed an integrative analysis of two genome-wide association studies and resolved four single nucleotide polymorphisms more frequent in COVID-19-hospitalized patients with non-European ancestr...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-09-01
|
| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223016322 |
| _version_ | 1797741024619003904 |
|---|---|
| author | Zhongshan Cheng Yi Cai Ke Zhang Jingxuan Zhang Hongsheng Gui Yu-Si Luo Jie Zhou Brian DeVeale |
| author_facet | Zhongshan Cheng Yi Cai Ke Zhang Jingxuan Zhang Hongsheng Gui Yu-Si Luo Jie Zhou Brian DeVeale |
| author_sort | Zhongshan Cheng |
| collection | DOAJ |
| description | Summary: To identify ancestry-linked genetic risk variants associated with COVID-19 hospitalization, we performed an integrative analysis of two genome-wide association studies and resolved four single nucleotide polymorphisms more frequent in COVID-19-hospitalized patients with non-European ancestry. Among them, the COVID-19 risk SNP rs16831827 shows the largest difference in minor allele frequency (MAF) between populations with African and European ancestry and also shows higher MAF in hospitalized COVID-19 patients among cohorts of mixed ancestry (odds ratio [OR] = 1.20, 95% CI: 1.10–1.30) and entirely African ancestry (OR = 1.30, 95% CI: 1.02–1.67). rs16831827 is an expression quantitative trait locus of MAP3K19. MAP3K19 expression is induced during ciliogenesis and most abundant in ciliated tissues including lungs. Single-cell RNA sequencing analyses revealed that MAP3K19 is highly expressed in multiple ciliated cell types. As rs16831827∗T is associated with reduced MAP3K19 expression, it may increase the risk of severe COVID-19 by reducing MAP3K19 expression. |
| first_indexed | 2024-03-12T14:20:55Z |
| format | Article |
| id | doaj.art-e21ba19c53074d10922fb427beee428f |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-12T14:20:55Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-e21ba19c53074d10922fb427beee428f2023-08-19T04:32:26ZengElsevieriScience2589-00422023-09-01269107555MAP3K19 regulatory variation in populations with African ancestry may increase COVID-19 severityZhongshan Cheng0Yi Cai1Ke Zhang2Jingxuan Zhang3Hongsheng Gui4Yu-Si Luo5Jie Zhou6Brian DeVeale7Center for Applied Bioinformatics, St Jude Children’s Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105, USA; Corresponding authorGuangdong Key Laboratory of Regional Immunity and Diseases, Department of Pathogen Biology, Shenzhen University Medical School, Shenzhen 518000, ChinaThe Key and Characteristic Laboratory of Modern Pathogenicity Biology, School of Basic Medical Sciences, Guizhou Medical University, Guizhou, Guiyang 550025, ChinaHubei Key Laboratory of Embryonic Stem Cell Research, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, Hubei 442000, ChinaBehavioral Health Services and Psychiatry Research, Henry Ford Health, Detroit, MI 48202, USADepartment of Emergency, The Affiliated Hospital of Guizhou Medical University, Guizhou, Guiyang 550004, ChinaDepartment of Microbiology, The University of Hong Kong, Hong Kong 999077, ChinaThe Department of Biomedical Sciences, University of Windsor, Windsor, ON N9B 3P4, Canada; Corresponding authorSummary: To identify ancestry-linked genetic risk variants associated with COVID-19 hospitalization, we performed an integrative analysis of two genome-wide association studies and resolved four single nucleotide polymorphisms more frequent in COVID-19-hospitalized patients with non-European ancestry. Among them, the COVID-19 risk SNP rs16831827 shows the largest difference in minor allele frequency (MAF) between populations with African and European ancestry and also shows higher MAF in hospitalized COVID-19 patients among cohorts of mixed ancestry (odds ratio [OR] = 1.20, 95% CI: 1.10–1.30) and entirely African ancestry (OR = 1.30, 95% CI: 1.02–1.67). rs16831827 is an expression quantitative trait locus of MAP3K19. MAP3K19 expression is induced during ciliogenesis and most abundant in ciliated tissues including lungs. Single-cell RNA sequencing analyses revealed that MAP3K19 is highly expressed in multiple ciliated cell types. As rs16831827∗T is associated with reduced MAP3K19 expression, it may increase the risk of severe COVID-19 by reducing MAP3K19 expression.http://www.sciencedirect.com/science/article/pii/S2589004223016322Health sciencesVirologyHuman Genetics |
| spellingShingle | Zhongshan Cheng Yi Cai Ke Zhang Jingxuan Zhang Hongsheng Gui Yu-Si Luo Jie Zhou Brian DeVeale MAP3K19 regulatory variation in populations with African ancestry may increase COVID-19 severity iScience Health sciences Virology Human Genetics |
| title | MAP3K19 regulatory variation in populations with African ancestry may increase COVID-19 severity |
| title_full | MAP3K19 regulatory variation in populations with African ancestry may increase COVID-19 severity |
| title_fullStr | MAP3K19 regulatory variation in populations with African ancestry may increase COVID-19 severity |
| title_full_unstemmed | MAP3K19 regulatory variation in populations with African ancestry may increase COVID-19 severity |
| title_short | MAP3K19 regulatory variation in populations with African ancestry may increase COVID-19 severity |
| title_sort | map3k19 regulatory variation in populations with african ancestry may increase covid 19 severity |
| topic | Health sciences Virology Human Genetics |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223016322 |
| work_keys_str_mv | AT zhongshancheng map3k19regulatoryvariationinpopulationswithafricanancestrymayincreasecovid19severity AT yicai map3k19regulatoryvariationinpopulationswithafricanancestrymayincreasecovid19severity AT kezhang map3k19regulatoryvariationinpopulationswithafricanancestrymayincreasecovid19severity AT jingxuanzhang map3k19regulatoryvariationinpopulationswithafricanancestrymayincreasecovid19severity AT hongshenggui map3k19regulatoryvariationinpopulationswithafricanancestrymayincreasecovid19severity AT yusiluo map3k19regulatoryvariationinpopulationswithafricanancestrymayincreasecovid19severity AT jiezhou map3k19regulatoryvariationinpopulationswithafricanancestrymayincreasecovid19severity AT briandeveale map3k19regulatoryvariationinpopulationswithafricanancestrymayincreasecovid19severity |