Identifying transdiagnostic biological subtypes across schizophrenia, bipolar disorder, and major depressive disorder based on lipidomics profiles
Emerging evidence has demonstrated overlapping biological abnormalities underlying schizophrenia (SCZ), bipolar disorder (BP), and major depressive disorder (MDD); these overlapping abnormalities help explain the high heterogeneity and the similarity of patients within and among diagnostic categorie...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-09-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.969575/full |
| _version_ | 1798004538459815936 |
|---|---|
| author | Shiwan Tao Yamin Zhang Yamin Zhang Qiang Wang Chunxia Qiao Wei Deng Wei Deng Sugai Liang Sugai Liang Jinxue Wei Wei Wei Wei Wei Hua Yu Hua Yu Xiaojing Li Xiaojing Li Mingli Li Wanjun Guo Wanjun Guo Xiaohong Ma Liansheng Zhao Tao Li Tao Li Tao Li |
| author_facet | Shiwan Tao Yamin Zhang Yamin Zhang Qiang Wang Chunxia Qiao Wei Deng Wei Deng Sugai Liang Sugai Liang Jinxue Wei Wei Wei Wei Wei Hua Yu Hua Yu Xiaojing Li Xiaojing Li Mingli Li Wanjun Guo Wanjun Guo Xiaohong Ma Liansheng Zhao Tao Li Tao Li Tao Li |
| author_sort | Shiwan Tao |
| collection | DOAJ |
| description | Emerging evidence has demonstrated overlapping biological abnormalities underlying schizophrenia (SCZ), bipolar disorder (BP), and major depressive disorder (MDD); these overlapping abnormalities help explain the high heterogeneity and the similarity of patients within and among diagnostic categories. This study aimed to identify transdiagnostic subtypes of these psychiatric disorders based on lipidomics abnormalities. We performed discriminant analysis to identify lipids that classified patients (N = 349, 112 with SCZ, 132 with BP, and 105 with MDD) and healthy controls (N = 198). Ten lipids that mainly regulate energy metabolism, inflammation, oxidative stress, and fatty acylation of proteins were identified. We found two subtypes (named Cluster 1 and Cluster 2 subtypes) across patients with SCZ, BP, and MDD by consensus clustering analysis based on the above 10 lipids. The distribution of clinical diagnosis, functional impairment measured by Global Assessment of Functioning (GAF) scales, and brain white matter abnormalities measured by fractional anisotropy (FA) and radial diffusivity (RD) differed in the two subtypes. Patients within the Cluster 2 subtype were mainly SCZ and BP patients and featured significantly elevated RD along the genu of corpus callosum (GCC) region and lower GAF scores than patients within the Cluster 1 subtype. The SCZ and BP patients within the Cluster 2 subtype shared similar biological patterns; that is, these patients had comparable brain white matter abnormalities and functional impairment, which is consistent with previous studies. Our findings indicate that peripheral lipid abnormalities might help identify homogeneous transdiagnostic subtypes across psychiatric disorders. |
| first_indexed | 2024-04-11T12:26:18Z |
| format | Article |
| id | doaj.art-e227586f9eef4bc1b4f216651163202c |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-11T12:26:18Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-e227586f9eef4bc1b4f216651163202c2022-12-22T04:23:57ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-09-011010.3389/fcell.2022.969575969575Identifying transdiagnostic biological subtypes across schizophrenia, bipolar disorder, and major depressive disorder based on lipidomics profilesShiwan Tao0Yamin Zhang1Yamin Zhang2Qiang Wang3Chunxia Qiao4Wei Deng5Wei Deng6Sugai Liang7Sugai Liang8Jinxue Wei9Wei Wei10Wei Wei11Hua Yu12Hua Yu13Xiaojing Li14Xiaojing Li15Mingli Li16Wanjun Guo17Wanjun Guo18Xiaohong Ma19Liansheng Zhao20Tao Li21Tao Li22Tao Li23Mental Health Center and Psychiatric Laboratory, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaNHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaMental Health Center and Psychiatric Laboratory, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaMental Health