CEACAM1-4L promotes anchorage-independent growth in melanoma
Widespread metastasis is the leading course of death in many types of cancer, including malignant melanoma. The process of metastasis can be divided into a number of complex cell biological events, collectively termed the invasion-metastasis cascade. Previous reports have characterized the capabilit...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-10-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00234/full |
| _version_ | 1811315011021176832 |
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| author | Stefanie eLoeffek Stefanie eLoeffek Nico eUllrich Nico eUllrich André eGörgens Florian eMurke Mara eEilebrecht Mara eEilebrecht Christopher eMenne Christopher eMenne Bernd eGiebel Dirk eSchadendorf Dirk eSchadendorf Bernhard B. Singer Iris eHelfrich Iris eHelfrich |
| author_facet | Stefanie eLoeffek Stefanie eLoeffek Nico eUllrich Nico eUllrich André eGörgens Florian eMurke Mara eEilebrecht Mara eEilebrecht Christopher eMenne Christopher eMenne Bernd eGiebel Dirk eSchadendorf Dirk eSchadendorf Bernhard B. Singer Iris eHelfrich Iris eHelfrich |
| author_sort | Stefanie eLoeffek |
| collection | DOAJ |
| description | Widespread metastasis is the leading course of death in many types of cancer, including malignant melanoma. The process of metastasis can be divided into a number of complex cell biological events, collectively termed the invasion-metastasis cascade. Previous reports have characterized the capability of anchorage-independent growth of cancer cells in vitro as a key characteristic of highly aggressive tumor cells, particularly with respect to metastatic potential. Biological heterogeneity as well as drastic alterations in cell adhesion of disseminated cancer cells support escape mechanisms for metastases to overcome conventional therapies. Here we show that exclusively the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) splice variant CEACAM1-4L supports an anchorage-independent signature in malignant melanoma. These results highlight important variant-specific modulatory functions of CEACAM1 for metastatic spread in patients suffering malignant melanoma. |
| first_indexed | 2024-04-13T11:22:39Z |
| format | Article |
| id | doaj.art-e21dca5cccf445ed853ec25b6ac931fb |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T11:22:39Z |
| publishDate | 2015-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-e21dca5cccf445ed853ec25b6ac931fb2022-12-22T02:48:47ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2015-10-01510.3389/fonc.2015.00234134970CEACAM1-4L promotes anchorage-independent growth in melanomaStefanie eLoeffek0Stefanie eLoeffek1Nico eUllrich2Nico eUllrich3André eGörgens4Florian eMurke5Mara eEilebrecht6Mara eEilebrecht7Christopher eMenne8Christopher eMenne9Bernd eGiebel10Dirk eSchadendorf11Dirk eSchadendorf12Bernhard B. Singer13Iris eHelfrich14Iris eHelfrich15Medical Faculty, University Duisburg-Essen, GermanyGerman Cancer Consortium (DKTK)Medical Faculty, University Duisburg-Essen, GermanyGerman Cancer Consortium (DKTK)Medical Faculty, University Duisburg-EssenMedical Faculty, University Duisburg-EssenMedical Faculty, University Duisburg-Essen, GermanyGerman Cancer Consortium (DKTK)Medical Faculty, University Duisburg-Essen, GermanyGerman Cancer Consortium (DKTK)Medical Faculty, University Duisburg-EssenMedical Faculty, University Duisburg-Essen, GermanyGerman Cancer Consortium (DKTK)University Hospital, University Duisburg-Essen, Essen, GermanyMedical Faculty, University Duisburg-Essen, GermanyGerman Cancer Consortium (DKTK)Widespread metastasis is the leading course of death in many types of cancer, including malignant melanoma. The process of metastasis can be divided into a number of complex cell biological events, collectively termed the invasion-metastasis cascade. Previous reports have characterized the capability of anchorage-independent growth of cancer cells in vitro as a key characteristic of highly aggressive tumor cells, particularly with respect to metastatic potential. Biological heterogeneity as well as drastic alterations in cell adhesion of disseminated cancer cells support escape mechanisms for metastases to overcome conventional therapies. Here we show that exclusively the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) splice variant CEACAM1-4L supports an anchorage-independent signature in malignant melanoma. These results highlight important variant-specific modulatory functions of CEACAM1 for metastatic spread in patients suffering malignant melanoma.http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00234/fullMelanomaCEACAM1metastatic potentialHeterogenityAnchorage-independent cell growth |
| spellingShingle | Stefanie eLoeffek Stefanie eLoeffek Nico eUllrich Nico eUllrich André eGörgens Florian eMurke Mara eEilebrecht Mara eEilebrecht Christopher eMenne Christopher eMenne Bernd eGiebel Dirk eSchadendorf Dirk eSchadendorf Bernhard B. Singer Iris eHelfrich Iris eHelfrich CEACAM1-4L promotes anchorage-independent growth in melanoma Frontiers in Oncology Melanoma CEACAM1 metastatic potential Heterogenity Anchorage-independent cell growth |
| title | CEACAM1-4L promotes anchorage-independent growth in melanoma |
| title_full | CEACAM1-4L promotes anchorage-independent growth in melanoma |
| title_fullStr | CEACAM1-4L promotes anchorage-independent growth in melanoma |
| title_full_unstemmed | CEACAM1-4L promotes anchorage-independent growth in melanoma |
| title_short | CEACAM1-4L promotes anchorage-independent growth in melanoma |
| title_sort | ceacam1 4l promotes anchorage independent growth in melanoma |
| topic | Melanoma CEACAM1 metastatic potential Heterogenity Anchorage-independent cell growth |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00234/full |
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