Trypanocidal Activity of Oxoaporphine and Pyrimidine-β-Carboline Alkaloids from the Branches of Annona foetida Mart. (Annonaceae)
Phytochemical investigation of the branches of Annona foetida Mart. led to isolation from the CH2Cl2 extract of four alkaloids: Atherospermidine (1), described for the first time in this species, liriodenine (2), O-methylmoschatoline (3), and annomontine (4). Their chemical structures were establish...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2011-11-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/16/11/9714/ |
| _version_ | 1828773301137178624 |
|---|---|
| author | Celso Vataru Nakamura Benedito Prado Dias Filho Rodrigo Hinojosa Valdez Tânia Ueda-Nakamura Francinete Ramos Campos Andersson Barison Afonso Duarte Leão de Souza Emmanoel Vilaça Costa Maria Lúcia Belém Pinheiro |
| author_facet | Celso Vataru Nakamura Benedito Prado Dias Filho Rodrigo Hinojosa Valdez Tânia Ueda-Nakamura Francinete Ramos Campos Andersson Barison Afonso Duarte Leão de Souza Emmanoel Vilaça Costa Maria Lúcia Belém Pinheiro |
| author_sort | Celso Vataru Nakamura |
| collection | DOAJ |
| description | Phytochemical investigation of the branches of Annona foetida Mart. led to isolation from the CH2Cl2 extract of four alkaloids: Atherospermidine (1), described for the first time in this species, liriodenine (2), O-methylmoschatoline (3), and annomontine (4). Their chemical structures were established on the basis of spectroscopic data from IR, MS, NMR (1D and 2D), and comparison with the literature. Compounds 2–4 showed potent trypanocidal effect when evaluated against epimastigote and trypomastigote forms of Trypanosoma cruzi. |
| first_indexed | 2024-12-11T15:00:41Z |
| format | Article |
| id | doaj.art-e228dba2119b4f439e8680c0fa8aa46f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T15:00:41Z |
| publishDate | 2011-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e228dba2119b4f439e8680c0fa8aa46f2022-12-22T01:01:10ZengMDPI AGMolecules1420-30492011-11-0116119714972010.3390/molecules16119714Trypanocidal Activity of Oxoaporphine and Pyrimidine-β-Carboline Alkaloids from the Branches of Annona foetida Mart. (Annonaceae)Celso Vataru NakamuraBenedito Prado Dias FilhoRodrigo Hinojosa ValdezTânia Ueda-NakamuraFrancinete Ramos CamposAndersson BarisonAfonso Duarte Leão de SouzaEmmanoel Vilaça CostaMaria Lúcia Belém PinheiroPhytochemical investigation of the branches of Annona foetida Mart. led to isolation from the CH2Cl2 extract of four alkaloids: Atherospermidine (1), described for the first time in this species, liriodenine (2), O-methylmoschatoline (3), and annomontine (4). Their chemical structures were established on the basis of spectroscopic data from IR, MS, NMR (1D and 2D), and comparison with the literature. Compounds 2–4 showed potent trypanocidal effect when evaluated against epimastigote and trypomastigote forms of Trypanosoma cruzi.http://www.mdpi.com/1420-3049/16/11/9714/annonaceaeAnnona foetidaalkaloidsoxoaporphine alkaloidspyrimidine-β-carboline alkaloidstrypanocidal activity |
| spellingShingle | Celso Vataru Nakamura Benedito Prado Dias Filho Rodrigo Hinojosa Valdez Tânia Ueda-Nakamura Francinete Ramos Campos Andersson Barison Afonso Duarte Leão de Souza Emmanoel Vilaça Costa Maria Lúcia Belém Pinheiro Trypanocidal Activity of Oxoaporphine and Pyrimidine-β-Carboline Alkaloids from the Branches of Annona foetida Mart. (Annonaceae) Molecules annonaceae Annona foetida alkaloids oxoaporphine alkaloids pyrimidine-β-carboline alkaloids trypanocidal activity |
| title | Trypanocidal Activity of Oxoaporphine and Pyrimidine-β-Carboline Alkaloids from the Branches of Annona foetida Mart. (Annonaceae) |
| title_full | Trypanocidal Activity of Oxoaporphine and Pyrimidine-β-Carboline Alkaloids from the Branches of Annona foetida Mart. (Annonaceae) |
| title_fullStr | Trypanocidal Activity of Oxoaporphine and Pyrimidine-β-Carboline Alkaloids from the Branches of Annona foetida Mart. (Annonaceae) |
| title_full_unstemmed | Trypanocidal Activity of Oxoaporphine and Pyrimidine-β-Carboline Alkaloids from the Branches of Annona foetida Mart. (Annonaceae) |
| title_short | Trypanocidal Activity of Oxoaporphine and Pyrimidine-β-Carboline Alkaloids from the Branches of Annona foetida Mart. (Annonaceae) |
| title_sort | trypanocidal activity of oxoaporphine and pyrimidine β carboline alkaloids from the branches of annona foetida mart annonaceae |
| topic | annonaceae Annona foetida alkaloids oxoaporphine alkaloids pyrimidine-β-carboline alkaloids trypanocidal activity |
| url | http://www.mdpi.com/1420-3049/16/11/9714/ |
| work_keys_str_mv | AT celsovatarunakamura trypanocidalactivityofoxoaporphineandpyrimidinebcarbolinealkaloidsfromthebranchesofannonafoetidamartannonaceae AT beneditopradodiasfilho trypanocidalactivityofoxoaporphineandpyrimidinebcarbolinealkaloidsfromthebranchesofannonafoetidamartannonaceae AT rodrigohinojosavaldez trypanocidalactivityofoxoaporphineandpyrimidinebcarbolinealkaloidsfromthebranchesofannonafoetidamartannonaceae AT taniauedanakamura trypanocidalactivityofoxoaporphineandpyrimidinebcarbolinealkaloidsfromthebranchesofannonafoetidamartannonaceae AT francineteramoscampos trypanocidalactivityofoxoaporphineandpyrimidinebcarbolinealkaloidsfromthebranchesofannonafoetidamartannonaceae AT anderssonbarison trypanocidalactivityofoxoaporphineandpyrimidinebcarbolinealkaloidsfromthebranchesofannonafoetidamartannonaceae AT afonsoduarteleaodesouza trypanocidalactivityofoxoaporphineandpyrimidinebcarbolinealkaloidsfromthebranchesofannonafoetidamartannonaceae AT emmanoelvilacacosta trypanocidalactivityofoxoaporphineandpyrimidinebcarbolinealkaloidsfromthebranchesofannonafoetidamartannonaceae AT marialuciabelempinheiro trypanocidalactivityofoxoaporphineandpyrimidinebcarbolinealkaloidsfromthebranchesofannonafoetidamartannonaceae |