A consensus-based framework for conducting and reporting osteoarthritis phenotype research
Abstract Background The concept of osteoarthritis (OA) heterogeneity is evolving and gaining renewed interest. According to this concept, distinct subtypes of OA need to be defined that will likely require recognition in research design and different approaches to clinical management. Although seemi...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-03-01
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| Series: | Arthritis Research & Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13075-020-2143-0 |
| _version_ | 1811341885170515968 |
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| author | W. E. van Spil S. M. A. Bierma-Zeinstra L. A. Deveza N. K. Arden A.-C. Bay-Jensen V. Byers Kraus L. Carlesso R. Christensen M. Van Der Esch P. Kent J. Knoop C. Ladel C. B. Little R. F. Loeser E. Losina K. Mills A. Mobasheri A. E. Nelson T. Neogi G. M. Peat A.-C. Rat M. Steultjens M. J. Thomas A. M. Valdes D. J. Hunter |
| author_facet | W. E. van Spil S. M. A. Bierma-Zeinstra L. A. Deveza N. K. Arden A.-C. Bay-Jensen V. Byers Kraus L. Carlesso R. Christensen M. Van Der Esch P. Kent J. Knoop C. Ladel C. B. Little R. F. Loeser E. Losina K. Mills A. Mobasheri A. E. Nelson T. Neogi G. M. Peat A.-C. Rat M. Steultjens M. J. Thomas A. M. Valdes D. J. Hunter |
| author_sort | W. E. van Spil |
| collection | DOAJ |
| description | Abstract Background The concept of osteoarthritis (OA) heterogeneity is evolving and gaining renewed interest. According to this concept, distinct subtypes of OA need to be defined that will likely require recognition in research design and different approaches to clinical management. Although seemingly plausible, a wide range of views exist on how best to operationalize this concept. The current project aimed to provide consensus-based definitions and recommendations that together create a framework for conducting and reporting OA phenotype research. Methods A panel of 25 members with expertise in OA phenotype research was composed. First, panel members participated in an online Delphi exercise to provide a number of basic definitions and statements relating to OA phenotypes and OA phenotype research. Second, panel members provided input on a set of recommendations for reporting on OA phenotype studies. Results Four Delphi rounds were required to achieve sufficient agreement on 11 definitions and statements. OA phenotypes were defined as subtypes of OA that share distinct underlying pathobiological and pain mechanisms and their structural and functional consequences. Reporting recommendations pertaining to the study characteristics, study population, data collection, statistical analysis, and appraisal of OA phenotype studies were provided. Conclusions This study provides a number of consensus-based definitions and recommendations relating to OA phenotypes. The resulting framework is intended to facilitate research on OA phenotypes and increase combined efforts to develop effective OA phenotype classification. Success in this endeavor will hopefully translate into more effective, differentiated OA management that will benefit a multitude of OA patients. |
| first_indexed | 2024-04-13T19:01:50Z |
| format | Article |
| id | doaj.art-e22916499500441283781d1e22a1d712 |
| institution | Directory Open Access Journal |
| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-04-13T19:01:50Z |
| publishDate | 2020-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj.art-e22916499500441283781d1e22a1d7122022-12-22T02:34:05ZengBMCArthritis Research & Therapy1478-63622020-03-012211710.1186/s13075-020-2143-0A consensus-based framework for conducting and reporting osteoarthritis phenotype researchW. E. van Spil0S. M. A. Bierma-Zeinstra1L. A. Deveza2N. K. Arden3A.-C. Bay-Jensen4V. Byers Kraus5L. Carlesso6R. Christensen7M. Van Der Esch8P. Kent9J. Knoop10C. Ladel11C. B. Little12R. F. Loeser13E. Losina14K. Mills15A. Mobasheri16A. E. Nelson17T. Neogi18G. M. Peat19A.