| Summary: | The marine is a highly complex ecosystem including various microorganisms. <i>Bacillus</i> species is a predominant microbialflora widely distributed in marine ecosystems. This review aims to provide a systematic summary of the newly reported metabolites produced by marine-derived <i>Bacillus</i> species over recent years covering the literature from 2014 to 2021. It describes the structural diversity and biological activities of the reported compounds. Herein, a total of 87 newly reported metabolites are included in this article, among which 49 compounds originated from marine sediments, indicating that marine sediments are majority sources of productive strains of <i>Bacillus</i> species Therefore, marine-derived <i>Bacillus</i> species are a potentially promising source for the discovery of new metabolites.
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