Cellular landscaping of exosomal miRNAs in cancer metastasis: From chemoresistance to prognostic markers
Exosomes are cargos facilitating the transport of miRNAs across cancer cells. Exosomal miRNA has been an area of interest in recent times due to their triple role in cancer proliferation. The current review discusses the triple role of exosomal miRNAs and proposes its application in diagnosis as a p...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Advances in Cancer Biology - Metastasis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667394022000247 |
| _version_ | 1818049599290474496 |
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| author | Rahul Bhattacharjee Priya Mitra Nitin Gupta Sony Sharma Vipendra Kumar Singh Nobendu Mukerjee Archna Dhasmana Rohit Gundamaraju |
| author_facet | Rahul Bhattacharjee Priya Mitra Nitin Gupta Sony Sharma Vipendra Kumar Singh Nobendu Mukerjee Archna Dhasmana Rohit Gundamaraju |
| author_sort | Rahul Bhattacharjee |
| collection | DOAJ |
| description | Exosomes are cargos facilitating the transport of miRNAs across cancer cells. Exosomal miRNA has been an area of interest in recent times due to their triple role in cancer proliferation. The current review discusses the triple role of exosomal miRNAs and proposes its application in diagnosis as a prognostic marker. Exosomal miRNAs are miRNAs found inside the exosomal structure of 30–150 nm of an extracellular vesicle. The synthesis and biogenesis of these exosomal miRNA involve an endosomal sorting complex required for transport which releases miRNAs and relevant proteins to cause tumor heterogeneity, drug resistance, and cancer metastasis. Herein, we have highlighted the role of exosomal miRNAs in both drug resistance and cancer metastasis. Additionally, we have elucidated the impact of exosomal miRNAs upon host immunity, which will provide us with the idea of host immune rejection. Furthermore, we have elaborated the clinical importance of exosomal miRNAs as a prognostic marker. |
| first_indexed | 2024-12-10T10:40:08Z |
| format | Article |
| id | doaj.art-e22422d32529434aba21c2cdf940b417 |
| institution | Directory Open Access Journal |
| issn | 2667-3940 |
| language | English |
| last_indexed | 2024-12-10T10:40:08Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Cancer Biology - Metastasis |
| spelling | doaj.art-e22422d32529434aba21c2cdf940b4172022-12-22T01:52:20ZengElsevierAdvances in Cancer Biology - Metastasis2667-39402022-10-015100050Cellular landscaping of exosomal miRNAs in cancer metastasis: From chemoresistance to prognostic markersRahul Bhattacharjee0Priya Mitra1Nitin Gupta2Sony Sharma3Vipendra Kumar Singh4Nobendu Mukerjee5Archna Dhasmana6Rohit Gundamaraju7Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, IsraelKIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar, 751024, Odisha, IndiaCentre of Biomedical Research, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226014, (U.P), IndiaDepartment of Neurovirology, National Institute of Mental Health and Neuroscience, Bengaluru, Karnataka, 560029, IndiaSchool of Basic Sciences, Indian Institute of Technology Mandi, Himachal Pradesh, 175005, IndiaDepartment of Microbiology, Ramakrishna Mission Vivekananda Centenary College, West Bengal, 700118, Kolkata, India; Department of Health Sciences, Novel Global Community Educational Foundation, AustraliaHimalayan School of Biosciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, 248016, IndiaER Stress and Mucosal Immunology Lab, School of Health Sciences, University of Tasmania, Launceston, Tasmania, 7248, Australia; Corresponding author.Exosomes are cargos facilitating the transport of miRNAs across cancer cells. Exosomal miRNA has been an area of interest in recent times due to their triple role in cancer proliferation. The current review discusses the triple role of exosomal miRNAs and proposes its application in diagnosis as a prognostic marker. Exosomal miRNAs are miRNAs found inside the exosomal structure of 30–150 nm of an extracellular vesicle. The synthesis and biogenesis of these exosomal miRNA involve an endosomal sorting complex required for transport which releases miRNAs and relevant proteins to cause tumor heterogeneity, drug resistance, and cancer metastasis. Herein, we have highlighted the role of exosomal miRNAs in both drug resistance and cancer metastasis. Additionally, we have elucidated the impact of exosomal miRNAs upon host immunity, which will provide us with the idea of host immune rejection. Furthermore, we have elaborated the clinical importance of exosomal miRNAs as a prognostic marker.http://www.sciencedirect.com/science/article/pii/S2667394022000247miRNAsMetastasisChemoresistancePrognosisExtracellular vesiclesImmunotherapy |
| spellingShingle | Rahul Bhattacharjee Priya Mitra Nitin Gupta Sony Sharma Vipendra Kumar Singh Nobendu Mukerjee Archna Dhasmana Rohit Gundamaraju Cellular landscaping of exosomal miRNAs in cancer metastasis: From chemoresistance to prognostic markers Advances in Cancer Biology - Metastasis miRNAs Metastasis Chemoresistance Prognosis Extracellular vesicles Immunotherapy |
| title | Cellular landscaping of exosomal miRNAs in cancer metastasis: From chemoresistance to prognostic markers |
| title_full | Cellular landscaping of exosomal miRNAs in cancer metastasis: From chemoresistance to prognostic markers |
| title_fullStr | Cellular landscaping of exosomal miRNAs in cancer metastasis: From chemoresistance to prognostic markers |
| title_full_unstemmed | Cellular landscaping of exosomal miRNAs in cancer metastasis: From chemoresistance to prognostic markers |
| title_short | Cellular landscaping of exosomal miRNAs in cancer metastasis: From chemoresistance to prognostic markers |
| title_sort | cellular landscaping of exosomal mirnas in cancer metastasis from chemoresistance to prognostic markers |
| topic | miRNAs Metastasis Chemoresistance Prognosis Extracellular vesicles Immunotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S2667394022000247 |
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