-C. Rat20M. Steultjens21M. J. Thomas22A. M. Valdes23D. J. Hunter24Department of Rheumatology & Clinical Immunology, University Medical Center UtrechtDepartment of General Practice, Erasmus MC University Medical Center RotterdamDepartment of Rheumatology, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of SydneyUniversity of OxfordRheumatology, Nordic BioscienceSchool of Medicine, Duke UniversityUniversité de MontréalMusculoskeletal Statistics Unit, The Parker Institute, Copenhagen University Hospital, Bispebjerg and FrederiksbergReade, Center of Rehabilitation and RheumatologyCurtin UniversityDepartment of Health Sciences, VU AmsterdamMerck KGaARaymond Purves Labs, Institute of Bone and Joint Research, Kolling Institute, University of SydneyThurston Arthritis Research Center, University of North CarolinaBrigham and Women’s HospitalDepartment of Health Professions, Macquarie UniversityResearch Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of OuluThurston Arthritis Research Center, University of North CarolinaSchool of Medicine, Boston UniversityArthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele UniversityUniversité de LorraineSchool of Health and Life Sciences, Glasgow Caledonian UniversityArthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele UniversitySchool of Medicine, University of NottinghamDepartment of Rheumatology, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of SydneyAbstract Background The concept of osteoarthritis (OA) heterogeneity is evolving and gaining renewed interest. According to this concept, distinct subtypes of OA need to be defined that will likely require recognition in research design and different approaches to clinical management. Although seemingly plausible, a wide range of views exist on how best to operationalize this concept. The current project aimed to provide consensus-based definitions and recommendations that together create a framework for conducting and reporting OA phenotype research. Methods A panel of 25 members with expertise in OA phenotype research was composed. First, panel members participated in an online Delphi exercise to provide a number of basic definitions and statements relating to OA phenotypes and OA phenotype research. Second, panel members provided input on a set of recommendations for reporting on OA phenotype studies. Results Four Delphi rounds were required to achieve sufficient agreement on 11 definitions and statements. OA phenotypes were defined as subtypes of OA that share distinct underlying pathobiological and pain mechanisms and their structural and functional consequences. Reporting recommendations pertaining to the study characteristics, study population, data collection, statistical analysis, and appraisal of OA phenotype studies were provided. Conclusions This study provides a number of consensus-based definitions and recommendations relating to OA phenotypes. The resulting framework is intended to facilitate research on OA phenotypes and increase combined efforts to develop effective OA phenotype classification. Success in this endeavor will hopefully translate into more effective, differentiated OA management that will benefit a multitude of OA patients.http://link.springer.com/article/10.1186/s13075-020-2143-0OsteoarthritisPhenotypesFrameworkConsensus (maximum 10) |
| spellingShingle | W. E. van Spil S. M. A. Bierma-Zeinstra L. A. Deveza N. K. Arden A.-C. Bay-Jensen V. Byers Kraus L. Carlesso R. Christensen M. Van Der Esch P. Kent J. Knoop C. Ladel C. B. Little R. F. Loeser E. Losina K. Mills A. Mobasheri A. E. Nelson T. Neogi G. M. Peat A.-C. Rat M. Steultjens M. J. Thomas A. M. Valdes D. J. Hunter A consensus-based framework for conducting and reporting osteoarthritis phenotype research Arthritis Research & Therapy Osteoarthritis Phenotypes Framework Consensus (maximum 10) |
| title | A consensus-based framework for conducting and reporting osteoarthritis phenotype research |
| title_full | A consensus-based framework for conducting and reporting osteoarthritis phenotype research |
| title_fullStr | A consensus-based framework for conducting and reporting osteoarthritis phenotype research |
| title_full_unstemmed | A consensus-based framework for conducting and reporting osteoarthritis phenotype research |
| title_short | A consensus-based framework for conducting and reporting osteoarthritis phenotype research |
| title_sort | consensus based framework for conducting and reporting osteoarthritis phenotype research |
| topic | Osteoarthritis Phenotypes Framework Consensus (maximum 10) |
| url | http://link.springer.com/article/10.1186/s13075-020-2143-0 |
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