Metabolic Constellations, Clusters, and Renal Function: Findings from the 2013–2018 National Health and Nutrition Examination Surveys
Metabolic syndrome (MetS) is associated with decreased renal function and chronic kidney disease (CKD). To date, no research regarding the sixteen possible constellations resulting in the diagnosis of MetS has been elucidated. The purpose of this study is to report renal function in sixteen metaboli...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-08-01
|
| Series: | Life |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-1729/11/9/904 |
| _version_ | 1797518514137858048 |
|---|---|
| author | Kathleen E. Adair Kelly R. Ylitalo Jeffrey S. Forsse LesLee K. Funderburk Rodney G. Bowden |
| author_facet | Kathleen E. Adair Kelly R. Ylitalo Jeffrey S. Forsse LesLee K. Funderburk Rodney G. Bowden |
| author_sort | Kathleen E. Adair |
| collection | DOAJ |
| description | Metabolic syndrome (MetS) is associated with decreased renal function and chronic kidney disease (CKD). To date, no research regarding the sixteen possible constellations resulting in the diagnosis of MetS has been elucidated. The purpose of this study is to report renal function in sixteen metabolic constellations grouped into four metabolic clusters. Individuals (n = 2767; representing 86,652,073 individuals) from the 2013–2018 National Health and Nutrition Examination Surveys who met the criteria for MetS were included. Sixteen possible constellations of three or more risk factors were analyzed for renal function. Four metabolic clusters representing MetS with hyperglycemia (Cluster I), MetS with hypertension (Cluster II), MetS with hyperglycemia and hypertension (Cluster III), or MetS with normoglycemia and normotension (Cluster IV) were assessed for renal function and CKD status. Cluster III had the highest odds of CKD (OR = 2.57, 95% CL = 1.79, 3.68). Clusters II and III had the lowest renal function and were not different from one another (87.82 and 87.28 mL/min/1.73 m<sup>2</sup>, <i>p</i> = 0.71). The constellation with the lowest renal function consisted of hypertension, high triglycerides, and a large waist circumference (82.86 mL/min/1.73 m<sup>2</sup>), whereas the constellation with the highest renal function consisted of hyperglycemia, low HDL, and a large waist circumference (107.46 mL/min/1.73 m<sup>2</sup>). The sixteen constellations of MetS do not have the same effects on renal function. More research is needed to understand the relationship between the various iterations of MetS and renal function. |
| first_indexed | 2024-03-10T07:30:26Z |
| format | Article |
| id | doaj.art-e2293c0da4f54d22a8253dbd4df83ab7 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T07:30:26Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-e2293c0da4f54d22a8253dbd4df83ab72023-11-22T13:55:39ZengMDPI AGLife2075-17292021-08-0111990410.3390/life11090904Metabolic Constellations, Clusters, and Renal Function: Findings from the 2013–2018 National Health and Nutrition Examination SurveysKathleen E. Adair0Kelly R. Ylitalo1Jeffrey S. Forsse2LesLee K. Funderburk3Rodney G. Bowden4Department of Health, Human Performance, and Recreation, Robbins College of Health and Human Sciences, Baylor University, Waco, TX 76798, USADepartment of Public Health, Robbins College of Health and Human Sciences, Baylor University, Waco, TX 76798, USADepartment of Health, Human Performance, and Recreation, Robbins College of Health and Human Sciences, Baylor University, Waco, TX 76798, USADepartment of Health, Human Performance, and Recreation, Robbins College of Health and Human Sciences, Baylor University, Waco, TX 76798, USADepartment of Public Health, Robbins College of Health and Human Sciences, Baylor University, Waco, TX 76798, USAMetabolic syndrome (MetS) is associated with decreased renal function and chronic kidney disease (CKD). To date, no research regarding the sixteen possible constellations resulting in the diagnosis of MetS has been elucidated. The purpose of this study is to report renal function in sixteen metabolic constellations grouped into four metabolic clusters. Individuals (n = 2767; representing 86,652,073 individuals) from the 2013–2018 National Health and Nutrition Examination Surveys who met the criteria for MetS were included. Sixteen possible constellations of three or more risk factors were analyzed for renal function. Four metabolic clusters representing MetS with hyperglycemia (Cluster I), MetS with hypertension (Cluster II), MetS with hyperglycemia and hypertension (Cluster III), or MetS with normoglycemia and normotension (Cluster IV) were assessed for renal function and CKD status. Cluster III had the highest odds of CKD (OR = 2.57, 95% CL = 1.79, 3.68). Clusters II and III had the lowest renal function and were not different from one another (87.82 and 87.28 mL/min/1.73 m<sup>2</sup>, <i>p</i> = 0.71). The constellation with the lowest renal function consisted of hypertension, high triglycerides, and a large waist circumference (82.86 mL/min/1.73 m<sup>2</sup>), whereas the constellation with the highest renal function consisted of hyperglycemia, low HDL, and a large waist circumference (107.46 mL/min/1.73 m<sup>2</sup>). The sixteen constellations of MetS do not have the same effects on renal function. More research is needed to understand the relationship between the various iterations of MetS and renal function.https://www.mdpi.com/2075-1729/11/9/904metabolic syndromemetabolic constellationsmetabolic clusterschronic kidney diseaserenal function |
| spellingShingle | Kathleen E. Adair Kelly R. Ylitalo Jeffrey S. Forsse LesLee K. Funderburk Rodney G. Bowden Metabolic Constellations, Clusters, and Renal Function: Findings from the 2013–2018 National Health and Nutrition Examination Surveys Life metabolic syndrome metabolic constellations metabolic clusters chronic kidney disease renal function |
| title | Metabolic Constellations, Clusters, and Renal Function: Findings from the 2013–2018 National Health and Nutrition Examination Surveys |
| title_full | Metabolic Constellations, Clusters, and Renal Function: Findings from the 2013–2018 National Health and Nutrition Examination Surveys |
| title_fullStr | Metabolic Constellations, Clusters, and Renal Function: Findings from the 2013–2018 National Health and Nutrition Examination Surveys |
| title_full_unstemmed | Metabolic Constellations, Clusters, and Renal Function: Findings from the 2013–2018 National Health and Nutrition Examination Surveys |
| title_short | Metabolic Constellations, Clusters, and Renal Function: Findings from the 2013–2018 National Health and Nutrition Examination Surveys |
| title_sort | metabolic constellations clusters and renal function findings from the 2013 2018 national health and nutrition examination surveys |
| topic | metabolic syndrome metabolic constellations metabolic clusters chronic kidney disease renal function |
| url | https://www.mdpi.com/2075-1729/11/9/904 |
| work_keys_str_mv | AT kathleeneadair metabolicconstellationsclustersandrenalfunctionfindingsfromthe20132018nationalhealthandnutritionexaminationsurveys AT kellyrylitalo metabolicconstellationsclustersandrenalfunctionfindingsfromthe20132018nationalhealthandnutritionexaminationsurveys AT jeffreysforsse metabolicconstellationsclustersandrenalfunctionfindingsfromthe20132018nationalhealthandnutritionexaminationsurveys AT lesleekfunderburk metabolicconstellationsclustersandrenalfunctionfindingsfromthe20132018nationalhealthandnutritionexaminationsurveys AT rodneygbowden metabolicconstellationsclustersandrenalfunctionfindingsfromthe20132018nationalhealthandnutritionexaminationsurveys |