Ocular side effects of Trametinib and Dabrafenib: a case report
Abstract A 53-year-old man who has stage 4 non-small cell lung carcinoma and treated with Dabrafenib-Trametinib combination chemotherapy; presented with decreased bilateral visual acuity. We checked out slit lamp examination, fundoscopy, optical coherence tomography and fundus fluorescein angiograph...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-04-01
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| Series: | Journal of Ophthalmic Inflammation and Infection |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12348-023-00339-0 |
| _version_ | 1797845841946345472 |
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| author | Bilge Tarım Meltem Kılıç |
| author_facet | Bilge Tarım Meltem Kılıç |
| author_sort | Bilge Tarım |
| collection | DOAJ |
| description | Abstract A 53-year-old man who has stage 4 non-small cell lung carcinoma and treated with Dabrafenib-Trametinib combination chemotherapy; presented with decreased bilateral visual acuity. We checked out slit lamp examination, fundoscopy, optical coherence tomography and fundus fluorescein angiography. In slit lamp biomicroscopy; bilateral posterior synechiae, granulomatous keratic precipitates and + 4 cells in the anterior chamber were detected. Cystoid macular edema and subretinal fluid accumulation were revealed in optical coherence tomography. Dabrafenib and Trametinib treatments were discontinued and systemic methylprednisolone, topical corticosteroid and topical cyclopentolate were started. His best corrected visual acuity was increased from counting fingers from 2 m to 0,9 bilaterally and cystoid macular edema and serous retinal detachment were completely regressed as a result of systemic and topical corticosteroid treatment. |
| first_indexed | 2024-04-09T17:45:29Z |
| format | Article |
| id | doaj.art-e22eabc4d9654a85a22e25c6d9271611 |
| institution | Directory Open Access Journal |
| issn | 1869-5760 |
| language | English |
| last_indexed | 2024-04-09T17:45:29Z |
| publishDate | 2023-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of Ophthalmic Inflammation and Infection |
| spelling | doaj.art-e22eabc4d9654a85a22e25c6d92716112023-04-16T11:22:11ZengSpringerOpenJournal of Ophthalmic Inflammation and Infection1869-57602023-04-011311810.1186/s12348-023-00339-0Ocular side effects of Trametinib and Dabrafenib: a case reportBilge Tarım0Meltem Kılıç1Department of Ophthalmology, University of Health Sciences, Ankara Bilkent City HospitalDepartment of Ophthalmology, University of Health Sciences, Ankara Bilkent City HospitalAbstract A 53-year-old man who has stage 4 non-small cell lung carcinoma and treated with Dabrafenib-Trametinib combination chemotherapy; presented with decreased bilateral visual acuity. We checked out slit lamp examination, fundoscopy, optical coherence tomography and fundus fluorescein angiography. In slit lamp biomicroscopy; bilateral posterior synechiae, granulomatous keratic precipitates and + 4 cells in the anterior chamber were detected. Cystoid macular edema and subretinal fluid accumulation were revealed in optical coherence tomography. Dabrafenib and Trametinib treatments were discontinued and systemic methylprednisolone, topical corticosteroid and topical cyclopentolate were started. His best corrected visual acuity was increased from counting fingers from 2 m to 0,9 bilaterally and cystoid macular edema and serous retinal detachment were completely regressed as a result of systemic and topical corticosteroid treatment.https://doi.org/10.1186/s12348-023-00339-0TrametinibDabrafenibUveitisCystoid macular edemaSerous retinal detachment |
| spellingShingle | Bilge Tarım Meltem Kılıç Ocular side effects of Trametinib and Dabrafenib: a case report Journal of Ophthalmic Inflammation and Infection Trametinib Dabrafenib Uveitis Cystoid macular edema Serous retinal detachment |
| title | Ocular side effects of Trametinib and Dabrafenib: a case report |
| title_full | Ocular side effects of Trametinib and Dabrafenib: a case report |
| title_fullStr | Ocular side effects of Trametinib and Dabrafenib: a case report |
| title_full_unstemmed | Ocular side effects of Trametinib and Dabrafenib: a case report |
| title_short | Ocular side effects of Trametinib and Dabrafenib: a case report |
| title_sort | ocular side effects of trametinib and dabrafenib a case report |
| topic | Trametinib Dabrafenib Uveitis Cystoid macular edema Serous retinal detachment |
| url | https://doi.org/10.1186/s12348-023-00339-0 |
| work_keys_str_mv | AT bilgetarım ocularsideeffectsoftrametinibanddabrafenibacasereport AT meltemkılıc ocularsideeffectsoftrametinibanddabrafenibacasereport |