Pneumatosis cystoides intestinalis associated with etoposide in hematological malignancies: a case report and a literature review
Abstract Pneumatosis cystoides intestinalis (PCI) is a rare condition characterized by the presence of air collection within the subserosa and/or submucosa of the gastrointestinal wall. Due to the lack of specific symptoms, PCI is likely to be misdiagnosed or missed without the use of imaging techni...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-03-01
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| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12876-022-02219-8 |
| _version_ | 1818645299975946240 |
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| author | Liqing Yang Xi Zhong Hao Yang Qin Wu Yuping Gong Bo Wang |
| author_facet | Liqing Yang Xi Zhong Hao Yang Qin Wu Yuping Gong Bo Wang |
| author_sort | Liqing Yang |
| collection | DOAJ |
| description | Abstract Pneumatosis cystoides intestinalis (PCI) is a rare condition characterized by the presence of air collection within the subserosa and/or submucosa of the gastrointestinal wall. Due to the lack of specific symptoms, PCI is likely to be misdiagnosed or missed without the use of imaging techniques or gastrointestinal endoscopy. Here, we report a patient who complained of abdominal distention and constipation after chemotherapy for hematological malignancies, and was diagnosed with secondary PCI via computed tomography (CT) and exploratory laparotomy. Pneumoperitoneum was no longer observed after two weeks of conservative treatments. Notably, the possibility of intra-abdominal pressure (IAP) as a predictor for surgical intervention was proposed. Furthermore, we conducted a literature review on PCI after chemotherapy in hematological malignancies to raise awareness of etoposide-related PCI, while whether PCI could be identified as an adverse event of etoposide requires more evidence. |
| first_indexed | 2024-12-17T00:28:33Z |
| format | Article |
| id | doaj.art-e22338eb88af4eca9d1a664082e58d0d |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-17T00:28:33Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-e22338eb88af4eca9d1a664082e58d0d2022-12-21T22:10:24ZengBMCBMC Gastroenterology1471-230X2022-03-012211910.1186/s12876-022-02219-8Pneumatosis cystoides intestinalis associated with etoposide in hematological malignancies: a case report and a literature reviewLiqing Yang0Xi Zhong1Hao Yang2Qin Wu3Yuping Gong4Bo Wang5Department of Hematology, West China Hospital, Sichuan UniversityDepartment of Critical Care Medicine, West China Hospital, Sichuan UniversityDepartment of Critical Care Medicine, West China Hospital, Sichuan UniversityDepartment of Critical Care Medicine, West China Hospital, Sichuan UniversityDepartment of Hematology, West China Hospital, Sichuan UniversityDepartment of Critical Care Medicine, West China Hospital, Sichuan UniversityAbstract Pneumatosis cystoides intestinalis (PCI) is a rare condition characterized by the presence of air collection within the subserosa and/or submucosa of the gastrointestinal wall. Due to the lack of specific symptoms, PCI is likely to be misdiagnosed or missed without the use of imaging techniques or gastrointestinal endoscopy. Here, we report a patient who complained of abdominal distention and constipation after chemotherapy for hematological malignancies, and was diagnosed with secondary PCI via computed tomography (CT) and exploratory laparotomy. Pneumoperitoneum was no longer observed after two weeks of conservative treatments. Notably, the possibility of intra-abdominal pressure (IAP) as a predictor for surgical intervention was proposed. Furthermore, we conducted a literature review on PCI after chemotherapy in hematological malignancies to raise awareness of etoposide-related PCI, while whether PCI could be identified as an adverse event of etoposide requires more evidence.https://doi.org/10.1186/s12876-022-02219-8Pneumatosis cystoides intestinalisPneumoperitoneumIntra-abdominal pressureEtoposideHematological malignancy |
| spellingShingle | Liqing Yang Xi Zhong Hao Yang Qin Wu Yuping Gong Bo Wang Pneumatosis cystoides intestinalis associated with etoposide in hematological malignancies: a case report and a literature review BMC Gastroenterology Pneumatosis cystoides intestinalis Pneumoperitoneum Intra-abdominal pressure Etoposide Hematological malignancy |
| title | Pneumatosis cystoides intestinalis associated with etoposide in hematological malignancies: a case report and a literature review |
| title_full | Pneumatosis cystoides intestinalis associated with etoposide in hematological malignancies: a case report and a literature review |
| title_fullStr | Pneumatosis cystoides intestinalis associated with etoposide in hematological malignancies: a case report and a literature review |
| title_full_unstemmed | Pneumatosis cystoides intestinalis associated with etoposide in hematological malignancies: a case report and a literature review |
| title_short | Pneumatosis cystoides intestinalis associated with etoposide in hematological malignancies: a case report and a literature review |
| title_sort | pneumatosis cystoides intestinalis associated with etoposide in hematological malignancies a case report and a literature review |
| topic | Pneumatosis cystoides intestinalis Pneumoperitoneum Intra-abdominal pressure Etoposide Hematological malignancy |
| url | https://doi.org/10.1186/s12876-022-02219-8 |
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