Estrogens Play a Critical Role in Stress-Related Gastrointestinal Dysfunction in a Spontaneous Model of Disorders of Gut–Brain Interaction

Estrogens Play a Critical Role in Stress-Related Gastrointestinal Dysfunction in a Spontaneous Model of Disorders of Gut–Brain Interaction

Background: Disorders of the gut–brain interaction (DGBI), such as irritable bowel syndrome and functional dyspepsia, are more prevalent in women than in men, with a ratio of 2:1. Furthermore, stressful life events have been reported as one of the triggers for symptoms in DGBI patients. Methods: Her...

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Bibliographic Details
Main Authors: Alison Accarie, Joran Toth, Lucas Wauters, Ricard Farré, Jan Tack, Tim Vanuytsel
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cells
Subjects:
multifactorial DGBI model
β-estradiol
disorders of gut–brain interaction
irritable bowel syndrome
mast cells
visceral hypersensitivity
Online Access:https://www.mdpi.com/2073-4409/11/7/1214

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