Center and Psychiatric Laboratory, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaNHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaNHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaMental Health Center and Psychiatric Laboratory, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaNHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaNHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaNHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaMental Health Center and Psychiatric Laboratory, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaNHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaMental Health Center and Psychiatric Laboratory, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaMental Health Center and Psychiatric Laboratory, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaNHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaGuangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangzhou, ChinaEmerging evidence has demonstrated overlapping biological abnormalities underlying schizophrenia (SCZ), bipolar disorder (BP), and major depressive disorder (MDD); these overlapping abnormalities help explain the high heterogeneity and the similarity of patients within and among diagnostic categories. This study aimed to identify transdiagnostic subtypes of these psychiatric disorders based on lipidomics abnormalities. We performed discriminant analysis to identify lipids that classified patients (N = 349, 112 with SCZ, 132 with BP, and 105 with MDD) and healthy controls (N = 198). Ten lipids that mainly regulate energy metabolism, inflammation, oxidative stress, and fatty acylation of proteins were identified. We found two subtypes (named Cluster 1 and Cluster 2 subtypes) across patients with SCZ, BP, and MDD by consensus clustering analysis based on the above 10 lipids. The distribution of clinical diagnosis, functional impairment measured by Global Assessment of Functioning (GAF) scales, and brain white matter abnormalities measured by fractional anisotropy (FA) and radial diffusivity (RD) differed in the two subtypes. Patients within the Cluster 2 subtype were mainly SCZ and BP patients and featured significantly elevated RD along the genu of corpus callosum (GCC) region and lower GAF scores than patients within the Cluster 1 subtype. The SCZ and BP patients within the Cluster 2 subtype shared similar biological patterns; that is, these patients had comparable brain white matter abnormalities and functional impairment, which is consistent with previous studies. Our findings indicate that peripheral lipid abnormalities might help identify homogeneous transdiagnostic subtypes across psychiatric disorders.https://www.frontiersin.org/articles/10.3389/fcell.2022.969575/fullschizophreniabipolar disordermajor depressive disorderlipidomics profilebrain whiter matter |
| spellingShingle | Shiwan Tao Yamin Zhang Yamin Zhang Qiang Wang Chunxia Qiao Wei Deng Wei Deng Sugai Liang Sugai Liang Jinxue Wei Wei Wei Wei Wei Hua Yu Hua Yu Xiaojing Li Xiaojing Li Mingli Li Wanjun Guo Wanjun Guo Xiaohong Ma Liansheng Zhao Tao Li Tao Li Tao Li Identifying transdiagnostic biological subtypes across schizophrenia, bipolar disorder, and major depressive disorder based on lipidomics profiles Frontiers in Cell and Developmental Biology schizophrenia bipolar disorder major depressive disorder lipidomics profile brain whiter matter |
| title | Identifying transdiagnostic biological subtypes across schizophrenia, bipolar disorder, and major depressive disorder based on lipidomics profiles |
| title_full | Identifying transdiagnostic biological subtypes across schizophrenia, bipolar disorder, and major depressive disorder based on lipidomics profiles |
| title_fullStr | Identifying transdiagnostic biological subtypes across schizophrenia, bipolar disorder, and major depressive disorder based on lipidomics profiles |
| title_full_unstemmed | Identifying transdiagnostic biological subtypes across schizophrenia, bipolar disorder, and major depressive disorder based on lipidomics profiles |
