Distinct Mitochondrial Remodeling During Mesoderm Differentiation in a Human-Based Stem Cell Model

Distinct Mitochondrial Remodeling During Mesoderm Differentiation in a Human-Based Stem Cell Model

Given the considerable interest in using stem cells for modeling and treating disease, it is essential to understand what regulates self-renewal and differentiation. Remodeling of mitochondria and metabolism, with the shift from glycolysis to oxidative phosphorylation (OXPHOS), plays a fundamental r...

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Bibliographic Details
Main Authors: Sepideh Mostafavi, Novin Balafkan, Ina Katrine Nitschke Pettersen, Gonzalo S. Nido, Richard Siller, Charalampos Tzoulis, Gareth J. Sullivan, Laurence A. Bindoff
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
mitochondria
development
metabolism
stem cells
cardiomyocyte
OXPHOS
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.744777/full

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