Trypanocidal Activity of Oxoaporphine and Pyrimidine-β-Carboline Alkaloids from the Branches of Annona foetida Mart. (Annonaceae)

Trypanocidal Activity of Oxoaporphine and Pyrimidine-β-Carboline Alkaloids from the Branches of Annona foetida Mart. (Annonaceae)

Phytochemical investigation of the branches of Annona foetida Mart. led to isolation from the CH2Cl2 extract of four alkaloids: Atherospermidine (1), described for the first time in this species, liriodenine (2), O-methylmoschatoline (3), and annomontine (4). Their chemical structures were establish...

Full description

Bibliographic Details
Main Authors: Celso Vataru Nakamura, Benedito Prado Dias Filho, Rodrigo Hinojosa Valdez, Tânia Ueda-Nakamura, Francinete Ramos Campos, Andersson Barison, Afonso Duarte Leão de Souza, Emmanoel Vilaça Costa, Maria Lúcia Belém Pinheiro
Format: Article
Language:English
Published: MDPI AG 2011-11-01
Series:Molecules
Subjects:
annonaceae
Annona foetida
alkaloids
oxoaporphine alkaloids
pyrimidine-β-carboline alkaloids
trypanocidal activity
Online Access:http://www.mdpi.com/1420-3049/16/11/9714/
Description
Summary:Phytochemical investigation of the branches of Annona foetida Mart. led to isolation from the CH2Cl2 extract of four alkaloids: Atherospermidine (1), described for the first time in this species, liriodenine (2), O-methylmoschatoline (3), and annomontine (4). Their chemical structures were established on the basis of spectroscopic data from IR, MS, NMR (1D and 2D), and comparison with the literature. Compounds 2–4 showed potent trypanocidal effect when evaluated against epimastigote and trypomastigote forms of Trypanosoma cruzi.
ISSN:1420-3049

Similar Items