Evaluation of Anti-Convulsive Properties of Aqueous Kava Extract on Zebrafish Using the PTZ-Induced Seizure Model
Kava roots have been extensively studied in clinical trials as potential candidate anti-anxiety drugs. However, anti-convulsive properties of various tissues of stems of Kava have not been reported to date. The objective of the study was to evaluate the anti-convulsive potential of aqueous extracts...
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MDPI AG
2020-08-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/10/8/541 |
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| author | Yogini Jaiswal Mohd. Farooq Shaikh Ilya Wang Yanning Yong Vanessa Lin Lin Lee Leonard Williams |
| author_facet | Yogini Jaiswal Mohd. Farooq Shaikh Ilya Wang Yanning Yong Vanessa Lin Lin Lee Leonard Williams |
| author_sort | Yogini Jaiswal |
| collection | DOAJ |
| description | Kava roots have been extensively studied in clinical trials as potential candidate anti-anxiety drugs. However, anti-convulsive properties of various tissues of stems of Kava have not been reported to date. The objective of the study was to evaluate the anti-convulsive potential of aqueous extracts prepared from specific tissues of Kava (<i>Piper methysticum</i>) stems in zebrafish, using the PTZ-induced seizure model. The potency of each extract was compared in terms of the intensity of seizure scores and onset time after pre-treating the zebrafish before the PTZ challenge. The results indicate that aqueous extract of Kava stems without peel after 45 min of pre-treatment exhibited anti-convulsive potential at the dose of 50 mg/L. This study provides evidence to the anti-convulsive properties of peeled Kava stems and its potential for investigation and design of candidate anti-convulsive drugs. |
| first_indexed | 2024-03-10T17:39:08Z |
| format | Article |
| id | doaj.art-e22655b37be843aeb70b4659b9abfff5 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T17:39:08Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-e22655b37be843aeb70b4659b9abfff52023-11-20T09:45:48ZengMDPI AGBrain Sciences2076-34252020-08-0110854110.3390/brainsci10080541Evaluation of Anti-Convulsive Properties of Aqueous Kava Extract on Zebrafish Using the PTZ-Induced Seizure ModelYogini Jaiswal0Mohd. Farooq Shaikh1Ilya Wang2Yanning Yong3Vanessa Lin Lin Lee4Leonard Williams5Center for Excellence in Post-Harvest Technologies, The North Carolina Research Campus, 500 Laureate Way, Kannapolis, NC 28081, USANeuropharmacology Research Laboratory, Jeffrey Cheah School of Medicine & Health Sciences, Monash University Malaysia, Bandar Sunway 47500, MalaysiaBeaver College of Health Sciences, Appalachian State University, 287 Rivers Street, Boone, NC 28608, USANeuropharmacology Research Laboratory, Jeffrey Cheah School of Medicine & Health Sciences, Monash University Malaysia, Bandar Sunway 47500, MalaysiaNeuropharmacology Research Laboratory, Jeffrey Cheah School of Medicine & Health Sciences, Monash University Malaysia, Bandar Sunway 47500, MalaysiaCenter for Excellence in Post-Harvest Technologies, The North Carolina Research Campus, 500 Laureate Way, Kannapolis, NC 28081, USAKava roots have been extensively studied in clinical trials as potential candidate anti-anxiety drugs. However, anti-convulsive properties of various tissues of stems of Kava have not been reported to date. The objective of the study was to evaluate the anti-convulsive potential of aqueous extracts prepared from specific tissues of Kava (<i>Piper methysticum</i>) stems in zebrafish, using the PTZ-induced seizure model. The potency of each extract was compared in terms of the intensity of seizure scores and onset time after pre-treating the zebrafish before the PTZ challenge. The results indicate that aqueous extract of Kava stems without peel after 45 min of pre-treatment exhibited anti-convulsive potential at the dose of 50 mg/L. This study provides evidence to the anti-convulsive properties of peeled Kava stems and its potential for investigation and design of candidate anti-convulsive drugs.https://www.mdpi.com/2076-3425/10/8/541Kava (<i>Piper methysticum</i>)anti-convulsive activityPTZ-induced seizure modelzebrafish |
| spellingShingle | Yogini Jaiswal Mohd. Farooq Shaikh Ilya Wang Yanning Yong Vanessa Lin Lin Lee Leonard Williams Evaluation of Anti-Convulsive Properties of Aqueous Kava Extract on Zebrafish Using the PTZ-Induced Seizure Model Brain Sciences Kava (<i>Piper methysticum</i>) anti-convulsive activity PTZ-induced seizure model zebrafish |
| title | Evaluation of Anti-Convulsive Properties of Aqueous Kava Extract on Zebrafish Using the PTZ-Induced Seizure Model |
| title_full | Evaluation of Anti-Convulsive Properties of Aqueous Kava Extract on Zebrafish Using the PTZ-Induced Seizure Model |
| title_fullStr | Evaluation of Anti-Convulsive Properties of Aqueous Kava Extract on Zebrafish Using the PTZ-Induced Seizure Model |
| title_full_unstemmed | Evaluation of Anti-Convulsive Properties of Aqueous Kava Extract on Zebrafish Using the PTZ-Induced Seizure Model |
| title_short | Evaluation of Anti-Convulsive Properties of Aqueous Kava Extract on Zebrafish Using the PTZ-Induced Seizure Model |
| title_sort | evaluation of anti convulsive properties of aqueous kava extract on zebrafish using the ptz induced seizure model |
| topic | Kava (<i>Piper methysticum</i>) anti-convulsive activity PTZ-induced seizure model zebrafish |
| url | https://www.mdpi.com/2076-3425/10/8/541 |
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