Interaction of sex and diabetes on the association between hemoglobin glycation index, hemoglobin A1c and serum uric acid
Abstract Background Hemoglobin glycation index (HGI), which is calculated by blood glucose and hemoglobin A1c(HbA1c), reflects the individual discrepancy in HbA1c. This study aimed to investigate the association between HGI/HbA1c and serum uric acid(SUA) stratified by sex and diabetes. Methods The s...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13098-022-00955-1 |
| _version_ | 1811315070137794560 |
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| author | Ying Wei Zhenyu Wu Ying Wang Guang Wang Jia Liu |
| author_facet | Ying Wei Zhenyu Wu Ying Wang Guang Wang Jia Liu |
| author_sort | Ying Wei |
| collection | DOAJ |
| description | Abstract Background Hemoglobin glycation index (HGI), which is calculated by blood glucose and hemoglobin A1c(HbA1c), reflects the individual discrepancy in HbA1c. This study aimed to investigate the association between HGI/HbA1c and serum uric acid(SUA) stratified by sex and diabetes. Methods The study recruited 33772 participants who underwent physical examinations between April 2016 and August 2021 in Beijing Chao-Yang Hospital. A random subsample of 3000 subjects was utilized to calculate the formula of HGI and data of the remaining 30772 participants were used for analysis. HGI and HbA1c were categorized according to quartiles (Q1, Q2, Q3, Q4), using Q1 as the reference. We used multiple linear regression and restricted cubic splines for data analysis. Results 30772 participants with a mean age of 44.4 years old were included in the analysis, 48.6% (N = 14944) of which were female and 7.7% (N = 2363) with diabetes. Associations of HGI, HbA1c and SUA were modified by sex and diabetes. The relationship between SUA levels and HGI was positive in women without diabetes, with one unit increase in HGI associating with an 11.3 μmol/L increase in SUA (P < 0.001) after adjusting for other confounders. On average, each one-unit increase in HbA1c was associated with a 14.3 μmol/L decrease in SUA in women with diabetes, a 14.9 μmol/L decrease in SUA in men with diabetes, and a 16.5 μmol/L increase in SUA in women without diabetes (all P < 0.001). The SUA levels in men without diabetes showed a bell-shaped relation with HbA1c, increasing as the HbA1c rose to around 5.7% and then falling with a further increase of HbA1c (P < 0.001). Conclusions SUA levels were inversely correlated with HbA1c in diabetic patients, also in men with prediabetes (HbA1c ≥ 5.7%), but positively correlated with HbA1c and HGI in women without diabetes. Glycemic control may help to reduce the risk of hyperuricemia in non-diabetes women. |
| first_indexed | 2024-04-13T11:23:43Z |
| format | Article |
| id | doaj.art-e21e845beba048d692e685fbb09ff07c |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-04-13T11:23:43Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-e21e845beba048d692e685fbb09ff07c2022-12-22T02:48:46ZengBMCDiabetology & Metabolic Syndrome1758-59962022-12-0114111110.1186/s13098-022-00955-1Interaction of sex and diabetes on the association between hemoglobin glycation index, hemoglobin A1c and serum uric acidYing Wei0Zhenyu Wu1Ying Wang2Guang Wang3Jia Liu4Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical UniversityDepartment of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical UniversityHealth Management Center, Beijing Chao-Yang Hospital, Capital Medical UniversityDepartment of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical UniversityDepartment of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical UniversityAbstract Background Hemoglobin glycation index (HGI), which is calculated by blood glucose and hemoglobin A1c(HbA1c), reflects the individual discrepancy in HbA1c. This study aimed to investigate the association between HGI/HbA1c and serum uric acid(SUA) stratified by sex and diabetes. Methods The study recruited 33772 participants who underwent physical examinations between April 2016 and August 2021 in Beijing Chao-Yang Hospital. A random subsample of 3000 subjects was utilized to calculate the formula of HGI and data of the remaining 30772 participants were used for analysis. HGI and HbA1c were categorized according to quartiles (Q1, Q2, Q3, Q4), using Q1 as the reference. We used multiple linear regression and restricted cubic splines for data analysis. Results 30772 participants with a mean age of 44.4 years old were included in the analysis, 48.6% (N = 14944) of which were female and 7.7% (N = 2363) with diabetes. Associations of HGI, HbA1c and SUA were modified by sex and diabetes. The relationship between SUA levels and HGI was positive in women without diabetes, with one unit increase in HGI associating with an 11.3 μmol/L increase in SUA (P < 0.001) after adjusting for other confounders. On average, each one-unit increase in HbA1c was associated with a 14.3 μmol/L decrease in SUA in women with diabetes, a 14.9 μmol/L decrease in SUA in men with diabetes, and a 16.5 μmol/L increase in SUA in women without diabetes (all P < 0.001). The SUA levels in men without diabetes showed a bell-shaped relation with HbA1c, increasing as the HbA1c rose to around 5.7% and then falling with a further increase of HbA1c (P < 0.001). Conclusions SUA levels were inversely correlated with HbA1c in diabetic patients, also in men with prediabetes (HbA1c ≥ 5.7%), but positively correlated with HbA1c and HGI in women without diabetes. Glycemic control may help to reduce the risk of hyperuricemia in non-diabetes women.https://doi.org/10.1186/s13098-022-00955-1Hemoglobin glycation indexGlycated hemoglobin AUric acidSexDiabetes mellitus |
| spellingShingle | Ying Wei Zhenyu Wu Ying Wang Guang Wang Jia Liu Interaction of sex and diabetes on the association between hemoglobin glycation index, hemoglobin A1c and serum uric acid Diabetology & Metabolic Syndrome Hemoglobin glycation index Glycated hemoglobin A Uric acid Sex Diabetes mellitus |
| title | Interaction of sex and diabetes on the association between hemoglobin glycation index, hemoglobin A1c and serum uric acid |
| title_full | Interaction of sex and diabetes on the association between hemoglobin glycation index, hemoglobin A1c and serum uric acid |
| title_fullStr | Interaction of sex and diabetes on the association between hemoglobin glycation index, hemoglobin A1c and serum uric acid |
| title_full_unstemmed | Interaction of sex and diabetes on the association between hemoglobin glycation index, hemoglobin A1c and serum uric acid |
| title_short | Interaction of sex and diabetes on the association between hemoglobin glycation index, hemoglobin A1c and serum uric acid |
| title_sort | interaction of sex and diabetes on the association between hemoglobin glycation index hemoglobin a1c and serum uric acid |
| topic | Hemoglobin glycation index Glycated hemoglobin A Uric acid Sex Diabetes mellitus |
| url | https://doi.org/10.1186/s13098-022-00955-1 |
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