Predictive Factors of Local Recurrence after Colorectal Cancer Liver Metastases Thermal Ablation
Background: Identify risk factors for local recurrence (LR) after radiofrequency (RFA) and microwave (MWA) thermoablations (TA) of colorectal cancer liver metastases (CCLM). Methods: Uni- (Pearson’s Chi<sup>2</sup> test, Fisher’s exact test, Wilcoxon test) and multivariate analyses (LASS...
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| Format: | Article |
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MDPI AG
2023-03-01
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| Series: | Journal of Imaging |
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| Online Access: | https://www.mdpi.com/2313-433X/9/3/66 |
| _version_ | 1827749396805058560 |
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| author | Julien Odet Julie Pellegrinelli Olivier Varbedian Caroline Truntzer Marco Midulla François Ghiringhelli David Orry |
| author_facet | Julien Odet Julie Pellegrinelli Olivier Varbedian Caroline Truntzer Marco Midulla François Ghiringhelli David Orry |
| author_sort | Julien Odet |
| collection | DOAJ |
| description | Background: Identify risk factors for local recurrence (LR) after radiofrequency (RFA) and microwave (MWA) thermoablations (TA) of colorectal cancer liver metastases (CCLM). Methods: Uni- (Pearson’s Chi<sup>2</sup> test, Fisher’s exact test, Wilcoxon test) and multivariate analyses (LASSO logistic regressions) of every patient treated with MWA or RFA (percutaneously and surgically) from January 2015 to April 2021 in Centre Georges François Leclerc in Dijon, France. Results: Fifty-four patients were treated with TA for 177 CCLM (159 surgically, 18 percutaneously). LR rate was 17.5% of treated lesions. Univariate analyses by lesion showed factors associated with LR: sizes of the lesion (OR = 1.14), size of nearby vessel (OR = 1.27), treatment of a previous TA site LR (OR = 5.03), and non-ovoid TA site shape (OR = 4.25). Multivariate analyses showed that the size of the nearby vessel (OR = 1.17) and the lesion (OR = 1.09) remained significant risk factors of LR. Conclusions: The size of lesions to treat and vessel proximity are LR risk factors that need to be considered when making the decision of thermoablative treatments. TA of an LR on a previous TA site should be reserved to specific situations, as there is an important risk of another LR. An additional TA procedure can be discussed when TA site shape is non-ovoid on control imaging, given the risk of LR. |
| first_indexed | 2024-03-11T06:21:35Z |
| format | Article |
| id | doaj.art-e21e7e41dbc34f4cbffeef850658ff05 |
| institution | Directory Open Access Journal |
| issn | 2313-433X |
| language | English |
| last_indexed | 2024-03-11T06:21:35Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Imaging |
| spelling | doaj.art-e21e7e41dbc34f4cbffeef850658ff052023-11-17T11:55:14ZengMDPI AGJournal of Imaging2313-433X2023-03-01936610.3390/jimaging9030066Predictive Factors of Local Recurrence after Colorectal Cancer Liver Metastases Thermal AblationJulien Odet0Julie Pellegrinelli1Olivier Varbedian2Caroline Truntzer3Marco Midulla4François Ghiringhelli5David Orry6Radiology and Medical Imaging, Dijon Teaching Hospital, 21000 Dijon, FranceRadiology and Medical Imaging, Georges François Leclerc Cancer Center, 21000 Dijon, FranceRadiology and Medical Imaging, Georges François Leclerc Cancer Center, 21000 Dijon, FranceBiostatistics and Bioinformatics, Georges François Leclerc Cancer Center, 21000 Dijon, FranceRadiology and Medical Imaging, Dijon Teaching Hospital, 21000 Dijon, FrancePole of Medical Oncology, Georges François Leclerc Cancer Center, 21000 Dijon, FrancePole of Surgical Oncology, Georges François Leclerc Cancer Center, 21000 Dijon, FranceBackground: Identify risk factors for local recurrence (LR) after radiofrequency (RFA) and microwave (MWA) thermoablations (TA) of colorectal cancer liver metastases (CCLM). Methods: Uni- (Pearson’s Chi<sup>2</sup> test, Fisher’s exact test, Wilcoxon test) and multivariate analyses (LASSO logistic regressions) of every patient treated with MWA or RFA (percutaneously and surgically) from January 2015 to April 2021 in Centre Georges François Leclerc in Dijon, France. Results: Fifty-four patients were treated with TA for 177 CCLM (159 surgically, 18 percutaneously). LR rate was 17.5% of treated lesions. Univariate analyses by lesion showed factors associated with LR: sizes of the lesion (OR = 1.14), size of nearby vessel (OR = 1.27), treatment of a previous TA site LR (OR = 5.03), and non-ovoid TA site shape (OR = 4.25). Multivariate analyses showed that the size of the nearby vessel (OR = 1.17) and the lesion (OR = 1.09) remained significant risk factors of LR. Conclusions: The size of lesions to treat and vessel proximity are LR risk factors that need to be considered when making the decision of thermoablative treatments. TA of an LR on a previous TA site should be reserved to specific situations, as there is an important risk of another LR. An additional TA procedure can be discussed when TA site shape is non-ovoid on control imaging, given the risk of LR.https://www.mdpi.com/2313-433X/9/3/66thermoablationmicrowaveradiofrequencycolorectal cancerliver metastaseslocal recurrence |
| spellingShingle | Julien Odet Julie Pellegrinelli Olivier Varbedian Caroline Truntzer Marco Midulla François Ghiringhelli David Orry Predictive Factors of Local Recurrence after Colorectal Cancer Liver Metastases Thermal Ablation Journal of Imaging thermoablation microwave radiofrequency colorectal cancer liver metastases local recurrence |
| title | Predictive Factors of Local Recurrence after Colorectal Cancer Liver Metastases Thermal Ablation |
| title_full | Predictive Factors of Local Recurrence after Colorectal Cancer Liver Metastases Thermal Ablation |
| title_fullStr | Predictive Factors of Local Recurrence after Colorectal Cancer Liver Metastases Thermal Ablation |
| title_full_unstemmed | Predictive Factors of Local Recurrence after Colorectal Cancer Liver Metastases Thermal Ablation |
| title_short | Predictive Factors of Local Recurrence after Colorectal Cancer Liver Metastases Thermal Ablation |
| title_sort | predictive factors of local recurrence after colorectal cancer liver metastases thermal ablation |
| topic | thermoablation microwave radiofrequency colorectal cancer liver metastases local recurrence |
| url | https://www.mdpi.com/2313-433X/9/3/66 |
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