Effect of Qingguang’an II on expressions of OX42 protein and IL-1β mRNA of retinal microglia cells of rats with chronic high intraocular pressure
The study investigated the effects of Qingguang’an II (a Chinese medicinal preparation) on expressions of OX42 protein and interleukin-1β (IL-1β) mRNA of retinal microglia cells of rats with chronic high intraocular pressure (IOP). SD rats were randomly divided into 6 groups, that were: A: blank gro...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2018-02-01
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| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.cn/en_publish/2018/2/20180223.pdf |
| _version_ | 1811216602758119424 |
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| author | Ya-Sha Zhou Jian Xu Jun Peng Yue Liu Gen-Yan Qin Yi-Jing Yang Qing-Hua Peng Han-Yu Tan |
| author_facet | Ya-Sha Zhou Jian Xu Jun Peng Yue Liu Gen-Yan Qin Yi-Jing Yang Qing-Hua Peng Han-Yu Tan |
| author_sort | Ya-Sha Zhou |
| collection | DOAJ |
| description | The study investigated the effects of Qingguang’an II (a Chinese medicinal preparation) on expressions of OX42 protein and interleukin-1β (IL-1β) mRNA of retinal microglia cells of rats with chronic high intraocular pressure (IOP). SD rats were randomly divided into 6 groups, that were: A: blank group; B: model group; C: Qingguang’an II low dose group; D: Qingguang’an II medium dose group; E: Qingguang’an II high dose group; F: Yimaikang disket (a Chinese medicinal preparation) group. Experimental rats in B, C, D, E, F groups were established the model of chronic high IOP by cauterizing of superficial scleral vein. Tissues of eyes were obtained after intragastric administration for 2 and 4wk. At the time-point of 2wk, OX42 protein and IL-1β mRNA in group B were statistically expressed in higher level comparing with other groups (P<0.05). Moreover, at the time-point of 4wk, OX42 protein and IL-1β mRNA in groups C, D and E were statistically expressed in lower level comparing with group F (P<0.05). Besides, OX42 protein and IL-1β mRNA in groups C and D were statistically expressed in higher level comparing with group E (P<0.05). OX42 protein and IL-1β mRNA in groups C and D were expressed in similar level (P>0.05). The study indicated that, in the protection of optic nerve of rats with chronic high IOP, the high dose of Qingguang’an II at the time-point of 4wk was the better choice. |
| first_indexed | 2024-04-12T06:43:08Z |
| format | Article |
| id | doaj.art-e22afe05ff5a45f5a75b1eda03c415fd |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-04-12T06:43:08Z |
| publishDate | 2018-02-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-e22afe05ff5a45f5a75b1eda03c415fd2022-12-22T03:43:41ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982018-02-0111232632810.18240/ijo.2018.02.23Effect of Qingguang’an II on expressions of OX42 protein and IL-1β mRNA of retinal microglia cells of rats with chronic high intraocular pressureYa-Sha Zhou0Jian Xu1Jun Peng2Yue Liu3Gen-Yan Qin4Yi-Jing Yang5Qing-Hua Peng6Han-Yu Tan7Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan Province, ChinaHunan University of Traditional Chinese Medicine, Changsha 410208, Hunan Province, ChinaThe First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha 410007, Hunan Province, ChinaHunan University of Traditional Chinese Medicine, Changsha 410208, Hunan Province, ChinaHunan University of Traditional Chinese Medicine, Changsha 410208, Hunan Province, ChinaHunan University of Traditional Chinese Medicine, Changsha 410208, Hunan Province, ChinaHunan University of Traditional Chinese Medicine, Changsha 410208, Hunan Province, China; The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha 410007, Hunan Province, ChinaHunan University of Traditional Chinese Medicine, Changsha 410208, Hunan Province, ChinaThe study investigated the effects of Qingguang’an II (a Chinese medicinal preparation) on expressions of OX42 protein and interleukin-1β (IL-1β) mRNA of retinal microglia cells of rats with chronic high intraocular pressure (IOP). SD rats were randomly divided into 6 groups, that were: A: blank group; B: model group; C: Qingguang’an II low dose group; D: Qingguang’an II medium dose group; E: Qingguang’an II high dose group; F: Yimaikang disket (a Chinese medicinal preparation) group. Experimental rats in B, C, D, E, F groups were established the model of chronic high IOP by cauterizing of superficial scleral vein. Tissues of eyes were obtained after intragastric administration for 2 and 4wk. At the time-point of 2wk, OX42 protein and IL-1β mRNA in group B were statistically expressed in higher level comparing with other groups (P<0.05). Moreover, at the time-point of 4wk, OX42 protein and IL-1β mRNA in groups C, D and E were statistically expressed in lower level comparing with group F (P<0.05). Besides, OX42 protein and IL-1β mRNA in groups C and D were statistically expressed in higher level comparing with group E (P<0.05). OX42 protein and IL-1β mRNA in groups C and D were expressed in similar level (P>0.05). The study indicated that, in the protection of optic nerve of rats with chronic high IOP, the high dose of Qingguang’an II at the time-point of 4wk was the better choice.http://www.ijo.cn/en_publish/2018/2/20180223.pdf328Qingguang’an IIchronic high intraocular pressureOX42 proteininterleukin-1β mRNA |
| spellingShingle | Ya-Sha Zhou Jian Xu Jun Peng Yue Liu Gen-Yan Qin Yi-Jing Yang Qing-Hua Peng Han-Yu Tan Effect of Qingguang’an II on expressions of OX42 protein and IL-1β mRNA of retinal microglia cells of rats with chronic high intraocular pressure International Journal of Ophthalmology 328 Qingguang’an II chronic high intraocular pressure OX42 protein interleukin-1β mRNA |
| title | Effect of Qingguang’an II on expressions of OX42 protein and IL-1β mRNA of retinal microglia cells of rats with chronic high intraocular pressure |
| title_full | Effect of Qingguang’an II on expressions of OX42 protein and IL-1β mRNA of retinal microglia cells of rats with chronic high intraocular pressure |
| title_fullStr | Effect of Qingguang’an II on expressions of OX42 protein and IL-1β mRNA of retinal microglia cells of rats with chronic high intraocular pressure |
| title_full_unstemmed | Effect of Qingguang’an II on expressions of OX42 protein and IL-1β mRNA of retinal microglia cells of rats with chronic high intraocular pressure |
| title_short | Effect of Qingguang’an II on expressions of OX42 protein and IL-1β mRNA of retinal microglia cells of rats with chronic high intraocular pressure |
| title_sort | effect of qingguang an ii on expressions of ox42 protein and il 1β mrna of retinal microglia cells of rats with chronic high intraocular pressure |
| topic | 328 Qingguang’an II chronic high intraocular pressure OX42 protein interleukin-1β mRNA |
| url | http://www.ijo.cn/en_publish/2018/2/20180223.pdf |
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