α-GalCer and iNKT Cell-Based Cancer Immunotherapy: Realizing the Therapeutic Potentials

α-GalCer and iNKT Cell-Based Cancer Immunotherapy: Realizing the Therapeutic Potentials

NKT cells are CD1d-restricted innate-like T cells expressing both T cell receptor and NK cell markers. The major group of NKT cells in both human and mice is the invariant NKT (iNKT) cells and the best-known function of iNKT cells is their potent anti-tumor function in mice. Since its discovery 25 y...

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Bibliographic Details
Main Authors: Yingting Zhang, Ryan Springfield, Siyang Chen, Xin Li, Xiaotian Feng, Rosa Moshirian, Rirong Yang, Weiming Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
iNKT cell
cancer immonotherapy
preclinical modeling
humanized mice
α-GalCer
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01126/full

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