| title_short | Identifying transdiagnostic biological subtypes across schizophrenia, bipolar disorder, and major depressive disorder based on lipidomics profiles |
| title_sort | identifying transdiagnostic biological subtypes across schizophrenia bipolar disorder and major depressive disorder based on lipidomics profiles |
| topic | schizophrenia bipolar disorder major depressive disorder lipidomics profile brain whiter matter |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.969575/full |
| work_keys_str_mv | AT shiwantao identifyingtransdiagnosticbiologicalsubtypesacrossschizophreniabipolardisorderandmajordepressivedisorderbasedonlipidomicsprofiles AT yaminzhang identifyingtransdiagnosticbiologicalsubtypesacrossschizophreniabipolardisorderandmajordepressivedisorderbasedonlipidomicsprofiles AT yaminzhang identifyingtransdiagnosticbiologicalsubtypesacrossschizophreniabipolardisorderandmajordepressivedisorderbasedonlipidomicsprofiles AT qiangwang identifyingtransdiagnosticbiologicalsubtypesacrossschizophreniabipolardisorderandmajordepressivedisorderbasedonlipidomicsprofiles AT chunxiaqiao identifyingtransdiagnosticbiologicalsubtypesacrossschizophreniabipolardisorderandmajordepressivedisorderbasedonlipidomicsprofiles AT weideng identifyingtransdiagnosticbiologicalsubtypesacrossschizophreniabipolardisorderandmajordepressivedisorderbasedonlipidomicsprofiles AT weideng identifyingtransdiagnosticbiologicalsubtypesacrossschizophreniabipolardisorderandmajordepressivedisorderbasedonlipidomicsprofiles AT sugailiang identifyingtransdiagnosticbiologicalsubtypesacrossschizophreniabipolardisorderandmajordepressivedisorderbasedonlipidomicsprofiles AT sugailiang identifyingtransdiagnosticbiologicalsubtypesacrossschizophreniabipolardisorderandmajordepressivedisorderbasedonlipidomicsprofiles AT jinxuewei identifyingtransdiagnosticbiologicalsubtypesacrossschizophreniabipolardisorderandmajordepressivedisorderbasedonlipidomicsprofiles AT weiwei identifyingtransdiagnosticbiologicalsubtypesacrossschizophreniabipolardisorderandmajordepressivedisorderbasedonlipidomicsprofiles AT weiwei identifyingtransdiagnosticbiologicalsubtypesacrossschizophreniabipolardisorderandmajordepressivedisorderbasedonlipidomicsprofiles AT huayu identifyingtransdiagnosticbiologicalsubtypesacrossschizophreniabipolardisorderandmajordepressivedisorderbasedonlipidomicsprofiles AT huayu identifyingtransdiagnosticbiologicalsubtypesacrossschizophreniabipolardisorderandmajordepressivedisorderbasedonlipidomicsprofiles AT xiaojingli identifyingtransdiagnosticbiologicalsubtypesacrossschizophreniabipolardisorderandmajordepressivedisorderbasedonlipidomicsprofiles AT xiaojingli identifyingtransdiagnosticbiologicalsubtypesacrossschizophreniabipolardisorderandmajordepressivedisorderbasedonlipidomicsprofiles AT minglili identifyingtransdiagnosticbiologicalsubtypesacrossschizophreniabipolardisorderandmajordepressivedisorderbasedonlipidomicsprofiles AT wanjunguo identifyingtransdiagnosticbiologicalsubtypesacrossschizophreniabipolardisorderandmajordepressivedisorderbasedonlipidomicsprofiles AT wanjunguo identifyingtransdiagnosticbiologicalsubtypesacrossschizophreniabipolardisorderandmajordepressivedisorderbasedonlipidomicsprofiles AT xiaohongma identifyingtransdiagnosticbiologicalsubtypesacrossschizophreniabipolardisorderandmajordepressivedisorderbasedonlipidomicsprofiles AT lianshengzhao identifyingtransdiagnosticbiologicalsubtypesacrossschizophreniabipolardisorderandmajordepressivedisorderbasedonlipidomicsprofiles AT taoli identifyingtransdiagnosticbiologicalsubtypesacrossschizophreniabipolardisorderandmajordepressivedisorderbasedonlipidomicsprofiles AT taoli identifyingtransdiagnosticbiologicalsubtypesacrossschizophreniabipolardisorderandmajordepressivedisorderbasedonlipidomicsprofiles AT taoli identifyingtransdiagnosticbiologicalsubtypesacrossschizophreniabipolardisorderandmajordepressivedisorderbasedonlipidomicsprofiles |