Reference data for left ventricular filling and atrial function in children using cardiovascular magnetic resonance
Abstract Background Diastolic dysfunction is associated with morbidity and mortality in multiple pediatric disease processes. Cardiovascular magnetic resonance (CMR) provides a non-invasive method of studying left ventricular (LV) diastolic dysfunction through the assessment of LV filling curves an...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | Journal of Cardiovascular Magnetic Resonance |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12968-023-00936-x |
| _version_ | 1797801404172075008 |
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| author | Christopher C. Henderson Kristen George-Durrett Sandra Kikano James C. Slaughter Joshua D. Chew David Parra Jeffrey Weiner Jonathan Soslow |
| author_facet | Christopher C. Henderson Kristen George-Durrett Sandra Kikano James C. Slaughter Joshua D. Chew David Parra Jeffrey Weiner Jonathan Soslow |
| author_sort | Christopher C. Henderson |
| collection | DOAJ |
| description | Abstract Background Diastolic dysfunction is associated with morbidity and mortality in multiple pediatric disease processes. Cardiovascular magnetic resonance (CMR) provides a non-invasive method of studying left ventricular (LV) diastolic dysfunction through the assessment of LV filling curves and left atrial (LA) volume and function. However, there are no normative data for LV filling curves and the standard method is time-intensive. This study aims to compare an alternate, more rapid method of obtaining LV filling curves to standard methodology and report normative CMR diastolic function data for LV filling curves and LA volumes and function. Methods Ninety-six healthy pediatric subjects (14.3 ± 3.4 years) with normal CMR defined by normal biventricular size and systolic function without late gadolinium enhancement were included. LV filling curves were generated by removing basal slices without myocardium present throughout the cardiac cycle and apical slices with poor endocardial delineation (compressed method), then re-generated including every phase of myocardium from apex to base (standard method). Indices of diastolic function included peak filling rate and time to peak filling. Systolic metrics included peak ejection rate and time to peak ejection. Both peak ejection and peak filling rates were indexed to end-diastolic volume. LA maximum, minimum and pre-contraction volumes were calculated using a biplane method. Inter-and intra-observer variability were assessed with intraclass correlation coefficient. Multivariable linear regression was used to assess the effects of body surface area (BSA), gender and age on metrics of diastolic function. Results BSA had the largest effect on LV filling curves. Normal LV filling data are reported for both compressed and standard methods. The time to perform the compressed method was significantly shorter than the standard method (median 6.1 min vs. 12.5 min, p < 0.001). Both methods had strong to moderate correlation for all metrics. Intra-observer reproducibility was moderate to high for all LV filling and LA metrics except for time to peak ejection and peak filling. Conclusions We report reference values for LV filling metrics and LA volumes. The compressed method is more rapid and produces similar results to standard methodology, which may facilitate the use of LV filling in clinical CMR reporting. |
| first_indexed | 2024-03-13T04:49:57Z |
| format | Article |
| id | doaj.art-e22e82248ca34d8ba8ced9e8a5135cf2 |
| institution | Directory Open Access Journal |
| issn | 1532-429X |
| language | English |
| last_indexed | 2024-03-13T04:49:57Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiovascular Magnetic Resonance |
| spelling | doaj.art-e22e82248ca34d8ba8ced9e8a5135cf22023-06-18T11:17:36ZengBMCJournal of Cardiovascular Magnetic Resonance1532-429X2023-06-0125111210.1186/s12968-023-00936-xReference data for left ventricular filling and atrial function in children using cardiovascular magnetic resonanceChristopher C. Henderson0Kristen George-Durrett1Sandra Kikano2James C. Slaughter3Joshua D. Chew4David Parra5Jeffrey Weiner6Jonathan Soslow7Department of Pediatrics, Vanderbilt University Medical CenterDivision of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical CenterDivision of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical CenterDepartment of Biostatistics, Vanderbilt University School of MedicineDivision of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical CenterDivision of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical CenterDivision of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical CenterDivision of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical CenterAbstract Background Diastolic dysfunction is associated with morbidity and mortality in multiple pediatric disease processes. Cardiovascular magnetic resonance (CMR) provides a non-invasive method of studying left ventricular (LV) diastolic dysfunction through the assessment of LV filling curves and left atrial (LA) volume and function. However, there are no normative data for LV filling curves and the standard method is time-intensive. This study aims to compare an alternate, more rapid method of obtaining LV filling curves to standard methodology and report normative CMR diastolic function data for LV filling curves and LA volumes and function. Methods Ninety-six healthy pediatric subjects (14.3 ± 3.4 years) with normal CMR defined by normal biventricular size and systolic function without late gadolinium enhancement were included. LV filling curves were generated by removing basal slices without myocardium present throughout the cardiac cycle and apical slices with poor endocardial delineation (compressed method), then re-generated including every phase of myocardium from apex to base (standard method). Indices of diastolic function included peak filling rate and time to peak filling. Systolic metrics included peak ejection rate and time to peak ejection. Both peak ejection and peak filling rates were indexed to end-diastolic volume. LA maximum, minimum and pre-contraction volumes were calculated using a biplane method. Inter-and intra-observer variability were assessed with intraclass correlation coefficient. Multivariable linear regression was used to assess the effects of body surface area (BSA), gender and age on metrics of diastolic function. Results BSA had the largest effect on LV filling curves. Normal LV filling data are reported for both compressed and standard methods. The time to perform the compressed method was significantly shorter than the standard method (median 6.1 min vs. 12.5 min, p < 0.001). Both methods had strong to moderate correlation for all metrics. Intra-observer reproducibility was moderate to high for all LV filling and LA metrics except for time to peak ejection and peak filling. Conclusions We report reference values for LV filling metrics and LA volumes. The compressed method is more rapid and produces similar results to standard methodology, which may facilitate the use of LV filling in clinical CMR reporting.https://doi.org/10.1186/s12968-023-00936-xDiastolic dysfunctionCardiovascular magnetic resonanceReference valuesChildren |
| spellingShingle | Christopher C. Henderson Kristen George-Durrett Sandra Kikano James C. Slaughter Joshua D. Chew David Parra Jeffrey Weiner Jonathan Soslow Reference data for left ventricular filling and atrial function in children using cardiovascular magnetic resonance Journal of Cardiovascular Magnetic Resonance Diastolic dysfunction Cardiovascular magnetic resonance Reference values Children |
| title | Reference data for left ventricular filling and atrial function in children using cardiovascular magnetic resonance |
| title_full | Reference data for left ventricular filling and atrial function in children using cardiovascular magnetic resonance |
| title_fullStr | Reference data for left ventricular filling and atrial function in children using cardiovascular magnetic resonance |
| title_full_unstemmed | Reference data for left ventricular filling and atrial function in children using cardiovascular magnetic resonance |
| title_short | Reference data for left ventricular filling and atrial function in children using cardiovascular magnetic resonance |
| title_sort | reference data for left ventricular filling and atrial function in children using cardiovascular magnetic resonance |
| topic | Diastolic dysfunction Cardiovascular magnetic resonance Reference values Children |
| url | https://doi.org/10.1186/s12968-023-00936-x |
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