Accuracy Rate of Methylene Blue Injection in Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer Patients: A Prospective Observational Study
Harlan Kasyfil Aziz,1 Yohana Azhar,2 Irra Rubianti Widarda,2 Maman Abdurahman,2 Zuldi Erdiansyah,1 Prapanca Nugraha,1 Kiki Lukman1 1Department of Surgery, Faculty of Medicine, University of Padjadjaran, Bandung, West Java, Indonesia; 2Department of Surgery, Dr. Hasan Sadikin General Hospital, Bandun...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-12-01
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| Series: | Breast Cancer: Targets and Therapy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/accuracy-rate-of-methylene-blue-injection-in-sentinel-lymph-node-biops-peer-reviewed-fulltext-article-BCTT |
| _version_ | 1797401180325806080 |
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| author | Aziz HK Azhar Y Widarda IR Abdurahman M Erdiansyah Z Nugraha P Lukman K |
| author_facet | Aziz HK Azhar Y Widarda IR Abdurahman M Erdiansyah Z Nugraha P Lukman K |
| author_sort | Aziz HK |
| collection | DOAJ |
| description | Harlan Kasyfil Aziz,1 Yohana Azhar,2 Irra Rubianti Widarda,2 Maman Abdurahman,2 Zuldi Erdiansyah,1 Prapanca Nugraha,1 Kiki Lukman1 1Department of Surgery, Faculty of Medicine, University of Padjadjaran, Bandung, West Java, Indonesia; 2Department of Surgery, Dr. Hasan Sadikin General Hospital, Bandung, West Java, IndonesiaCorrespondence: Kiki Lukman; Yohana Azhar, Email kiki.lukman@unpad.ac.id; r.yohana@unpad.ac.idObjective: Breast cancer is the most prevalent cancer in women and can spread to the lymph nodes in the axilla. The sentinel lymph node is the first lymph node to be targeted for the spread or metastasis of cancer cells involving the lymph nodes. The aim of this study is to compare the accuracy rate of methylene blue injection into sentinel lymph nodes in early-stage breast cancer patients who have undergone incisional and excisional biopsies.Methods: This is a prospective observational study conducted in two general hospitals in West Java, Indonesia. The research subjects in this study were early-stage breast cancer patients with no lymph node metastasis (N0) who had undergone a biopsy. There were 83 study subjects included in this study. The sentinel lymph node biopsy was taken after injection of methylene blue into the peritumoral area. Blue nodes in the axilla were marked as positive lymph node biopsy results and sent for histopathology examination.Results: Patients who underwent excisional biopsy surgery had a sensitivity rate of 85.3% and a specificity of 93.3%, while the accuracy rate in patients who underwent incisional biopsy surgery had a sensitivity rate of 79.2% and a specificity of 80%.Conclusion: There was no difference in the accuracy of SLNB using methylene blue in patients with early-stage breast cancer with N0 who had a history of incisional and excisional biopsy.Keywords: biopsy, breast cancer, methylene blue, sentinel lymph nodes |
| first_indexed | 2024-03-09T02:06:09Z |
| format | Article |
| id | doaj.art-e222c136367649188820fa22f71c75dd |
| institution | Directory Open Access Journal |
| issn | 1179-1314 |
| language | English |
| last_indexed | 2024-03-09T02:06:09Z |
| publishDate | 2023-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Breast Cancer: Targets and Therapy |
| spelling | doaj.art-e222c136367649188820fa22f71c75dd2023-12-07T18:03:42ZengDove Medical PressBreast Cancer: Targets and Therapy1179-13142023-12-01Volume 1589189788832Accuracy Rate of Methylene Blue Injection in Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer Patients: A Prospective Observational StudyAziz HKAzhar YWidarda IRAbdurahman MErdiansyah ZNugraha PLukman KHarlan Kasyfil Aziz,1 Yohana Azhar,2 Irra Rubianti Widarda,2 Maman Abdurahman,2 Zuldi Erdiansyah,1 Prapanca Nugraha,1 Kiki Lukman1 1Department of Surgery, Faculty of Medicine, University of Padjadjaran, Bandung, West Java, Indonesia; 2Department of Surgery, Dr. Hasan Sadikin General Hospital, Bandung, West Java, IndonesiaCorrespondence: Kiki Lukman; Yohana Azhar, Email kiki.lukman@unpad.ac.id; r.yohana@unpad.ac.idObjective: Breast cancer is the most prevalent cancer in women and can spread to the lymph nodes in the axilla. The sentinel lymph node is the first lymph node to be targeted for the spread or metastasis of cancer cells involving the lymph nodes. The aim of this study is to compare the accuracy rate of methylene blue injection into sentinel lymph nodes in early-stage breast cancer patients who have undergone incisional and excisional biopsies.Methods: This is a prospective observational study conducted in two general hospitals in West Java, Indonesia. The research subjects in this study were early-stage breast cancer patients with no lymph node metastasis (N0) who had undergone a biopsy. There were 83 study subjects included in this study. The sentinel lymph node biopsy was taken after injection of methylene blue into the peritumoral area. Blue nodes in the axilla were marked as positive lymph node biopsy results and sent for histopathology examination.Results: Patients who underwent excisional biopsy surgery had a sensitivity rate of 85.3% and a specificity of 93.3%, while the accuracy rate in patients who underwent incisional biopsy surgery had a sensitivity rate of 79.2% and a specificity of 80%.Conclusion: There was no difference in the accuracy of SLNB using methylene blue in patients with early-stage breast cancer with N0 who had a history of incisional and excisional biopsy.Keywords: biopsy, breast cancer, methylene blue, sentinel lymph nodeshttps://www.dovepress.com/accuracy-rate-of-methylene-blue-injection-in-sentinel-lymph-node-biops-peer-reviewed-fulltext-article-BCTTbiopsybreast cancermethylene bluesentinel lymph nodes |
| spellingShingle | Aziz HK Azhar Y Widarda IR Abdurahman M Erdiansyah Z Nugraha P Lukman K Accuracy Rate of Methylene Blue Injection in Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer Patients: A Prospective Observational Study Breast Cancer: Targets and Therapy biopsy breast cancer methylene blue sentinel lymph nodes |
| title | Accuracy Rate of Methylene Blue Injection in Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer Patients: A Prospective Observational Study |
| title_full | Accuracy Rate of Methylene Blue Injection in Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer Patients: A Prospective Observational Study |
| title_fullStr | Accuracy Rate of Methylene Blue Injection in Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer Patients: A Prospective Observational Study |
| title_full_unstemmed | Accuracy Rate of Methylene Blue Injection in Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer Patients: A Prospective Observational Study |
| title_short | Accuracy Rate of Methylene Blue Injection in Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer Patients: A Prospective Observational Study |
| title_sort | accuracy rate of methylene blue injection in sentinel lymph node biopsy in early stage breast cancer patients a prospective observational study |
| topic | biopsy breast cancer methylene blue sentinel lymph nodes |
| url | https://www.dovepress.com/accuracy-rate-of-methylene-blue-injection-in-sentinel-lymph-node-biops-peer-reviewed-fulltext-article-BCTT |
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